Abstract:
PURPOSE OF REVIEW:The aim of this article is to summarize and put into historical perspective current advances in research in otosclerosis, a disorder of the human temporal bone with a hereditary predisposition that is among the most common causes of acquired hearing loss. RECENT FINDINGS:Genetic studies have revealed that otosclerosis is heterogeneous, with evidence for defects in at least seven genes associated with six distinct chromosomal loci. Measurements of high levels of osteoprotegerin expression in the normal otic capsule and soft tissues of the cochlea provide the first molecular insight as to why the normal otic capsule remodels minimally, if at all. Osteoprotegerin knockout mice provide the best available animal model to date to study abnormal otic capsule remodeling that closely resembles otosclerosis. There is mounting evidence that the measles virus plays an important role in pathogenesis of otosclerosis although the mechanisms by which the virus results in otosclerosis remain unknown. Quantitative measures of angiogenesis can reliably distinguish between clinical and histological otosclerosis. Advances in the emerging field of osteoimmunology will likely impact and benefit from the research in otosclerosis. SUMMARY:Insights into molecular mechanisms that inhibit extensive remodeling in the normal otic capsule, and understanding of how these mechanisms are dysregulated in otosclerosis will allow future design of rational treatment strategies for otosclerosis.
journal_name
Curr Opin Otolaryngol Head Neck Surgauthors
Stankovic KM,McKenna MJdoi
10.1097/01.moo.0000244194.97301.19subject
Has Abstractpub_date
2006-10-01 00:00:00pages
347-51issue
5eissn
1068-9508issn
1531-6998pii
00020840-200610000-00012journal_volume
14pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The purpose of this review is to go over the only therapy for olfactory loss supported by level 1a evidence that is currently available, which is olfactory training. This therapy is widely underutilized and has the potential to help many patients with olfactory dysfunction who are otherwise offered no...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000328
更新日期:2017-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the literature on epistaxis, with a focus on the past 12-18 month, and aims to classify the literature available for this very common otolaryngology emergency. RECENT FINDINGS:Epistaxis can be classified into primary or secondary epistaxis based on cause. It can also be classifie...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328341e1e9
更新日期:2011-02-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the recent literature describing the association between chronic rhinosinusitis and its effects on sleep quality. RECENT FINDINGS:Chronic rhinosinusitis (CRS) causes significantly worse sleep by both subjective and objective measures. CRS is also strongly associated with obstructive sleep a...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000600
更新日期:2020-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Recurrent respiratory papillomatosis (RRP) is the most common as well as the costliest benign airway neoplasm in the United States [Ivancic et al. (2018). Laryngoscope Investig Otolaryngol 3:22; Derkay (1995). Arch Otolaryngol Head Neck Surg 121:1386]. In addition, it is potentially deadly, with risk ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000490
更新日期:2018-12-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000067
更新日期:2014-08-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32832cee83
更新日期:2009-08-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200404000-00013
更新日期:2004-04-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000024
更新日期:2014-02-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328011bc76
更新日期:2007-02-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3283658eb0
更新日期:2013-12-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/moo.0b013e328325a538
更新日期:2009-04-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3282f1c7d0
更新日期:2008-02-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000247
更新日期:2016-06-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000130575.10656.97
更新日期:2004-08-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000326
更新日期:2017-02-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000237
更新日期:2016-04-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200310000-00012
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2005-02-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2020-04-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2016-04-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2011-02-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
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更新日期:2020-10-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2006-08-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
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更新日期:2009-10-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00