Abstract:
PURPOSE OF REVIEW:Rhinosinusitis is one of the most common medical complaints in the United States, affecting up to 16% of the population. It is associated with over 13 million physician visits per year and an estimated aggregated cost of over $6 billion annually. Patients with chronic rhinosinusitis (CRS) demonstrate worse quality-of-life scores than those suffering from chronic obstructive pulmonary disease, congestive heart failure, back pain, or angina. Despite the large societal impact and economic burden, the pathophysiology of CRS remains largely unsolved. One possible mechanism for the chronic nature of this disease is the involvement of bacterial biofilms, which represent a phenotypic change in bacteria that make them resistant to conventional treatment strategies. We will discuss these changes as well as emerging treatment options. RECENT FINDINGS:New research involving topical antimicrobials, surfactants, loop diuretics, and macrolide antibiotics can be used as adjuvant therapies to treat biofilm-associated CRS. All have shown some promise in laboratory or small patient studies, but all need further evaluation SUMMARY:Bacterial biofilms are highly organized structures composed of communities of bacteria encased within a protective extracellular matrix. If bacterial biofilms are the cause of certain cases of CRS, then the treatment paradigms will have to be changed. Novel nonantimicrobial therapies may have clinical applications to prevent and destabilize biofilms. We believe that ultimately methods to reduce sinonasal inflammation and protect cilia will be the first step in blocking the attachment and aggregation of bacteria that would otherwise start biofilm formation. Once more is known about the role of biofilms in CRS, new therapies will undoubtedly play a greater role and change our treatment paradigms.
journal_name
Curr Opin Otolaryngol Head Neck Surgauthors
Suh JD,Cohen NA,Palmer JNdoi
10.1097/MOO.0b013e328334f670subject
Has Abstractpub_date
2010-02-01 00:00:00pages
27-31issue
1eissn
1068-9508issn
1531-6998journal_volume
18pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The supraclavicular artery island flap is a rotation flap that offers a versatile reconstructive option for head and neck defects. Recent anatomical studies have improved our understanding of the vascular supply of the supraclavicular artery island flap. Furthermore, several published large series des...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328347f811
更新日期:2011-08-01 00:00:00
abstract:PURPOSE OF REVIEW:This article aims to review previous research reports and to summarize current strategies for the optimal duration of voice rest and the effect of phonatory stimulation after phonomicrosurgery. RECENT FINDINGS:Voice rest is commonly recommended after laryngeal surgery to prevent worsening of vocal fo...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000407
更新日期:2017-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Endoscopic sinus surgery techniques and technologies have undergone rapid development over the past two decades. Recently, image guided systems have been implemented in endoscopic sinus surgery, carrying the promise of increased safety during surgery. This review compiles available data regarding the ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3282fdccad
更新日期:2008-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The management of cervical lymph node metastases in nasopharyngeal carcinoma is important for a favourable outcome. The strategy of diagnosis and treatment for the lymph nodes on presentation and those that have recurred after initial therapy are different. This review presents the current concept. R...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3280148a06
更新日期:2007-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to highlight recent work and provide recommendations on the approach for diagnosis and management of chronic cough in a gastroenterology clinic. RECENT FINDINGS:Chronic cough is a burdensome symptom affecting a large number of patients and contributes significant cost to...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3283658eb0
更新日期:2013-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Office-based laryngeal laser surgery was created recently and is emerging as a reliable and practical method of treating a number of laryngeal lesions. This style of minimally invasive surgery is becoming increasingly popular in the United States and abroad. RECENT FINDINGS:Fiber-based lasers and dis...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3281574582
更新日期:2007-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize the recent knowledge on eustachian tube dysfunction and the patulous eustachian tube. RECENT FINDINGS:A clinically useful test for eustachian tube function is still lacking. Narrowing of the isthmus alone was demonstrated to be an insufficient cause of otiti...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000176465.68128.45
更新日期:2005-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Spontaneous nasal cerebrospinal fluid (CSF) leaks represent a distinct clinical entity that presents important diagnostic and therapeutic challenges. Recognition of the proper demographic group and presenting symptoms, as well as the radiologic features of this disease process, are integral to making ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328011bc76
更新日期:2007-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The objective of this article is to assess current newborn hearing screening protocols. We will focus on technologies or modalities used, protocol steps, training of screeners, timing of first screen, and loss to follow-up. A summary of program reports focusing on protocols from Greece, China, South A...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000389
更新日期:2017-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This study is aimed towards clinicians involved in the rapidly developing field of hair restoration. We provide a review of recent literature on this topic. RECENT FINDINGS:Recent studies discussed in this article focus on various aspects of follicular unit transplant surgery, including hairline desi...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32832da13b
更新日期:2009-08-01 00:00:00
abstract::Leukotrienes are inflammatory mediators that are known as the slow-reacting substance of anaphylaxis produced by a number of cell types including mast cells, eosinophils, basophils, macrophages, and monocytes. Synthesis of these mediators results from the cleavage of arachidonic acid in cell membranes, and they exert ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200306000-00010
更新日期:2003-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to summarize and put into historical perspective current advances in research in otosclerosis, a disorder of the human temporal bone with a hereditary predisposition that is among the most common causes of acquired hearing loss. RECENT FINDINGS:Genetic studies have revealed...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000244194.97301.19
更新日期:2006-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Midfacial defects resulting from head and neck oncological resections can be addressed by microvascular reconstructive techniques using autologous tissue. In specific indications, however, prosthetic rehabilitation can give a superior aesthetic outcome, combined with a less intensive surgical strain o...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000241
更新日期:2016-04-01 00:00:00
abstract:PURPOSE OF REVIEW:There is an increasing percentage of children with persistent obstructive sleep apnea (OSA) after removal of the tonsils and adenoids (T&A). Although sleep apnea has been an active area of research and treatment in the adult population, our awareness of this problem in children is still in its initial...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32834c1728
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Bisphosphonates are used for the management of metastatic bone disease, prevention and treatment of osteoporosis and Paget's disease of bone. An increasing number of reports have associated the use of bisphosphonates with the occurrence of osteoradionecrosis of the jaw. The purpose of this review is t...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328304b445
更新日期:2008-08-01 00:00:00
abstract:PURPOSE OF REVIEW:There is currently strong evidence supporting human papilloma virus (HPV) causation in a distinct disease entity of oropharyngeal cancer (OPC), with an increasing incidence worldwide.This review aims to critically analyse whether a change in our management approaches to HPV-positive OPC is now require...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3283509735
更新日期:2012-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Distraction osteogenesis is finding increasing application in the management of mandibular defects. It provides an alternative method of mandibular reconstruction in varied clinical settings, notably following trauma and ablation of malignant tumors. Many recent studies have explored modifications in ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3282495925
更新日期:2007-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the literature on toluidine blue (TBlue) and to discuss the utility of TBlue in assessing and in clinical management of patients with oral mucosal lesions. The literature search was conducted using key word search including oral cancer, oral premalignant lesions, and TBlue and by selecting r...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/moo.0b013e32832771da
更新日期:2009-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses recent progress in research that seeks to understand the regeneration of hair cells and highlights findings that may hold importance for the eventual development of regenerative therapies for hearing and balance impairments. RECENT FINDINGS:Signaling via the Notch receptor and t...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32830f4ab5
更新日期:2008-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the anatomy and function of the midface, defect classifications and the breadth of common and novel reconstructive techniques including medical modeling, dental splints, and dental rehabilitation. RECENT FINDINGS:Historically many classification systems for midface and maxillary ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000396
更新日期:2017-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe and popularize the transmanubrial osteomuscular-sparing approach (TOSA) outside its original thoracic surgical field of application, based on the consideration that it could be of interest for the management of a number of head and neck cases in both elective and emergent scenarios. RECEN...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000605
更新日期:2020-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Little is published regarding variations of skull-base anatomy and their relevance to the performance of endoscopic sinus surgery. Several catastrophic complications have occurred in patients with low-lying skull-base variation. This review's purpose is to make the reader aware of skull-base variation...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200502000-00006
更新日期:2005-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews literature on the scientific background of functional electric stimulation of the immobile larynx, the status of animal pacing trials, and first clinical attempts to establish laryngeal pacing. RECENT FINDINGS:Impaired vocal fold motion is seen following recurrent laryngeal nerve...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32834cb7ba
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Skull base osteomyelitis secondary to malignant otitis externa was first described in 1959. Since then, advances have been made in the diagnosis, treatment, and clinical outcomes of this condition. RECENT FINDINGS:This review discusses the pathophysiology and microbiology of malignant otitis externa....
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200310000-00002
更新日期:2003-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This review is designed to update the reader on the current state of nasal endoscopy in the control of epistaxis. Recent articles are reviewed and demonstrate recent developments and results. RECENT FINDINGS:The use of endoscopy for control of anterior and posterior epistaxis is beneficial, with less...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200402000-00012
更新日期:2004-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Sclerosing bone dysplasias are rare genetic disorders of bone remodeling in which excessive bone formation takes place, resulting in encroachment on neural structures. The infant usually appears normal at birth, and the first sign of a problem only comes when a neurologic deficit develops, usually in ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000134441.84110.9e
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe contemporary interpretations of 'outcomes research' in facial plastic surgery and to summarize and evaluate some of the existing validated outcome measures for use in facial plastic surgery. RECENT FINDINGS:Outcome measures can be broadly categorized into two categories - patient-reported...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3283031ac9
更新日期:2008-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe ion and water homeostatic mechanisms in the inner ear, how they are compromised in hearing disorders, and what treatments are employed to restore auditory function. RECENT FINDINGS:The ion and water transport functions in the inner ear help maintain the proper endolymph K concentration re...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32833d9597
更新日期:2010-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Globus pharyngeus is a common condition of unknown cause, with no 'current opinion' on the optimum investigation and treatment. As such, the scope of this article is to review the current literature and to describe, from an Irish perspective, the current best practice on the management of globus. REC...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/MOO.0b013e3283169258
更新日期:2008-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Thin caliber transnasal esophagoscopes allow for a rapidly expanding array of office-based esophageal procedures, including botulinum toxin injections, in unsedated patients. RECENT FINDINGS:While botulinum toxin has been used in the esophagus and lower esophageal sphincter for many years, there is n...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3282f1bf39
更新日期:2007-12-01 00:00:00