Dendritic cell depletion and repopulation in the lung after irradiation and bone marrow transplantation in mice.

abstract：:The mechanisms used by alveolar type I pneumocytes for maintenance of the lipid homeostasis necessary to sustain these large squamous cells are unknown. The processes may involve the ATP-binding cassette transporter A1 (ABCA1), a transport protein shown to be crucial in apolipoprotein A-I (apoA-I)-mediated mobilizatio...

journal_title：American journal of respiratory cell and molecular biology

authors： Bates SR,Tao JQ,Yu KJ,Borok Z,Crandall ED,Collins HL,Rothblat GH

更新日期：2008-03-01 00:00:00

abstract：:Alveolar macrophages (AMs) play an important role in the regulation of the local immune reactivity in the lung. It was previously shown that exposure of rats to mild inescapable electrical footshock stress (20 min, 4 shocks/min, 5 s/shock, 0.8 mAmp) leads to apparent changes in the activity of AMs upon stimulation, re...

journal_title：American journal of respiratory cell and molecular biology

authors： Broug-Holub E,Persoons JH,Schornagel K,Mastbergen SC,Kraal G

更新日期：1998-11-01 00:00:00

abstract：:Over one-third of lung recipients have preexisting antibodies against lung-restricted antigens: collagen (Col) type V and K-α1 tubulin (KAT). Although clinical studies have shown association of these antibodies with primary graft dysfunction (PGD), their biological significance remains unclear. We tested whether preex...

journal_title：American journal of respiratory cell and molecular biology

authors： Bharat A,Chiu S,Zheng Z,Sun H,Yeldandi A,DeCamp MM,Perlman H,Budinger GR,Mohanakumar T

更新日期：2016-10-01 00:00:00

abstract：:Lung transplantation remains the only therapeutic option for many patients suffering from end-stage pulmonary disease. Long-term success after lung transplantation is severely limited by the development of bronchiolitis obliterans. The murine heterotopic tracheal transplantation model has been widely used for studies ...

journal_title：American journal of respiratory cell and molecular biology

authors： Okazaki M,Gelman AE,Tietjens JR,Ibricevic A,Kornfeld CG,Huang HJ,Richardson SB,Lai J,Garbow JR,Patterson GA,Krupnick AS,Brody SL,Kreisel D

更新日期：2007-12-01 00:00:00

abstract：:Hypervascularity is known as an important element of airway remodeling in bronchial asthma. However, it remains obscure how allergic inflammation relates to angiogenesis in the lung. In this study, we examined the in vitro effects of inflammatory cytokines on endothelial cell functions, particularly angiogenesis. Huma...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsuda A,Fukuda S,Matsumoto K,Saito H

更新日期：2008-02-01 00:00:00

abstract：:Interstitial lung disease is a devastating disease in humans that can be further complicated by the development of secondary pulmonary hypertension. Accumulating evidence indicates that the oxidant superoxide can contribute to the pathogenesis of both interstitial lung disease and pulmonary hypertension. We used a mod...

journal_title：American journal of respiratory cell and molecular biology

authors： Van Rheen Z,Fattman C,Domarski S,Majka S,Klemm D,Stenmark KR,Nozik-Grayck E

更新日期：2011-04-01 00:00:00

abstract：:We examined the contribution of the leukocyte function-associated antigen (LFA-1) in a murine model of lung inflammation determined by exposure to the thermophilic actinomycete Faeni rectivirgula. The exposure generated a large influx of cells in the bronchoalveolar space and in the lung parenchyma, as seen from enhan...

journal_title：American journal of respiratory cell and molecular biology

authors： Denis M,Bisson D

更新日期：1994-05-01 00:00:00

abstract：:Increases in inflammatory-cell progenitors have been demonstrated in the bone marrow (BM) after inhalation of Ascaris suum in dogs at the time of allergen-induced airway hyperresponsiveness (AHR). The aim of this study was to evaluate the effect of allergen challenge on trafficking of inflammatory cells and their prog...

journal_title：American journal of respiratory cell and molecular biology

authors： Wood LJ,Inman MD,Denburg JA,O'Byrne PM

更新日期：1998-06-01 00:00:00

abstract：:Specific changes in composition and content of lung extracellular matrix (ECM) proteoglycans (PGs) and hyaluronan (HA) have been observed during the acute response to damage in several forms of injury including infant respiratory distress syndrome (IRDS). These ECM components are thought to modulate the healing respon...

journal_title：American journal of respiratory cell and molecular biology

authors： Juul SE,Krueger RC Jr,Scofield L,Hershenson MB,Schwartz NB

更新日期：1995-12-01 00:00:00

abstract：:Exposure to particulate air pollution is associated with increased cardiopulmonary morbidity and mortality, although the pathogenic mechanisms are poorly understood. We previously demonstrated that particulate matter (PM) exposure triggers massive oxidative stress in vascular endothelial cells (ECs), resulting in the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Wang T,Wang L,Zaidi SR,Sammani S,Siegler J,Moreno-Vinasco L,Mathew B,Natarajan V,Garcia JG

更新日期：2012-10-01 00:00:00

abstract：:Gene therapy requires the presence of a robust and yet small promoter to drive high-level expression of desired proteins. In comparative analysis, we investigated the promoter strength of the CTP:phosphocholine cytidylyltransferase promoter (CCT alpha) with other commonly used promoters, which were all cloned into a s...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou J,You Y,Zabner J,Ryan AJ,Mallampalli RK

更新日期：2004-01-01 00:00:00

abstract：:It had been thought that the central molecular event in the malignant transformation of a cell is the mutation of certain oncogenes-and the resultant dysregulated activation of their encoded proteins. During the past decade, however, it has become clear that alteration of the activity of the protein products of tumor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Weintraub SJ

更新日期：1996-08-01 00:00:00

abstract：:Degradation of preexisting and newly synthesized extracellular matrix is thought to play an important role in tissue remodeling. The current study evaluated whether thrombin and TNF-alpha/IL-1beta could collaboratively induce collagen degradation by human fetal lung fibroblasts (HFL-1) and adult bronchial fibroblasts ...

journal_title：American journal of respiratory cell and molecular biology

authors： Fang Q,Liu X,Al-Mugotir M,Kobayashi T,Abe S,Kohyama T,Rennard SI

更新日期：2006-12-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a devastating disease without effective treatment. Despite decades of research and the development of novel treatments, PAH remains a fatal disease, suggesting an urgent need for better understanding of the pathogenesis of PAH. Recent studies suggest that microRNAs (miRNAs) are...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhou G,Chen T,Raj JU

更新日期：2015-02-01 00:00:00

abstract：:Lower respiratory tract infection by respiratory syncytial virus (RSV) is a frequent cause of acute lung injury in young children and infants. Studies in adults and animals suggest that tumor necrosis factor receptor (TNFR) ligands may mediate lung injury by causing apoptosis of epithelial cells. The main goal of the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Bem RA,Bos AP,Wösten-van Asperen RM,Bruijn M,Lutter R,Sprick MR,van Woensel JB

更新日期：2010-06-01 00:00:00

abstract：:Gene therapy is the treatment of any disorder or pathophysiologic state based upon the transfer of genetic information. The lung represents a major target of gene therapy for the treatment of genetic disorders such as cystic fibrosis and alpha 1-antitrypsin deficiency. Other diseases are also being targeted, including...

journal_title：American journal of respiratory cell and molecular biology

authors： Curiel DT,Pilewski JM,Albelda SM

更新日期：1996-01-01 00:00:00

abstract：:Neutrophil elastase (NE) is a major inflammatory mediator in cystic fibrosis (CF) that is a robust predictor of lung disease progression. NE directly causes airway injury via protease activity, and propagates persistent neutrophilic inflammation by up-regulation of neutrophil chemokine expression. Despite its key role...

journal_title：American journal of respiratory cell and molecular biology

authors： Griffin KL,Fischer BM,Kummarapurugu AB,Zheng S,Kennedy TP,Rao NV,Foster WM,Voynow JA

更新日期：2014-04-01 00:00:00

abstract：:The lung epithelium constitutes a selective barrier that separates the airways from the aqueous interstitial compartment. Regulated barrier function controls water and ion transport across the epithelium and is essential for maintaining lung function. Tight junctions (TJs) seal the epithelial barrier and determine the...

journal_title：American journal of respiratory cell and molecular biology

authors： Kielgast F,Schmidt H,Braubach P,Winkelmann VE,Thompson KE,Frick M,Dietl P,Wittekindt OH

更新日期：2016-05-01 00:00:00

abstract：:Oxygen-mediated lung injury can stimulate a fibroproliferative response resulting in the alteration of the pulmonary extracellular matrix and subsequent scarring of parenchymal tissue. Fibronectin (FN), a component of the extracellular matrix, appears in increased quantities in fibrotic lung disease. Alveolar macropha...

journal_title：American journal of respiratory cell and molecular biology

authors： Sinkin RA,LoMonaco MB,Finkelstein JN,Watkins RH,Cox C,Horowitz S

更新日期：1992-11-01 00:00:00

abstract：:Glucocorticoids increase surfactant phosphatidylcholine synthesis, in part, by stimulating the rate regulatory enzyme CTP:cholinephosphate cytidylyltransferase. This enzyme exists in mammalian lung cytosol as an active lipoprotein form (H-form) and an inactive apoprotein (L-form) species. We administered betamethasone...

journal_title：American journal of respiratory cell and molecular biology

authors： Mallampalli RK,Walter ME,Peterson MW,Hunninghake GW

更新日期：1994-01-01 00:00:00

abstract：:Recent evidence suggests that the surface fluid secreted by human airway epithelial cells contains antimicrobial activity. The identification of the factor(s) responsible for the antibacterial activity in airway surface fluid may bring new insights into lung defense mechanisms and the pathogenesis of disease. Defensin...

journal_title：American journal of respiratory cell and molecular biology

authors： McCray PB Jr,Bentley L

更新日期：1997-03-01 00:00:00

abstract：:In bronchial asthma, eosinophils found in the airways have an enhanced inflammatory capacity. We hypothesized that, at least in part, changes in functional phenotype are due to the effect of transendothelial migration. To model in vivo eosinophil trafficking to the lung, we cultured human pulmonary microvascular endot...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamamoto H,Sedgwick JB,Vrtis RF,Busse WW

更新日期：2000-09-01 00:00:00

abstract：:FGFs (fibroblast growth factors) are major factors associated with the pathogenesis of pulmonary fibrosis. On the one hand, nintedanib, a tyrosine kinase inhibitor targeting several growth factor receptors, including the FGF receptor (FGFR), has been approved for the treatment of idiopathic pulmonary fibrosis. On the ...

journal_title：American journal of respiratory cell and molecular biology

authors： Morizumi S,Sato S,Koyama K,Okazaki H,Chen Y,Goto H,Kagawa K,Ogawa H,Nishimura H,Kawano H,Toyoda Y,Uehara H,Nishioka Y

更新日期：2020-09-01 00:00:00

abstract：:A defining feature of acute lung injury (ALI) is the increased lung vascular permeability and alveolar flooding, which leads to associated morbidity and mortality. Specific therapies to alleviate the unremitting vascular leak in ALI are not currently clinically available; however, our prior studies indicate a protecti...

journal_title：American journal of respiratory cell and molecular biology

authors： Zhao Y,Gorshkova IA,Berdyshev E,He D,Fu P,Ma W,Su Y,Usatyuk PV,Pendyala S,Oskouian B,Saba JD,Garcia JG,Natarajan V

更新日期：2011-08-01 00:00:00

abstract：:Sufficient pulmonary surfactant production is required for the fetal-neonatal transition, especially in preterm infants. Neuregulin (NRG) and its transmembrane receptor ErbB4 positively regulate the onset of fetal surfactant synthesis. Details of this signaling process remain to be elucidated. ErbB4 is known to regula...

journal_title：American journal of respiratory cell and molecular biology

authors： Zscheppang K,Dörk T,Schmiedl A,Jones FE,Dammann CE

更新日期：2011-10-01 00:00:00

abstract：:The ability of Pseudomonas aeruginosa to form antibiotic-resistant biofilms is thought to account for the inability of current therapies to resolve bacterial infections in the lungs of patients with cystic fibrosis (CF). We recently described a system in which highly antibiotic-resistant P. aeruginosa biofilms grow on...

journal_title：American journal of respiratory cell and molecular biology

authors： Moreau-Marquis S,O'Toole GA,Stanton BA

更新日期：2009-09-01 00:00:00

abstract：:Transplantation of mesenchymal stem cells (MSCs) holds great promise in the repair of cigarette smoke (CS)-induced lung damage in chronic obstructive pulmonary disease (COPD). Because CS leads to mitochondrial dysfunction, we aimed to investigate the potential benefit of mitochondrial transfer from human-induced pluri...

journal_title：American journal of respiratory cell and molecular biology

authors： Li X,Zhang Y,Yeung SC,Liang Y,Liang X,Ding Y,Ip MS,Tse HF,Mak JC,Lian Q

更新日期：2014-09-01 00:00:00

abstract：:Laminins are heterotrimeric proteins that are secreted by the alveolar epithelium into the basement membrane, and their expression is altered in extracellular matrices from patients with pulmonary fibrosis. In a small number of patients with pulmonary fibrosis, we found that the normal basement membrane distribution o...

journal_title：American journal of respiratory cell and molecular biology

authors： Morales-Nebreda LI,Rogel MR,Eisenberg JL,Hamill KJ,Soberanes S,Nigdelioglu R,Chi M,Cho T,Radigan KA,Ridge KM,Misharin AV,Woychek A,Hopkinson S,Perlman H,Mutlu GM,Pardo A,Selman M,Jones JC,Budinger GR

更新日期：2015-04-01 00:00:00

abstract：:Mechanical ventilation with supraphysiological concentrations of oxygen (hyperoxia) is routinely used to treat patients with respiratory distress. However, a significant number of patients on ventilators exhibit enhanced susceptibility to infections and develop ventilator-associated pneumonia (VAP). Pseudomonas aerugi...

journal_title：American journal of respiratory cell and molecular biology

authors： Patel VS,Sitapara RA,Gore A,Phan B,Sharma L,Sampat V,Li JH,Yang H,Chavan SS,Wang H,Tracey KJ,Mantell LL

更新日期：2013-03-01 00:00:00

abstract：:Lung development is associated with a surge in surfactant phosphatidylcholine (PC) production to prepare the newborn for extrauterine breathing. This process is associated with a marked increase in the activity of the rate-regulatory surfactant enzyme, CTP:phosphocholine cytidylyltransferase (CCTalpha). To investigate...

journal_title：American journal of respiratory cell and molecular biology

authors： McCoy DM,Fisher K,Robichaud J,Ryan AJ,Mallampalli RK

更新日期：2006-09-01 00:00:00