Adenoid cystic carcinoma of the head and neck: a review.

Abstract:

PURPOSE OF REVIEW:This purpose of this article is to review and provide an update of current publications on the evaluation and management of adenoid cystic carcinoma. RECENT FINDINGS:Adenoid cystic carcinoma is an uncommon salivary gland malignancy that presents insidiously and is generally advanced when diagnosed. Current effective treatment modalities include surgery and irradiation, but locoregional recurrences are frequent and may present as early as 2 years. Patients survive with recurrent and metastatic disease for several years despite not being offered any treatment. Molecular analysis of the tumors is being undertaken, with optimistic results capable of selecting high-risk patients who may benefit from adjuvant treatment such as chemotherapy SUMMARY:Little progress has been made in advancing "curative" treatment of adenoid cystic carcinoma of the head and neck. The disease is said to have a fatal outcome. The time is now opportune for a multicenter, randomized, controlled trial to identify patients who would benefit from adjuvant radiotherapy and/or chemotherapy in the control of locoregional recurrences and the prevention of distant metastases.

authors

Bradley PJ

doi

10.1097/00020840-200404000-00013

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

127-32

issue

2

eissn

1068-9508

issn

1531-6998

pii

00020840-200404000-00013

journal_volume

12

pub_type

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