Abstract:
PURPOSE OF REVIEW:To describe ion and water homeostatic mechanisms in the inner ear, how they are compromised in hearing disorders, and what treatments are employed to restore auditory function. RECENT FINDINGS:The ion and water transport functions in the inner ear help maintain the proper endolymph K concentration required for hair cell function. Gene defects and idiopathic alterations in these transport functions cause hearing loss, but often the underlying cause is unknown. Current therapies largely involve glucocorticoid treatment, although the mechanisms of restoration are often undeterminable. Recent studies of these ion homeostatic functions in the ear are characterizing their cellular and molecular control. It is anticipated that future management of these hearing disorders will be more targeted to the cellular processes involved and improve the likelihood of hearing recovery. SUMMARY:A better understanding of the ion homeostatic processes in the ear will permit more effective management of their associated hearing disorders. Sufficient insight into many homeostatic hearing disorders has now been attained to usher in a new era of better therapies and improved clinical outcomes.
journal_name
Curr Opin Otolaryngol Head Neck Surgauthors
Trune DRdoi
10.1097/MOO.0b013e32833d9597subject
Has Abstractpub_date
2010-10-01 00:00:00pages
413-9issue
5eissn
1068-9508issn
1531-6998journal_volume
18pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Merkel cell carcinoma (MCC) is a rare, aggressive malignancy. Worldwide incidence is increasing and roughly 50% of patients present with a primary lesion in the head and neck. This article discusses recent advances and treatment recommendations. RECENT FINDINGS:Recent research has focused on the carc...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000029
更新日期:2014-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The management of nasoethmoid or naso-orbito-ethmoid (NOE) fractures requires a thorough knowledge of the central facial anatomy, surgical techniques, available tools and patient factors to obtain optimal restoration of aesthetic form and function. This review article describes the current methods of ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3283631936
更新日期:2013-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Medical error is a common problem, and its human cost in terms of disability, suffering, and death is stunning. Steps toward reducing medical error will require the identification of mistake-prone practices within a complex health care system. Erroneous pathologic diagnosis has been identified as one ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000156162.20789.66
更新日期:2005-04-01 00:00:00
abstract:PURPOSE OF REVIEW:There is an increasing percentage of children with persistent obstructive sleep apnea (OSA) after removal of the tonsils and adenoids (T&A). Although sleep apnea has been an active area of research and treatment in the adult population, our awareness of this problem in children is still in its initial...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32834c1728
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Airway obstruction and craniofacial deformities resulting from mandibular deficiency are challenging and complex clinical problems. Mandibular distraction osteogenesis is playing a rapidly expanding role in the treatment of these children and has supplanted traditional management techniques in many ce...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000143979.33496.0a
更新日期:2004-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Inverted papilloma are benign sinonasal tumors that have a propensity to recur after surgical resection and may undergo malignant transformation. For this reason, complete resection is essential for the successful management of these tumors. Advances in endoscopic techniques and experience, as well as...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32831b9cd1
更新日期:2009-02-01 00:00:00
abstract:PURPOSE OF REVIEW:There is a lack of evidence worldwide on return to work (RTW) in head and neck cancer (HNC), possibly because traditionally those suffering with it were typically at retirement age and survival rates were low. However, in the last 30 years, HNC survival rates have increased, resulting in more people l...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/MOO.0000000000000628
更新日期:2020-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Office-based laryngeal laser surgery was created recently and is emerging as a reliable and practical method of treating a number of laryngeal lesions. This style of minimally invasive surgery is becoming increasingly popular in the United States and abroad. RECENT FINDINGS:Fiber-based lasers and dis...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3281574582
更新日期:2007-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the literature on epistaxis, with a focus on the past 12-18 month, and aims to classify the literature available for this very common otolaryngology emergency. RECENT FINDINGS:Epistaxis can be classified into primary or secondary epistaxis based on cause. It can also be classifie...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328341e1e9
更新日期:2011-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The inter-relationship between allergy and nasal diseases has long been known. Failure to address when allergy is a contributing factor diminishes the possibility of a successful surgical intervention. Sublingual immunotherapy is recommended by the World Health Organization to treat allergic rhinitis ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/01.moo.0000193187.23063.ae
更新日期:2006-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The identification of transcriptional activators and repressors of hair cell fates has recently been augmented by the discovery of microRNAs (miRNAs) that can function as post-transcriptional repressors in sensory hair cells. RECENT FINDINGS:miRNAs are approximately 21-nucleotide single-stranded ribo...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/MOO.0b013e32833e0601
更新日期:2010-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the current literature on isolated disease of sphenoid sinus, and to describe the various approaches to the sphenoid sinus. RECENT FINDINGS:Due to its posterior location and subtle presenting symptoms, sphenoid lesions, in the past, have often been missed and were reported as rare occurrenc...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32834251d6
更新日期:2011-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This study is aimed towards clinicians involved in the rapidly developing field of hair restoration. We provide a review of recent literature on this topic. RECENT FINDINGS:Recent studies discussed in this article focus on various aspects of follicular unit transplant surgery, including hairline desi...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32832da13b
更新日期:2009-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The application of robotic surgery to anterior skull base disease has yet to be defined despite the potential for improved tumour resection with less morbidity in this region. Complex anatomy and restricted access have limited the development of robotic anterior skull base surgery. RECENT FINDINGS:A ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/MOO.0000000000000683
更新日期:2021-02-01 00:00:00
abstract:PURPOSE OF REVIEW:In the surgical management of chronic rhinosinusitis, medical therapy is often used to prevent postoperative complications such as adhesions. These complications often require painful debridements in the clinic or revision surgery. Systemic steroids are not without risk and topical steroids are not id...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000012
更新日期:2014-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Swallowing is a vital function and the clearance of the pharynx by deglutition, which removes matter that could be aspirated, and the respiratory phase patterns associated with deglutition are important in protecting the airways and lungs against aspiration. This article reviews swallowing and respira...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/MOO.0000000000000670
更新日期:2020-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This article will examine recent publications on the endoscopic management of juvenile nasopharyngeal angiofibromas. RECENT FINDINGS:The use of an endoscopic approach to resect small juvenile nasopharyngeal angiofibromas is supported by excellent results from a number of operative series published in...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000188859.91607.65
更新日期:2006-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Laryngopharyngeal reflux is a widely recognized disorder. Yet, decades after its initial description, debate persists regarding pathophysiology, diagnosis, and treatment. This review addresses current literature on laryngopharyngeal reflux and identifies areas of controversy and future opportunities f...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32832b2581
更新日期:2009-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Insulin-like growth factor 1 (IGF-1) is a hormone necessary for the development, growth, and maintenance of various organs, and has been used as a therapeutic agent in clinical settings. This review aimed to illustrate its role in the auditory systems and its potential use as a therapeutic in the fiel...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/MOO.0000000000000652
更新日期:2020-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews literature on the facial reanimation technique, from direct facial nerve repair and grafting to neuromuscular-free transplantation. The discussion will focus on the indications of the different approaches based on timing of the facial palsy and on patient's features. RECENT FINDI...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32834fa744
更新日期:2012-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize the recent knowledge on eustachian tube dysfunction and the patulous eustachian tube. RECENT FINDINGS:A clinically useful test for eustachian tube function is still lacking. Narrowing of the isthmus alone was demonstrated to be an insufficient cause of otiti...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000176465.68128.45
更新日期:2005-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the past year's literature regarding recent innovations in surgical instrumentation for craniomaxillofacial surgery. RECENT FINDINGS:Current advances in surgical instrumentation have led to many improvements in the field, allowing greater visualization and precision both before and during p...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328355a906
更新日期:2012-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Fine needle aspiration is a safe diagnostic technique that is widely employed for lesions of the head and neck. Among head and neck sites, the parotid gland stands apart for the number, diversity and peculiarity of pathologic processes to target this structure. This matchless complexity has prompted a...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000193184.38310.0a
更新日期:2006-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Temporomandibular joint (TMJ) reconstruction represents one of the more challenging clinical problems that a head and neck surgeon encounters. Fortunately, the problem is fairly uncommon; however, at the same time, clear clinical guidelines have not been formulated. The goal of this review is to prese...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000282
更新日期:2016-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the role of vitamin D in asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). RECENT FINDINGS:Over the last several years, the role of vitamin D in immunomodulation has been studied and shown to have a significant impact on immune function. A causal relationship exists between vita...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3283465687
更新日期:2011-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Little is published regarding variations of skull-base anatomy and their relevance to the performance of endoscopic sinus surgery. Several catastrophic complications have occurred in patients with low-lying skull-base variation. This review's purpose is to make the reader aware of skull-base variation...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200502000-00006
更新日期:2005-02-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide a comprehensive overview of the predisposing factors that contribute to a risk of excess bleeding for surgical therapy in the head and neck regions, provide a thorough overview of techniques and tools for managing blood loss complications, and provide intervention algorithms to help guide c...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000461
更新日期:2018-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Clival chordomas are rare malignant tumors associated with a poor prognosis. In this article, we review the current literature to identify a variety of strategies that provide guidelines toward the optimal management for this aggressive tumor. RECENT FINDINGS:Molecular disease, particularly, the deve...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000140
更新日期:2015-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Timely recognition of vascular compromise of free flaps is crucial to salvaging failing flaps. This review summarizes the most recent available literature about free flap monitoring over the period of 2008-2009. Novel techniques are discussed. RECENT FINDINGS:Several case series have been published t...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32832cba6a
更新日期:2009-08-01 00:00:00
abstract:PURPOSE OF REVIEW:This article describes the most recent comparative cost evaluations for subcutaneous (SCIT) and sublingual (SLIT) immunotherapy. RECENT FINDINGS:Only one recent article compares the costs of SCIT and SLIT in America. No American publications assess direct and indirect costs together. Few studies outs...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000159
更新日期:2015-06-01 00:00:00