Abstract:
PURPOSE OF REVIEW:This review discusses recent progress in research that seeks to understand the regeneration of hair cells and highlights findings that may hold importance for the eventual development of regenerative therapies for hearing and balance impairments. RECENT FINDINGS:Signaling via the Notch receptor and the basic helix-loop-helix transcription factors has important roles in the development and regeneration of hair cells. The cytoskeletal properties and cell-matrix interactions of supporting cells in mice of different ages may hold part of the explanation for the age-related differences in their proliferative responses to damage and the differences between mammals and nonmammals in hair cell regeneration. Progress also has been made in deriving stem cells from inner ear tissues and other sources and in the evaluation of their potential uses as sources of new hair cells and as tools for biomedical research. SUMMARY:Much has been accomplished since the discovery of postembryonic hair cell production and hair cell regeneration in nonmammals decades ago. No therapies for hair cell regeneration are under clinical trials, but research is yielding potentially important discoveries that are likely to lead to the development of therapeutic methods for inducing hair cell regeneration in the mammalian inner ear.
journal_name
Curr Opin Otolaryngol Head Neck Surgauthors
Collado MS,Burns JC,Hu Z,Corwin JTdoi
10.1097/MOO.0b013e32830f4ab5subject
Has Abstractpub_date
2008-10-01 00:00:00pages
465-71issue
5eissn
1068-9508issn
1531-6998pii
00020840-200810000-00013journal_volume
16pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Overall survival of head and neck squamous cell carcinoma patients on the whole has not dramatically improved in the last 30 years. One of the reasons is that tumour, node, metastasis classification is probably in some cases inadequate, since similar cases under a clinico-pathological point of view, m...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3282f6a4b0
更新日期:2008-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews literature on the scientific background of functional electric stimulation of the immobile larynx, the status of animal pacing trials, and first clinical attempts to establish laryngeal pacing. RECENT FINDINGS:Impaired vocal fold motion is seen following recurrent laryngeal nerve...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32834cb7ba
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Insulin-like growth factor 1 (IGF-1) is a hormone necessary for the development, growth, and maintenance of various organs, and has been used as a therapeutic agent in clinical settings. This review aimed to illustrate its role in the auditory systems and its potential use as a therapeutic in the fiel...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/MOO.0000000000000652
更新日期:2020-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Temporomandibular joint (TMJ) reconstruction represents one of the more challenging clinical problems that a head and neck surgeon encounters. Fortunately, the problem is fairly uncommon; however, at the same time, clear clinical guidelines have not been formulated. The goal of this review is to prese...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000282
更新日期:2016-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Globus pharyngeus is a common condition of unknown cause, with no 'current opinion' on the optimum investigation and treatment. As such, the scope of this article is to review the current literature and to describe, from an Irish perspective, the current best practice on the management of globus. REC...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/MOO.0b013e3283169258
更新日期:2008-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Bone anchored hearing aids are an acceptable and now widely available form of aural rehabilitation for both adults and children. Their benefit from both audiological and quality of life perspectives has been very successful to date. The paediatric population presents a variety of challenges to those c...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32833237d7
更新日期:2009-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Bisphosphonates are used for the management of metastatic bone disease, prevention and treatment of osteoporosis and Paget's disease of bone. An increasing number of reports have associated the use of bisphosphonates with the occurrence of osteoradionecrosis of the jaw. The purpose of this review is t...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328304b445
更新日期:2008-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The identification of transcriptional activators and repressors of hair cell fates has recently been augmented by the discovery of microRNAs (miRNAs) that can function as post-transcriptional repressors in sensory hair cells. RECENT FINDINGS:miRNAs are approximately 21-nucleotide single-stranded ribo...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
doi:10.1097/MOO.0b013e32833e0601
更新日期:2010-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Clival chordomas are rare malignant tumors associated with a poor prognosis. In this article, we review the current literature to identify a variety of strategies that provide guidelines toward the optimal management for this aggressive tumor. RECENT FINDINGS:Molecular disease, particularly, the deve...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000140
更新日期:2015-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This article will examine recent publications on the endoscopic management of juvenile nasopharyngeal angiofibromas. RECENT FINDINGS:The use of an endoscopic approach to resect small juvenile nasopharyngeal angiofibromas is supported by excellent results from a number of operative series published in...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000188859.91607.65
更新日期:2006-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Rhinosinusitis is one of the most common medical complaints in the United States, affecting up to 16% of the population. It is associated with over 13 million physician visits per year and an estimated aggregated cost of over $6 billion annually. Patients with chronic rhinosinusitis (CRS) demonstrate ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328334f670
更新日期:2010-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to highlight recent literature related to the initial management and reconstruction of blast injuries to the head and neck. RECENT FINDINGS:An increasing percentage of combat-related injuries are caused by blast trauma. Management of blast trauma over the last 10 years h...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000285
更新日期:2016-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Patients being treated for chronic rhinosinusitis, whether via medical or surgical means, account for a significant percentage of all medical malpractice claims against otolaryngologists. In this study, we present suggestions to help otolaryngologists safeguard against unnecessary claims. RECENT FIND...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000024
更新日期:2014-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Merkel cell carcinoma (MCC) is a rare, aggressive malignancy. Worldwide incidence is increasing and roughly 50% of patients present with a primary lesion in the head and neck. This article discusses recent advances and treatment recommendations. RECENT FINDINGS:Recent research has focused on the carc...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000029
更新日期:2014-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Functional rhinoplasty is a term that is commonly used to describe any technique used to address nasal obstruction in the nasal valve region. The cause of nasal valve collapse differs based on the site. Internal valve collapse may be idiopathic or associated with previous rhinoplasty, trauma, or weake...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000172
更新日期:2015-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to go over the only therapy for olfactory loss supported by level 1a evidence that is currently available, which is olfactory training. This therapy is widely underutilized and has the potential to help many patients with olfactory dysfunction who are otherwise offered no...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000328
更新日期:2017-02-01 00:00:00
abstract:PURPOSE OF REVIEW:In the surgical management of chronic rhinosinusitis, medical therapy is often used to prevent postoperative complications such as adhesions. These complications often require painful debridements in the clinic or revision surgery. Systemic steroids are not without risk and topical steroids are not id...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000012
更新日期:2014-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The management of a patient with bilateral vocal fold motion impairment (BVFMI) can be challenging for the otolaryngologist. The treatment traditionally involves tracheotomy, which can be very distressful for some patients. Alternatively, there are endoscopic procedures, which irreversibly sacrifice v...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32834c1e4f
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Free flap surgery has revolutionized our ability to perform composite reconstructions following ablative surgery. Although flap failure is rare (∼5%), it results in high patient morbidity if not recognized and corrected early. There are numerous means to assess flap viability. We review the recent lit...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000189
更新日期:2015-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The anterolateral thigh free flap has achieved recent popularity in North America for the reconstruction of head and neck defects after ablative surgery. The flap is most often based on either the septocutaneous or musculocutaneous perforators of the descending branch of the lateral circumflex femoral...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000130575.10656.97
更新日期:2004-08-01 00:00:00
abstract:PURPOSE:The purpose of this review is to provide the reader with current information regarding the standards for audiologic assessment of infants and very young children. The nature of the appropriate test battery and the need for adjusting test procedures to meet the specific needs of infants and toddlers are emphasiz...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200310000-00012
更新日期:2003-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Laryngopharyngeal reflux should no longer be underestimated because of its negative impact on the lives of patients and its potentially dangerous long-term complications. RECENT FINDINGS:Both laryngopharyngeal reflux and gastroesophageal reflux disease are caused by mucosal injury from acid and pepsi...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000193189.17225.91
更新日期:2006-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The increasing magnet strengths used for MRI scanning combined with a greater number and variety of otologic prostheses can lead to possible safety issues. This review examines the specific issues and the conclusions of 33 referenced studies examining those issues. RECENT FINDINGS:Variability of inte...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328270b8b4
更新日期:2007-10-01 00:00:00
abstract::The presence of cervical lymph node metastasis remains the most significant prognostic indicator of survival and disease recurrence in patients with squamous cell carcinoma of the head and neck. An approximately 50% reduction in 5-year survival rate is seen with the development of lymph node metastasis in patients wit...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200304000-00010
更新日期:2003-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to highlight recent work and provide recommendations on the approach for diagnosis and management of chronic cough in a gastroenterology clinic. RECENT FINDINGS:Chronic cough is a burdensome symptom affecting a large number of patients and contributes significant cost to...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3283658eb0
更新日期:2013-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The management of benign vocal fold lesions (BVFLs) continues to evolve. This article will review the recent literature surrounding the nomenclature, cause, diagnosis, and treatment of BVFLs, including polyps, nodules, cysts, and reactive lesions. RECENT FINDINGS:The taxonomy of vocal fold lesions ha...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000408
更新日期:2017-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the anatomy and function of the midface, defect classifications and the breadth of common and novel reconstructive techniques including medical modeling, dental splints, and dental rehabilitation. RECENT FINDINGS:Historically many classification systems for midface and maxillary ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000396
更新日期:2017-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This article considers current evidence pertaining to good practice in joint paediatric speech and language therapy (SLT) and ear, nose and throat (ENT) assessment and management in the general hospital clinic. Because of space limitations, this review excludes those cases that are typically referred ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000057
更新日期:2014-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This article aims to review previous research reports and to summarize current strategies for the optimal duration of voice rest and the effect of phonatory stimulation after phonomicrosurgery. RECENT FINDINGS:Voice rest is commonly recommended after laryngeal surgery to prevent worsening of vocal fo...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000407
更新日期:2017-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Surgical approaches to the upper facial skeleton comprise the coronal, lower eyelid and midface degloving approaches. These are routinely employed in both ablative and reconstructive craniofacial procedures. The ability to perform them in a well tolerated and predictable manner is predicated on knowle...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328347f895
更新日期:2011-08-01 00:00:00