当前位置： SCI文献检索 > INTERNATIONAL ENDODONTIC JOURNAL期刊下所有文献 > Expression of MMP-8 and MMP-13 in the development of periradicular lesions.

Expression of MMP-8 and MMP-13 in the development of periradicular lesions.

Abstract：

AIM:To elucidate the expressions of MMP-8 and MMP-13 in experimentally induced rat periradicular lesions by means of the reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical staining. METHODOLOGY:Thirty rats were used and periradicular lesions in mandibular first molar teeth were established following pulp exposure. The animals were sacrificed at 0 (no exposure control), 1, 2, 3, 4 and 6 weeks after pulp exposure. The right molars were used for RT-PCR analysis of MMP-8 and MMP-13. The left molars were subjected to immunohistochemical staining with both MMPs. The areas of these lesions were measured histometrically, and the numbers of both reactive cells in the periapical portion were counted per unit area. Significant differences were analysed by the Mann-Whitney U-test. RESULTS:MMP-8 gene expression gradually increased from 2 to 4 weeks, but slightly decreased at 6 weeks. MMP-13 gene expression gradually increased from 1 to 3 weeks. At 4 and 6 weeks, the level of expression was as high as that at 3 weeks. Immunohistochemically, MMP-8 was first detected at 2 weeks and gradually increased until 4 weeks. MMP-13 gradually increased from 1 to 4 weeks. Both MMPs decreased at 6 weeks. The area of the periradicular lesions gradually increased from 1 to 4 weeks, showing a large increase in week 2 and 3 in particular, but then decreased in week 6. MMP-13-expressing cells were significantly greater than MMP-8-positive cells at week 1 and 2. CONCLUSIONS:These findings indicate that MMP-8 and MMP-13 were related to the development of periradicular lesions. It is suggested that MMP-13 increased from an early stage during their development and that MMP-8 is involved in the progression of tissue destruction including bone resorption.

journal_name

Int Endod J

journal_title

International endodontic journal

authors

Matsui H,Yamasaki M,Nakata K,Amano K,Nakamura H

doi

10.1111/j.1365-2591.2011.01880.x

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

739-45

issue

8

eissn

0143-2885

issn

1365-2591

journal_volume

44

pub_type

杂志文章

相关文献

INTERNATIONAL ENDODONTIC JOURNAL文献大全
  • A systematic review of in vivo retrograde obturation materials.

    abstract：PURPOSE:The aim of this study was to answer the question: For patients requiring apicoectomy (apicectomy/root-end resection) and retrograde (root-end) obturation (filling), which retrograde obturation (root-end filling) material(s) is/are the most effective, as determined by reduction in periapical radiolucency and eli...

    journal_title：International endodontic journal

    pub_type： 杂志文章,meta分析,评审

    doi：10.1046/j.1365-2591.2003.00696.x

    authors： Niederman R,Theodosopoulou JN

    更新日期：2003-09-01 00:00:00

  • A simple mounting model for consistent determination of the accuracy and repeatability of apex locators.

    abstract：AIM:To develop a precise and simple mounting model (MM) for evaluating apex locators and to compare the repeatability of the MM with a conventional visual method (VM). METHODOLOGY:Electronic working length determination was performed in 32 maxillary central incisors using two methods: (i) the MM method and (ii) a conv...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2006.01052.x

    authors： ElAyouti A,Löst C

    更新日期：2006-02-01 00:00:00

  • Evaluation of the radiopacity of calcium silicate cements containing different radiopacifiers.

    abstract：AIM:To identify the suitable ratio of alternative radiopacifiers to impart the necessary radiopacity to calcium silicate cements (CSC) and assess the purity of the radiopacifying agents. METHODOLOGY:Alternative radiopacifying materials for incorporation into CSC included barium sulphate, titanium oxide, zinc oxide, go...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2009.01621.x

    authors： Camilleri J,Gandolfi MG

    更新日期：2010-01-01 00:00:00

  • Morphometric analysis of shank-to-flute ratio in rotary nickel-titanium files.

    abstract：AIM:To evaluate the shank-to-flute ratio in rotary nickel-titanium (Ni-Ti) instruments. METHODOLOGY:The cutting portion of 15 size 30 Ni-Ti rotary instruments, ProFile.04, ProFile.06, Pow R.02, Pow R.04 and Quantec series 2000, were examined. The handles of the instruments were fixed to a bench and supported by a remo...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2004.00755.x

    authors： Biz MT,Figueiredo JA

    更新日期：2004-06-01 00:00:00

  • Reparative bone-like tissue formation in the tooth of a systemic sclerosis patient.

    abstract：AIM:To report a case of reparative bone-like tissue formation in the tooth of a patient with systemic sclerosis. SUMMARY:A 58-year-old Japanese female patient with systemic sclerosis was referred because of tooth fracture. Cone beam computerized tomography (CBCT) revealed multiple root resorption and the unclear trans...

    journal_title：International endodontic journal

    pub_type：

    doi：10.1111/iej.12914

    authors： Matsuda S,Memida T,Mizuno N,Ogawa I,Ouhara K,Kajiya M,Fujita T,Sugiyama E,Kurihara H

    更新日期：2018-09-01 00:00:00

  • Root canal treatment of a root-fractured incisor tooth with internal resorption: a case report.

    abstract：:A case is described in which root canal treatment with calcium hydroxide was used successfully to repair a fracture site with internal resorption of the tooth. ...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.1996.tb01404.x

    authors： Calişkan MK,Türkün M

    更新日期：1996-11-01 00:00:00

  • Resolution of persistent periapical infection by endodontic surgery.

    abstract：AIM:To examine the surfaces of a root tip removed during surgical endodontic treatment for the presence of microorganisms. SUMMARY:The present clinical case illustrates an endodontic retreatment of a maxillary premolar tooth with a fistula and periapical reaction. The case was under treatment for 1 year, during which ...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2004.00753.x

    authors： Ferreira FB,Ferreira AL,Gomes BP,Souza-Filho FJ

    更新日期：2004-01-01 00:00:00

  • Relationship between unintentional canal overfilling and the long-term outcome of primary root canal treatments and nonsurgical retreatments: a retrospective radiographic assessment.

    abstract：AIM:To determine retrospectively the long-term radiographic outcome of root canal treatments and root canal retreatments with unintentional root canal overfilling. METHODOLOGY:A total of 220 root canal treatments (143 primary/77 retreatments) with postoperative unintentional canal overfilling and performed by two endo...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.13209

    authors： Goldberg F,Cantarini C,Alfie D,Macchi RL,Arias A

    更新日期：2020-01-01 00:00:00

  • Morphometric study of the apical anatomy of C-shaped root canal systems in mandibular second molars.

    abstract：AIM:To investigate the apical anatomy of C-shaped canal systems in mandibular second molars by micro-computerized tomography (microCT) and stereomicroscopy. METHODOLOGY:Forty-four permanent mandibular second molars with a C-shaped root canal systems from a native Chinese population were scanned at 100 microm intervals...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2007.01193.x

    authors： Cheung GS,Yang J,Fan B

    更新日期：2007-04-01 00:00:00

  • The effects of Ledermix paste on discolouration of immature teeth.

    abstract：AIM:The aims of this study were to: (i) investigate the effects of Ledermix paste as an intracanal medicament on discolouration of immature teeth, (ii) examine whether the discolouring effects were related to the method of application, (iii) examine the effects of sunlight upon discolouration of immature teeth and (iv)...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1046/j.1365-2591.2000.00277.x

    authors： Kim ST,Abbott PV,McGinley P

    更新日期：2000-05-01 00:00:00

  • Investigation of the root canal configuration of mandibular first molars in a Taiwan Chinese population.

    abstract：AIM:To investigate the root form and canal morphology of mandibular first molar teeth in a Taiwan Chinese population. METHODOLOGY:A total of 183 mandibular first molars were collected and examined visually through a dissecting microscope after rendering the teeth transparent. The number of roots, number of canals and ...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2009.01619.x

    authors： Chen G,Yao H,Tong C

    更新日期：2009-11-01 00:00:00

  • Effect of simvastatin on kinetics of osteoprotegrin/receptor activator nuclear kappa B Ligand mRNA expression in periapical lesions.

    abstract：AIM:To evaluate the therapeutic effect of Simvastatin on apical periodontitis in rats by assessing the osteoblast production of receptor activator of nuclear factor-Kappa B Ligand (RANKL) and Osteoprotegerin (OPG) cytokines that are essential for bone resorption. METHODOLOGY:Twenty-five healthy 8- to 10-week-old male ...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12101

    authors： Shadmehr E,Khademi A

    更新日期：2013-11-01 00:00:00

  • A laboratory assessment of coronal bacterial leakage in root canals filled with new and conventional sealers.

    abstract：AIM:To evaluate the resistance to ex vivo bacterial leakage over a 40-day period of root canal fillings with five new root canal sealers: RC Sealer, Epiphany, EndoREZ, GuttaFlow and Acroseal, compared with Apexit, AH Plus and RoekoSeal. METHODOLOGY:One hundred and forty-four single rooted human teeth were divided rand...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2008.01509.x

    authors： Eldeniz AU,Ørstavik D

    更新日期：2009-04-01 00:00:00

  • Evaluation of the radiopacity of calcium hydroxide- and glass-ionomer-based root canal sealers.

    abstract：AIM:To evaluate the radiopacity of calcium hydroxide-based root canal sealers (Acroseal, Sealapex and Sealer 26), a glass-ionomer-based sealer (Activ GP Sealer) and a zinc oxide and eugenol-based sealer (Intrafill). METHODOLOGY:Five disc-shaped specimens (10 x 1 mm) were fabricated from each material, according to the...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2007.01309.x

    authors： Tanomaru-Filho M,Jorge EG,Tanomaru JM,Gonçalves M

    更新日期：2008-01-01 00:00:00

  • Allergy to sodium hypochlorite during root canal therapy: a case report.

    abstract：:Sodium hypochlorite (NaOCl), is the most popular irrigation solution used in root canal treatment but it is known to be an irritant to vital tissues. There have been many case reports dealing with toxic effects of this material. Although the allergic potential of NaOCl has been described in the medical literature, onl...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.1994.tb00247.x

    authors： Calişkan MK,Türkün M,Alper S

    更新日期：1994-05-01 00:00:00

  • Impact of remaining zinc oxide-eugenol-based sealer on the bond strength of a resinous sealer to dentine after root canal retreatment.

    abstract：AIM:To evaluate the bond strength of a resin-based sealer (AH Plus) to root canal dentine after the removal of a zinc oxide-eugenol-based sealer (Endofill), using different retreatment techniques. METHODOLOGY:The root canals of sixty-four maxillary incisors were prepared with ProTaper and filled with Endofill/gutta-pe...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12170

    authors： Rached-Junior FJ,Sousa-Neto MD,Souza-Gabriel AE,Duarte MA,Silva-Sousa YT

    更新日期：2014-05-01 00:00:00

  • The influence of ultrasound in removing intraradicular posts.

    abstract：:Thirty single-rooted teeth were prepared to receive cast posts. After cementation of the post the teeth were divided into three groups. Group I did not receive any treatment, whereas the posts in groups II and III were treated with an ultrasonic device, for 2 min and 5 min, respectively. The force required for post re...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.1995.tb00157.x

    authors： Berbert A,Filho MT,Ueno AH,Bramante CM,Ishikiriama A

    更新日期：1995-01-01 00:00:00

  • Long-term sealing ability of Resilon apical root-end fillings.

    abstract：AIM:To evaluate ex vivo the long-term sealing ability of the SE Resilon Epiphany system as an apical root-end filling material. METHODOLOGY:A total of 60 standardized horizontal bovine root sections were divided into three groups filled with either gutta-percha with AH 26, tooth-coloured mineral trioxide aggregate (MT...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2009.01583.x

    authors： De Bruyne MA,De Moor RJ

    更新日期：2009-10-01 00:00:00

  • A preliminary study of the percentage of gutta-percha-filled area in the apical canal filled with vertically compacted warm gutta-percha.

    abstract：AIM:The aim of this study was to determine the influence of the width of apical root canals and the depth of heat application during warm vertical compaction on the percentage of gutta-percha-filled area (PGFA) in the apical root canal. METHODOLOGY:Two groups of extracted human canines (total 60) were instrumented and...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1046/j.1365-2591.2002.00522.x

    authors： Wu M-,van der Sluis LW,Wesselink PR

    更新日期：2002-06-01 00:00:00

  • Effectiveness in cleaning oval-shaped root canals using Anatomic Endodontic Technology, ProFile and manual instrumentation: a scanning electron microscopic study.

    abstract：AIM:To compare in vitro the cleanliness of root canal walls in oval-shaped root canals following automated or manual instrumentation. METHODOLOGY:Forty-five oval-shaped single-rooted maxillary and mandibular premolars with straight canals were divided into three groups of 15. Automated canal preparation was performed ...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2005.00938.x

    authors： Zmener O,Pameijer CH,Banegas G

    更新日期：2005-06-01 00:00:00

  • European Society of Endodontology position statement: Management of deep caries and the exposed pulp.

    abstract：:This position statement on the management of deep caries and the exposed pulp represents the consensus of an expert committee, convened by the European Society of Endodontology (ESE). Preserving the pulp in a healthy state with sustained vitality, preventing apical periodontitis and developing minimally invasive biolo...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.13080

    authors： European Society of Endodontology (ESE) developed by:.,Duncan HF,Galler KM,Tomson PL,Simon S,El-Karim I,Kundzina R,Krastl G,Dammaschke T,Fransson H,Markvart M,Zehnder M,Bjørndal L

    更新日期：2019-07-01 00:00:00

  • Quantitative microleakage study on a new retrograde filling technique.

    abstract：:An in vitro endodontic leakage model was used to compare the sealing ability of conventional retrograde amalgam fillings with a new retrograde filling technique by measuring dye leakage quantitatively. The new technique consisted of retrograde preparation of the root canal using the Endocursor, an endodontic handpiece...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.1990.tb00856.x

    authors： Wu MK,Kean SD,Kersten HW

    更新日期：1990-09-01 00:00:00

  • The potential of a surface pre-reacted glass root canal dressing for treating apical periodontitis in rats.

    abstract：AIM:To evaluate the efficacy of a prototype root canal dressing containing surface pre-reacted glass-ionomer (S-PRG) fillers on repairing induced periapical lesions in a rat model. Calcium hydroxide [Ca(OH)2 ] was applied as a comparison in the healing process. METHODOLOGY:The pulp chambers of the maxillary first mola...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.13414

    authors： Xiong B,Shirai K,Matsumoto K,Abiko Y,Furuichi Y

    更新日期：2021-02-01 00:00:00

  • Push-out strength of root fillings with or without thermomechanical compaction.

    abstract：AIM:To evaluate the influence of thermomechanical compaction (Tagger's hybrid technique - THT) on the push-out strength of several root filling materials to root dentine. METHODOLOGY:Root canals of eighty roots in human canines were prepared with the ProTaper system and filled with one of the following materials, usin...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2012.02039.x

    authors： Carneiro SM,Sousa-Neto MD,Rached FA Jr,Miranda CE,Silva SR,Silva-Sousa YT

    更新日期：2012-09-01 00:00:00

  • A proposal for using contralateral teeth to provide well-balanced experimental groups for endodontic studies.

    abstract：AIM:To develop a suitable protocol for screening extracted teeth so as to create anatomically well-balanced experimental groups for endodontic studies. METHODOLOGY:Sixty pairs (120 teeth) of contralateral premolars (CLPs) were collected. The evaluation of samples for anatomical features was performed in the following ...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12553

    authors： Xu J,Shao MY,Pan HY,Lei L,Liu T,Cheng L,Hu T,Dummer PM

    更新日期：2016-10-01 00:00:00

  • Influence of nickel-titanium rotary systems with varying tapers on the biomechanical behaviour of maxillary first premolars under occlusal forces: a finite element analysis study.

    abstract：AIM:To evaluate the effect of three nickel-titanium (Ni-Ti) rotary systems with varying tapers on stress distribution and to analyse potential fracture patterns as well as the volume of fracture-susceptible regions in two-rooted maxillary premolars. METHODOLOGY:The root canals of three single-rooted premolars were pre...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12770

    authors： Askerbeyli Örs S,Serper A

    更新日期：2018-05-01 00:00:00

  • Gingival and bone necrosis caused by accidental sodium hypochlorite injection instead of anaesthetic solution.

    abstract：AIM:To report clinical complications (pain, necrotic gingival tissue and bone sequestration) resulting from accidental injection of sodium hypochlorite. SUMMARY:Root canal treatment is a routine clinical procedure with few reported complications. Sodium hypochlorite (NaOCl) is commonly used as an irrigant during the p...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2007.01340.x

    authors： Pontes F,Pontes H,Adachi P,Rodini C,Almeida D,Pinto D Jr

    更新日期：2008-03-01 00:00:00

  • Bacterial localization and viability assessment in human ex vivo dentinal tubules by fluorescence confocal laser scanning microscopy.

    abstract：AIM:To develop a convenient method for the localization and quantification of live and dead bacteria in human ex vivo mineralized dentinal tubules. METHODOLOGY:The roots from human single-rooted teeth (n = 12) were infected with Enterococcus faecalis V583 and either treated with calcium hydroxide paste or left untreat...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2011.01867.x

    authors： Parmar D,Hauman CH,Leichter JW,McNaughton A,Tompkins GR

    更新日期：2011-07-01 00:00:00

  • Scanning electron microscope appearances of Lightspeed instruments used clinically: a pilot study.

    abstract：:The cutting heads of the first 18 instruments in six sets of clinically used Lightspeed instruments (sizes 20-65) were examined in a scanning electron microscope (SEM). Three sets had been used by full-time faculty and discarded as follows: instrument sizes 20-32.5 after 18 treated root canals; instrument sizes 35-47....

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：

    authors： Marending M,Lutz F,Barbakow F

    更新日期：1998-01-01 00:00:00

  • Protective device to reduce aerosol dispersion in dental clinics during the COVID-19 pandemic.

    abstract：AIM:To describe the use of a new protective device to reduce aerosol dispersion in dental clinics during the COVID-19 pandemic. METHODOLOGY:The device consists of a rigid translucent acrylic structure (methyl polymethacrylate), adjusted to the dental chair, involving the patient's head, neck and chest. There is also a...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.13373

    authors： Teichert-Filho R,Baldasso CN,Campos MM,Gomes MS

    更新日期：2020-11-01 00:00:00