Abstract:
AIM:To evaluate the efficacy of a prototype root canal dressing containing surface pre-reacted glass-ionomer (S-PRG) fillers on repairing induced periapical lesions in a rat model. Calcium hydroxide [Ca(OH)2 ] was applied as a comparison in the healing process. METHODOLOGY:The pulp chambers of the maxillary first molars in 64 male Wistar rats aged 16 weeks were opened to induce periapical lesions. After 28 days, the mesial canal of each tooth was prepared, irrigated with 2.5% sodium hypochlorite only (control group: irrigation) or followed by the respective dressing [Ca(OH)2 group, irrigation + Ca(OH)2 ; S-PRG group, irrigation + S-PRG] and restored with composite resin for 3 or 7 days (10/group). Four rats with healthy molars were used as blank controls. Descriptive analysis of the periapical radiographs, haematoxylin and eosin staining and immunohistochemical observation was performed 3 and 7 days after treatment. The periapical grey value, CD68 macrophages and osteoclasts (cathepsin-K) were quantified and statistically analysed with Tukey's honest significant difference test. A significant difference was achieved when P values were <0.05. RESULTS:S-PRG and Ca(OH)2 dressings were associated with increased periapical grey values and inhibited osteoclast activity at 3 and 7 days; a significant difference in radiographic results and the number of osteoclasts was obtained at 3 and 7 days compared with the control group (P < 0.05). Reparative tissue was observed histologically in the space of the periapical resorbed necrotic area after S-PRG and Ca(OH)2 treatment for 3 and 7 days. The number of macrophages was significantly decreased at 3 and 7 days in the S-PRG and Ca(OH)2 specimens when compared with the controls (P < 0.05). CONCLUSIONS:In a rat experimental model, the S-PRG root canal dressing was comparable to Ca(OH)2 in promoting the healing of experimentally induced periapical lesions. S-PRG paste has the potential to be used as an alternative intracanal dressing in teeth with apical periodontitis.
journal_name
Int Endod Jjournal_title
International endodontic journalauthors
Xiong B,Shirai K,Matsumoto K,Abiko Y,Furuichi Ydoi
10.1111/iej.13414subject
Has Abstractpub_date
2021-02-01 00:00:00pages
255-267issue
2eissn
0143-2885issn
1365-2591journal_volume
54pub_type
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journal_title:International endodontic journal
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journal_title:International endodontic journal
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doi:10.1046/j.1365-2591.2002.00522.x
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pub_type: 杂志文章,meta分析
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.1991.tb00131.x
更新日期:1991-07-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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更新日期:2018-04-01 00:00:00
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journal_title:International endodontic journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章,meta分析,评审
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更新日期:2003-09-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2006.01143.x
更新日期:2006-10-01 00:00:00
abstract::CLINICAL TECHNIQUE: It is generally accepted that the success of root-canal treatment is mainly dependent on the proper cleaning, shaping and hermetic obturation of root canals. Obturation of the root canal is of importance as 60% of endodontic failures are attributable to incomplete obliteration of the root-canal sys...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1046/j.1365-2591.1999.00180.x
更新日期:1999-01-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2591.2003.00637.x
更新日期:2003-03-01 00:00:00