Abstract：
:The P23H-1 rat strain carries a rhodopsin mutation frequently found in retinitis pigmentosa patients. We investigated the progressive degeneration of the inner retina in this strain, focussing on retinal ganglion cells (RGCs) fate. Our data show that photoreceptor death commences in the ventral retina, spreading to the whole retina as the rat ages. Quantification of the total number of RGCs identified by Fluorogold tracing and Brn3a expression, disclosed that the population of RGCs in young P23H rats is significantly smaller than in its homologous SD strain. In the mutant strain, there is also RGC loss with age: RGCs show their first symptoms of degeneration at P180, as revealed by an abnormal expression of cytoskeletal proteins which, at P365, translates into a significant loss of RGCs, that may ultimately be caused by displaced inner retinal vessels that drag and strangulate their axons. RGC axonal compression begins also in the ventral retina and spreads from there causing RGC loss through the whole retinal surface. These decaying processes are common to several models of photoreceptor loss, but show some differences between inherited and light-induced photoreceptor degeneration and should therefore be studied to a better understanding of photoreceptor degeneration and when developing therapies for these diseases.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
García-Ayuso D,Salinas-Navarro M,Agudo M,Cuenca N,Pinilla I,Vidal-Sanz M,Villegas-Pérez MPdoi
10.1016/j.exer.2010.10.003subject
Has Abstractpub_date
2010-12-01 00:00:00pages
800-10issue
6eissn
0014-4835issn
1096-0007pii
S0014-4835(10)00326-Xjournal_volume
91pub_type
杂志文章abstract：:High-mobility group Box-1 (HMGB1) is known to be released from injured cells and to induce an inflammatory response. Although HMGB1 was reported to mediate ischemia-reperfusion injury of the brain, its role in glutamate excitotoxicity of the retina remains controversial. Here, the authors demonstrated the evidence tha...
journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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更新日期：1985-03-01 00:00:00
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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更新日期：2004-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.exer.2010.05.017
更新日期：2010-08-01 00:00:00
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更新日期：2019-11-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1994.1026
更新日期：1994-03-01 00:00:00
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doi：10.1006/exer.2000.0952
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2013.08.003
更新日期：2013-11-01 00:00:00
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更新日期：2007-06-01 00:00:00
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更新日期：1987-10-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1006/exer.1993.1119
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journal_title：Experimental eye research
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更新日期：1993-01-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Experimental eye research
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更新日期：2011-12-01 00:00:00
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更新日期：2015-08-01 00:00:00
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journal_title：Experimental eye research
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更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1995-05-01 00:00:00
