CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis.

abstract：:The plant Mentzelia pumila (family Loasaceae) has leaves and stems densely covered with tiny hooked trichomes. The structures entrap and kill insects and therefore are most probably protective. But they are also maladaptive in that they incapacitate a coccinellid beetle (Hippodamia convergens) that preys upon an aphid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisner T,Eisner M,Hoebeke ER

更新日期：1998-04-14 00:00:00

abstract：:Chronic morphine administration is associated with the development of tolerance, both clinically and in animal models. Many assume that tolerance is a continually progressive response to chronic opioid dosing. However, clinicians have long appreciated the ability to manage cancer pain in patients for months on stable ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Faskowitz AJ,Rossi GC,Xu M,Lu Z,Pan YX,Pasternak GW

更新日期：2015-01-06 00:00:00

abstract：:Understanding molecular mechanisms in the context of living cells requires the development of new methods of in vivo biochemical analysis to complement established in vitro biochemistry. A critically important molecular mechanism is genetic recombination, required for the beneficial reassortment of genetic information...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cockram CA,Filatenkova M,Danos V,El Karoui M,Leach DR

更新日期：2015-08-25 00:00:00

abstract：:Ice-core records show that climate changes in the past have been large, rapid, and synchronous over broad areas extending into low latitudes, with less variability over historical times. These ice-core records come from high mountain glaciers and the polar regions, including small ice caps and the large ice sheets of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alley RB

更新日期：2000-02-15 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) knockout mice raised in the laboratory of Fujii-Kuriyama have been under investigation for several years because of the presence in their urinary bladder of large, yellowish stones. The stones are composed of uric acid and become apparent in the bladders as tiny stones when mice are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler R,Inzunza J,Suzuki H,Fujii-Kuriyama Y,Warner M,Gustafsson JÅ

更新日期：2012-01-24 00:00:00

abstract：:Transcription antitermination by lambda N gene product is affected in a mutant Escherichia coli with altered ribosomal protein S10, caused by the nusE71 mutation. To study the role of translation in antitermination, we have fused the phage nutR locus, the site of action of N, with the lac regulatory region. We have mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren F,Das A

更新日期：1984-06-01 00:00:00

abstract：:The emergence of Vibrio cholerae O139 Bengal during 1992-1993 was associated with large epidemics of cholera in India and Bangladesh and, initially, with a total displacement of the existing V. cholerae O1 strains. However, the O1 strains reemerged in 1994 and initiated a series of disappearance and reemergence of eit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faruque SM,Sack DA,Sack RB,Colwell RR,Takeda Y,Nair GB

更新日期：2003-02-04 00:00:00

abstract：:BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynch RG,Graff RJ,Sirisinha S,Simms ES,Eisen HN

更新日期：1972-06-01 00:00:00

abstract：:A role for Notch in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that Notch is important in the development of neural ultrastructu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Presente A,Boyles RS,Serway CN,de Belle JS,Andres AJ

更新日期：2004-02-10 00:00:00

abstract：:Intracellular recordings were obtained from vagal neurons and their response to oxytocin was investigated in slices from the rat and the guinea pig brainstem. After recording, Lucifer yellow was injected into the cells to verify their localization within the dorsal motor nucleus of the vagus nerve (dmnX). In the rat, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raggenbass M,Dubois-Dauphin M,Charpak S,Dreifuss JJ

更新日期：1987-06-01 00:00:00

abstract：:We applied an innovation framework to sustainable livestock development research projects in Africa and Asia. The focus of these projects ranged from pastoral systems to poverty and ecosystems services mapping to market access by the poor to fodder and natural resource management to livestock parasite drug resistance....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kristjanson P,Reid RS,Dickson N,Clark WC,Romney D,Puskur R,Macmillan S,Grace D

更新日期：2009-03-31 00:00:00

abstract：:Activins and inhibins, members of the type beta transforming growth factor superfamily of growth regulatory proteins, are produced in multiple tissues and affect diverse physiologic processes. Using embryonic stem cell technology, we previously demonstrated that inhibin can function as a gonadal tumor suppressor. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matzuk MM,Finegold MJ,Mather JP,Krummen L,Lu H,Bradley A

更新日期：1994-09-13 00:00:00

abstract：:Poly(A)+ mRNA was isolated from the brains of C57BL/6J (B6), DBA/2J (D2), and F1 hybrid mice (B6 X D2) of 16-17 days of age. The yield of polysomal RNA, both poly(A)+ and poly(A)-, from the three strains of mice was comparable. When translated in vitro in a reticulocyte lysate system, the mRNA preparations had the sam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miskimins R,Ebato H,Seyfried TN,Yu RK

更新日期：1986-03-01 00:00:00

abstract：:Sparse 3T3 cells, in excess serum, become quiescent in the early G(1) (or G(0)) phase of the cell cycle if the cells are cultured in low concentrations of amino acids, glucose, or phosphate ion. These quiescent cells then initiate DNA synthesis if the concentration of the limiting nutrient is increased. In normal medi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holley RW,Kiernan JA

更新日期：1974-08-01 00:00:00

abstract：:Patients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with a median survival of less than 8 months and a 5-year survival of <10%. Contributing to this poor prognosis is the fact that these patients generally do not tolerate standard heart failure therapies. The molecular mechanisms unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi J,Guan J,Jiang B,Brenner DA,Del Monte F,Ward JE,Connors LH,Sawyer DB,Semigran MJ,Macgillivray TE,Seldin DC,Falk R,Liao R

更新日期：2010-03-02 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) viral DNA synthesis in quiescent and activated peripheral blood lymphocytes (PBLs) was studied. Incomplete viral DNA (previously demonstrated to be associated with HIV-1 virions) is carried by HIV-1 virions into quiescent and activated PBLs, contributing to the formation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao WY,Cara A,Gallo RC,Lori F

更新日期：1993-10-01 00:00:00

abstract：:Combinatorial antibody libraries have the potential to display the entire immunological record of an individual, allowing one to detect and recover any antibody ever made, irrespective of whether it is currently being produced. We have termed this the "fossil record" of an individual's antibody response. To determine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felding-Habermann B,Lerner RA,Lillo A,Zhuang S,Weber MR,Arrues S,Gao C,Mao S,Saven A,Janda KD

更新日期：2004-12-07 00:00:00

abstract：:The Cercospora nicotianae SOR1 (singlet oxygen resistance) gene was identified previously as a gene involved in resistance of this fungus to singlet-oxygen-generating phototoxins. Although homologues to SOR1 occur in organisms in four kingdoms and encode one of the most highly conserved proteins yet identified, the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ehrenshaft M,Bilski P,Li MY,Chignell CF,Daub ME

更新日期：1999-08-03 00:00:00

abstract：:Signal peptides of membrane proteins are cleaved by endoplasmic reticulum-resident signal peptidase, and thus, are not present on mature membrane proteins. Here, we report that, contrary to the paradigm, the signal peptide of ruminant CD18, the beta-subunit of beta(2)-integrins, is not cleaved. Intriguingly, the intac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shanthalingam S,Srikumaran S

更新日期：2009-09-08 00:00:00

abstract：:The major histocompatibility complex-encoded class I molecule, a noncovalent dimer of a polymorphic 45-kDa heavy chain and a nonpolymorphic 12-kDa beta 2-microglobulin (beta 2m) light chain, binds peptide antigen prior to its interaction with T-cell antigen receptors. We report here that the binding in aqueous solutio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyd LF,Kozlowski S,Margulies DH

更新日期：1992-03-15 00:00:00

abstract：:Murine Ly-6-encoded molecules play an important role in the antigen-independent activation of lymphocytes. We have described the cloning of a cDNA encoding the protein component of an Ly-6 molecule. Hybridization studies indicated that this cDNA identified multiple DNA fragments on Southern blots. The banding pattern ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LeClair KP,Rabin M,Nesbitt MN,Pravtcheva D,Ruddle FH,Palfree RG,Bothwell A

更新日期：1987-03-01 00:00:00

abstract：:Transcription factors (TFs) are primary regulators of gene expression in cells, where they bind specific genomic target sites to control transcription. Quantitative measurements of TF-DNA binding energies can improve the accuracy of predictions of TF occupancy and downstream gene expression in vivo and shed light on h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le DD,Shimko TC,Aditham AK,Keys AM,Longwell SA,Orenstein Y,Fordyce PM

更新日期：2018-04-17 00:00:00

abstract：:Functional transcription elongation complexes can be formed by adding RNA polymerase in trans to a preformed nucleic acid construct. This construct consists of a double-stranded DNA fragment that contains a noncomplementary (permanent DNA bubble) region into which an RNA primer oligonucleotide has been hybridized. By ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daube SS,Hart CR,von Hippel PH

更新日期：1994-09-27 00:00:00

abstract：:The DNA in chromatin of isolated thymus nuclei, and in two different preparations of deoxyribonucleoprotein extracted from chromatin, has been digested with DNase. By variation of the time of reaction and the concentration of enzyme, and by comparison of the action of the enzyme on (protein-free) DNA with its action o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirsky AE

更新日期：1971-12-01 00:00:00

abstract：:The qualities of perception depend not only on the sensory inputs but also on the brain state before stimulus presentation. Although the collective evidence from neuroimaging studies for a relation between prestimulus state and perception is strong, the interpretation in the context of sensory computations or decision...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kayser SJ,McNair SW,Kayser C

更新日期：2016-04-26 00:00:00

abstract：:The harvest of wildlife for human consumption is valued at several billion dollars annually and provides an essential source of meat for hundreds of millions of rural people living in poverty. This harvest is also considered among the greatest threats to biodiversity throughout Africa, Asia, and Latin America. Economi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brashares JS,Golden CD,Weinbaum KZ,Barrett CB,Okello GV

更新日期：2011-08-23 00:00:00

abstract：:Kirsten sarcoma virus (Ki-MSV) and Harvey sarcoma virus (Ha-MSV) are mouse-rat recombinant viruses that were originally isolated by experimental inoculation of rats with helper-independent mouse type C viruses. We have recently identified in cells transformed by Ki-MSV or Ha-MSV, a phosphoprotein, p21, coded for by Ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young HA,Shih TY,Scolnick EM,Rasheed S,Gardner MB

更新日期：1979-07-01 00:00:00

abstract：:The Toll/IL-1 receptor (TIR) domains are crucial signaling modules during innate immune responses involving the Toll-like receptors (TLRs) and IL-1 receptor (IL-1R). Myeloid differential factor 88 (MyD88) is a central TIR domain-containing adapter molecule responsible for nearly all TLR-mediated signaling and is targe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snyder GA,Cirl C,Jiang J,Chen K,Waldhuber A,Smith P,Römmler F,Snyder N,Fresquez T,Dürr S,Tjandra N,Miethke T,Xiao TS

更新日期：2013-04-23 00:00:00

abstract：:The discovery of high-temperature superconductivity in iron pnictides raised the possibility of an unconventional superconducting mechanism in multiband materials. The observation of Fermi-surface (FS)-dependent nodeless superconducting gaps suggested that inter-FS interactions may play a crucial role in superconducti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terashima K,Sekiba Y,Bowen JH,Nakayama K,Kawahara T,Sato T,Richard P,Xu YM,Li LJ,Cao GH,Xu ZA,Ding H,Takahashi T

更新日期：2009-05-05 00:00:00

abstract：:Involution of the thymus is accompanied by a decline in the number of thymic epithelial cells (TECs) and a severely restricted peripheral repertoire of T-cell specificities. TECs are essential for T-cell differentiation; they originate from a bipotent progenitor that gives rise to cells of cortical (cTEC) and medullar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rode I,Boehm T

更新日期：2012-02-28 00:00:00