Abstract:
:Leukotrienes are inflammatory mediators that are known as the slow-reacting substance of anaphylaxis produced by a number of cell types including mast cells, eosinophils, basophils, macrophages, and monocytes. Synthesis of these mediators results from the cleavage of arachidonic acid in cell membranes, and they exert their biologic effects by binding and activating specific adaptors. This occurs in a series of events that lead to contraction of the human airway smooth muscle, chemotaxis, and increased vascular permeability. These effects have led to their important role in the diseases of asthma, allergic rhinitis, and possible paranasal sinusitis with the formation of nasal polyps. Because these agents lead to the production of symptoms in patients that are asthmatic, the use of leukotriene enzyme inhibitors, particularly montelukast, and zafirlukasts seem appropriate. These classes of drugs can block the binding of leukotrienes to CysLT(1) receptors. Zileuton is a 5-lipoxygenase inhibitor that prevents the formation of leukotrienes and can also result in the prevention of leukotriene activity. Demonstrated efficacy in these patients in a number of studies has also suggested their role in inhibiting nasal symptoms in asthmatic patients. In addition, it has been suggested by serendipitous observations that many of the aspirin-intolerant patients have nasal polyps and that treatment with the leukotriene inhibitors has resulted in improvement and resolution of the polyps. Therefore, these agents may also play a role in patients afflicted with chronic sinusitis with concomitant nasal polyposis. These papers are discussed in detail because this form of therapy may represent a novel way to treat patients with this malady in addition to or in lieu of surgical treatment and steroid therapy.
journal_name
Curr Opin Otolaryngol Head Neck Surgauthors
Parnes SMdoi
10.1097/00020840-200306000-00010keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
184-91issue
3eissn
1068-9508issn
1531-6998journal_volume
11pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To review treatment options for sinonasal polyps, focusing on the role of steroids and, specifically, intrapolyp steroid injection. History of steroid injections, comparison to other medical and surgical treatments, as well as the risks and safety of injections are all discussed. RECENT FINDINGS:A pa...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3282f1c7d0
更新日期:2008-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Adult laryngotracheal stenosis (LTS) is a potentially life-threatening disorder that can be difficult to diagnose and treat. Much is unknown regarding the etiology of airway stenosis, and while many patients do well with standard surgical management, the recurrence rate is significant. Few medical the...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000305
更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe ion and water homeostatic mechanisms in the inner ear, how they are compromised in hearing disorders, and what treatments are employed to restore auditory function. RECENT FINDINGS:The ion and water transport functions in the inner ear help maintain the proper endolymph K concentration re...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32833d9597
更新日期:2010-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The current article reviews the literature on the distribution of nasal irrigation in the treatment of chronic sinusitis, especially in how sinus surgery and irrigation techniques affect its delivery to the nasal cavity and paranasal sinuses. RECENT FINDINGS:Nasal irrigation has become a useful tool ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000429
更新日期:2018-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the literature on patient adherence to two different approaches to allergen-specific immunotherapy for allergic disease. Factors related to adherence in general, as well as the various methods used to measure adherence, will be discussed. RECENT FINDINGS:Although a complex intera...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32835f8048
更新日期:2013-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This article will examine recent publications on the endoscopic management of juvenile nasopharyngeal angiofibromas. RECENT FINDINGS:The use of an endoscopic approach to resect small juvenile nasopharyngeal angiofibromas is supported by excellent results from a number of operative series published in...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000188859.91607.65
更新日期:2006-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Free flap surgery has revolutionized our ability to perform composite reconstructions following ablative surgery. Although flap failure is rare (∼5%), it results in high patient morbidity if not recognized and corrected early. There are numerous means to assess flap viability. We review the recent lit...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000189
更新日期:2015-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the current indications for ventilation tube placement RECENT FINDINGS:In the past year, several studies have challenged the current guidelines for ventilation tube placement and antibiotic use for otitis media in children. Critics argue that some of these studies have poor scientific vali...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3283095046
更新日期:2008-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The anterolateral thigh free flap has achieved recent popularity in North America for the reconstruction of head and neck defects after ablative surgery. The flap is most often based on either the septocutaneous or musculocutaneous perforators of the descending branch of the lateral circumflex femoral...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000130575.10656.97
更新日期:2004-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Distraction osteogenesis is finding increasing application in the management of mandibular defects. It provides an alternative method of mandibular reconstruction in varied clinical settings, notably following trauma and ablation of malignant tumors. Many recent studies have explored modifications in ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3282495925
更新日期:2007-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Facial paralysis often has a significant emotional impact on patients. Along with the myriad of new surgical techniques in managing facial paralysis comes the challenge of selecting the most effective procedure for the patient. This review delineates common surgical techniques and reviews state-of-the...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000233594.84175.a0
更新日期:2006-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe contemporary interpretations of 'outcomes research' in facial plastic surgery and to summarize and evaluate some of the existing validated outcome measures for use in facial plastic surgery. RECENT FINDINGS:Outcome measures can be broadly categorized into two categories - patient-reported...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3283031ac9
更新日期:2008-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Hair cells and spiral ganglion neurons form functional pairings in the cochlea that transduce the mechanical energy of sound into signals that are carried to the brainstem. Mutations of genes affecting the development and maintenance of these two cell populations cause deafness in humans and other ani...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000134451.07239.66
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses recent progress in research that seeks to understand the regeneration of hair cells and highlights findings that may hold importance for the eventual development of regenerative therapies for hearing and balance impairments. RECENT FINDINGS:Signaling via the Notch receptor and t...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32830f4ab5
更新日期:2008-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews literature pertaining to advances in the reconstruction of segmental mandibular defects in the context of an established standard of care, microvascular transfer of free osteocutaneous flaps. RECENT FINDINGS:Most literature reiterates established reconstructive techniques. Except...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328355d0f3
更新日期:2012-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Orbital floor blowout fractures may lead to significant morbidity, including debilitating double vision and globe malposition. Thorough evaluation and timely surgical intervention may prevent long-term sequelae. RECENT FINDINGS:New studies have demonstrated certain patients with orbital floor fractur...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000550
更新日期:2019-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Fine needle aspiration is a safe diagnostic technique that is widely employed for lesions of the head and neck. Among head and neck sites, the parotid gland stands apart for the number, diversity and peculiarity of pathologic processes to target this structure. This matchless complexity has prompted a...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000193184.38310.0a
更新日期:2006-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Bisphosphonates are used for the management of metastatic bone disease, prevention and treatment of osteoporosis and Paget's disease of bone. An increasing number of reports have associated the use of bisphosphonates with the occurrence of osteoradionecrosis of the jaw. The purpose of this review is t...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328304b445
更新日期:2008-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Rhinosinusitis is one of the most common medical complaints in the United States, affecting up to 16% of the population. It is associated with over 13 million physician visits per year and an estimated aggregated cost of over $6 billion annually. Patients with chronic rhinosinusitis (CRS) demonstrate ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328334f670
更新日期:2010-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Swallowing disorders impact the health and quality of millions of lives of patients across the age spectrum. The broad scope of the problem is in contrast to the volume of methods that we have to treat the problem. Investigators are testing interventions that go beyond the swallowing system and are ta...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3282febd4b
更新日期:2008-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Thin caliber transnasal esophagoscopes allow for a rapidly expanding array of office-based esophageal procedures, including botulinum toxin injections, in unsedated patients. RECENT FINDINGS:While botulinum toxin has been used in the esophagus and lower esophageal sphincter for many years, there is n...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e3282f1bf39
更新日期:2007-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Midfacial defects resulting from head and neck oncological resections can be addressed by microvascular reconstructive techniques using autologous tissue. In specific indications, however, prosthetic rehabilitation can give a superior aesthetic outcome, combined with a less intensive surgical strain o...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000241
更新日期:2016-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the incidence, risk factors, prevention, and management of hypothyroidism among patients treated with radiation and other modalities for head and neck cancers. RECENT FINDINGS:Hypothyroidism may occur in up to 48% of patients treated for head and neck malignancies. It has been observed af...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/moo.0b013e328325a538
更新日期:2009-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews literature on the facial reanimation technique, from direct facial nerve repair and grafting to neuromuscular-free transplantation. The discussion will focus on the indications of the different approaches based on timing of the facial palsy and on patient's features. RECENT FINDI...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32834fa744
更新日期:2012-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Inverted papilloma are benign sinonasal tumors that have a propensity to recur after surgical resection and may undergo malignant transformation. For this reason, complete resection is essential for the successful management of these tumors. Advances in endoscopic techniques and experience, as well as...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32831b9cd1
更新日期:2009-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Sclerosing bone dysplasias are rare genetic disorders of bone remodeling in which excessive bone formation takes place, resulting in encroachment on neural structures. The infant usually appears normal at birth, and the first sign of a problem only comes when a neurologic deficit develops, usually in ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/01.moo.0000134441.84110.9e
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This purpose of this article is to review and provide an update of current publications on the evaluation and management of adenoid cystic carcinoma. RECENT FINDINGS:Adenoid cystic carcinoma is an uncommon salivary gland malignancy that presents insidiously and is generally advanced when diagnosed. C...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/00020840-200404000-00013
更新日期:2004-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review briefly explains the basic facts about nitric oxide, which is entering clinical practice as a measure of lower airways inflammation and is likely also to be employed in otorhinolaryngological practice. RECENT FINDINGS:These include the validity of nasal nitric oxide in diagnosing primary ...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e32825b0763
更新日期:2007-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The supraclavicular artery island flap is a rotation flap that offers a versatile reconstructive option for head and neck defects. Recent anatomical studies have improved our understanding of the vascular supply of the supraclavicular artery island flap. Furthermore, several published large series des...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0b013e328347f811
更新日期:2011-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Patients being treated for chronic rhinosinusitis, whether via medical or surgical means, account for a significant percentage of all medical malpractice claims against otolaryngologists. In this study, we present suggestions to help otolaryngologists safeguard against unnecessary claims. RECENT FIND...
journal_title:Current opinion in otolaryngology & head and neck surgery
pub_type: 杂志文章,评审
doi:10.1097/MOO.0000000000000024
更新日期:2014-02-01 00:00:00