Association of transfusion with postoperative bacterial infection.

abstract：:Muscle wasting in patients with sepsis, severe injury, and cancer is associated with increased transcription of several genes regulating different proteolytic pathways. The involvement of gene activation in muscle wasting suggests that transcription factors and nuclear cofactors play important roles in the regulation ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Aversa Z,Alamdari N,Hasselgren PO

更新日期：2011-03-01 00:00:00

abstract：:Gas-liquid chromatography (GLC) continues to find increasing applications in the characterization of microorganisms and the diseases associated with them. GLC has been used to characterize microorganisms through qualitative and quantitative analyses of cellular structural components and soluble extracts and metabolic ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Edman DC,Craven RB,Brooks JB

更新日期：1981-01-01 00:00:00

abstract：:The discovery of a G protein-coupled, calcium-sensing receptor (CaR) a decade ago and of diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical role in the maintenance of systemic calcium homeostasis. On the cell membrane of the chief cells of the parathyroid glands, the CaR "senses" t...

journal_title：Critical reviews in clinical laboratory sciences

authors： Tfelt-Hansen J,Brown EM

更新日期：2005-01-01 00:00:00

abstract：:A wide range of protein cancer biomarkers is currently recommended in international guidelines for monitoring the growth and regression of solid tumors. However, a number of these markers are also present in low concentrations in blood obtained from healthy individuals and from patients with benign diseases. In contra...

journal_title：Critical reviews in clinical laboratory sciences

authors： Kristiansen S,Nielsen D,Sölétormos G

更新日期：2014-06-01 00:00:00

abstract：:Cardiotoxicity, including acute and late-onset cardiotoxicity, is a well-known adverse effect of many types of antitumor agents. Early identification of patients with cardiotoxicity is important to ensure prompt treatment and minimize toxic effects. The etiology of chemotherapy-induced cardiotoxicity is multifactorial...

journal_title：Critical reviews in clinical laboratory sciences

authors： Cao L,Zhu W,Wagar EA,Meng QH

更新日期：2017-03-01 00:00:00

abstract：:Isoforms of the receptor for advanced glycation end-product (RAGE) protein, which lack the transmembrane and the signaling (soluble RAGE or sRAGE) domains are hypothesized to counteract the detrimental action of the full-length receptor by acting as a decoy, and they provide a potential tool to treat RAGE-associated d...

journal_title：Critical reviews in clinical laboratory sciences

authors： Steenbeke M,De Bruyne S,De Buyzere M,Lapauw B,Speeckaert R,Petrovic M,Delanghe JR,Speeckaert MM

更新日期：2020-07-15 00:00:00

abstract：:The red blood cell distribution width (RDW) is a simple and inexpensive parameter, which reflects the degree of heterogeneity of erythrocyte volume (conventionally known as anisocytosis), and is traditionally used in laboratory hematology for differential diagnosis of anemias. Nonetheless, recent evidence attests that...

journal_title：Critical reviews in clinical laboratory sciences

authors： Salvagno GL,Sanchis-Gomar F,Picanza A,Lippi G

更新日期：2015-01-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common age-related cancers among men. Various environmental and genetic factors are involved in the development and progression of PCa. In most cases, the primary symptoms of disease are not severe. Therefore, it is common for patients to be referred with severe clinical manife...

journal_title：Critical reviews in clinical laboratory sciences

authors： Ghayour-Mobarhan M,Ferns GA,Moghbeli M

更新日期：2020-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) constitute a heterogeneous group of autoantibodies that share the ability to bind phospholipids (PL) alone, protein-PL complexes, or PL-binding proteins. They have been detected in isolation, in association with autoimmune diseases such as systemic lupus erythematosus (SLE), and durin...

journal_title：Critical reviews in clinical laboratory sciences

authors： Vlachoyiannopoulos PG,Samarkos M,Sikara M,Tsiligros P

更新日期：2007-01-01 00:00:00

abstract：:The coupling of hematologic data with radionuclide studies of the spleen has provided information as to the functioning of the organ in a variety of disease states. The major radionuclide studies have been presented in terms of the type of information derivable and the various conditions that can result in fairly simi...

journal_title：Critical reviews in clinical laboratory sciences

authors： Spencer RP,Gupta SM

更新日期：1989-01-01 00:00:00

abstract：:Trypsinogens and PSTI/TATI/SPINK1 are expressed, usually together, at high levels by the pancreas but also by many other normal and malignant tissues. The present review describes studies on the expression and putative functions of trypsinogens and PSTI/TATI/SPINK1 in the human body. The clinical aspects are discussed...

journal_title：Critical reviews in clinical laboratory sciences

authors： Paju A,Stenman UH

更新日期：2006-01-01 00:00:00

abstract：:Our understanding of risk factors for atherogenesis has changed significantly over the last decade. In addition to better grasp of the mechanism of action of the "classic" (causal) risk factors, a number of potentially important new factors has emerged. In this review we briefly summarize the evidence of the relation ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Frohlich J,Dobiasova M,Lear S,Lee KW

更新日期：2001-10-01 00:00:00

abstract：:The genes of the human leukocyte antigen (HLA) region, the major histocompatibility complex (MHC) of humans, control a variety of functions involved in immune response and influence susceptibility to over 40 diseases. Theoretical studies in the development of models to determine the modes of inheritance of the HLA-ass...

journal_title：Critical reviews in clinical laboratory sciences

authors： Thomson G

更新日期：1995-01-01 00:00:00

abstract：:Iron deficiency is the most common micronutrient deficiency in the world and represents a major challenge for public health, notably in terms of morbidity and mortality. It remains largely under-diagnosed due to the low level of exploration and the absence of international harmonization for biological tests and thresh...

journal_title：Critical reviews in clinical laboratory sciences

authors： Cacoub P,Vandewalle C,Peoc'h K

更新日期：2019-12-01 00:00:00

abstract：:Cardiac diseases have been extensively studied following diabetes and altered metabolism has been implicated in its initiation. In this context, there is a shift from glucose utilization to predominantly fatty acid metabolism. We have focused on the micro- and macro-environments that the heart uses to provide fatty ac...

journal_title：Critical reviews in clinical laboratory sciences

authors： Puthanveetil P,Wan A,Rodrigues B

更新日期：2015-01-01 00:00:00

abstract：:Infants with very low birthweights (less than 1250g) are immunocompromised and have immature hematopoietic systems. They require frequent blood transfusions and have an increased susceptibility to infection. These very low birthweight infants who lack passively acquired antibody against CMV, acquire transfusion-associ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Adler SP

更新日期：1986-01-01 00:00:00

abstract：:Resveratrol and its naturally dimethylated analog, pterostilbene, show similar biological activities. However, the higher in vivo bioavailability of pterostilbene represents a fundamental advantage. The main focus of this review is on biomedical applications of pterostilbene. The metabolism and pharmacokinetics of thi...

journal_title：Critical reviews in clinical laboratory sciences

authors： Estrela JM,Ortega A,Mena S,Rodriguez ML,Asensi M

更新日期：2013-05-01 00:00:00

abstract：:Low molecular-mass plasma proteins play a key role in health and disease. Cystatin C is an endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a mole...

journal_title：Critical reviews in clinical laboratory sciences

authors： Mussap M,Plebani M

更新日期：2004-01-01 00:00:00

abstract：:The prevalence of secondary hypertension can be underestimated if appropriate tests are not performed. The importance of selecting patients with a high pre-test probability of secondary forms of hypertension is first discussed. The laboratory tests currently used for seeking a cause of hypertension are critically revi...

journal_title：Critical reviews in clinical laboratory sciences

authors： Rossi GP,Seccia TM,Pessina AC

更新日期：2007-01-01 00:00:00

abstract：:The constrained economic context leads laboratories to centralize their routine analyses on high-throughput platforms, to which blood collection tubes are sent from peripheral sampling sites that are sometimes distantly located. Providing biochemistry results as quickly as possible implies to consolidate the maximum n...

journal_title：Critical reviews in clinical laboratory sciences

authors： Lima-Oliveira G,Monneret D,Guerber F,Guidi GC

更新日期：2018-11-01 00:00:00

abstract：:Reviewed are the phosphorylation events reporting activation of protein kinases and the key substrates critical for the DNA damage signaling (DDS). These DDS events are detected immunocytochemically using phospho-specific Abs; flow cytometry or image-assisted cytometry provide the means to quantitatively assess them o...

journal_title：Critical reviews in clinical laboratory sciences

authors： Darzynkiewicz Z,Zhao H,Halicka HD,Rybak P,Dobrucki J,Wlodkowic D

更新日期：2012-09-01 00:00:00

abstract：:Allogeneic bone marrow transplantation now has an established place in the treatment of severe aplastic anemia and acute leukemia. Major problems to be overcome in transplantation in patients with aplastic anemia are marrow graft rejection and graft vs. host disease. Results are better in younger patients and in patie...

journal_title：Critical reviews in clinical laboratory sciences

authors： Weiden PL

更新日期：1983-01-01 00:00:00

abstract：:Serum gamma-glutamyl transferase (GGT) has been widely used as an index of liver dysfunction and marker of alcohol intake. The last few years have seen improvements in these areas and advances in understanding of its physiological role in counteracting oxidative stress by breaking down extracellular glutathione and ma...

journal_title：Critical reviews in clinical laboratory sciences

authors： Whitfield JB

更新日期：2001-08-01 00:00:00

abstract：:The kallikrein-related peptidases (KLKs) represent the largest family of serine proteases within the human genome and are expressed in various tissues. Although they regulate several important physiological functions, KLKs have also been implicated in numerous pathophysiological processes, including cancer. Growing ev...

journal_title：Critical reviews in clinical laboratory sciences

authors： Filippou PS,Karagiannis GS,Musrap N,Diamandis EP

更新日期：2016-08-01 00:00:00

abstract：:There have been numerous reports of spectrophotometric and volume problems caused by elevated levels of lipids in blood. The offending lipids, primarily triglycerides, not only cause turbidity leading to optical aberrations when added to analytical reagents, but also result in short-sampling errors leading to the meas...

journal_title：Critical reviews in clinical laboratory sciences

authors： Artiss JD,Zak B

更新日期：1987-01-01 00:00:00

abstract：:Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool...

journal_title：Critical reviews in clinical laboratory sciences

authors： De Bruyne S,Speeckaert MM,Delanghe JR

更新日期：2018-01-01 00:00:00

abstract：:Despite great progress in prevention strategies, pharmacotherapy and interventional treatment of coronary artery disease (CAD), cardiovascular events still constitute the leading cause of mortality and morbidity in the modern world. Traditional risk factors, including hypertension, diabetes mellitus, smoking, obesity,...

journal_title：Critical reviews in clinical laboratory sciences

authors： Krintus M,Kozinski M,Kubica J,Sypniewska G

更新日期：2014-10-01 00:00:00

abstract：:The CK-BB isoenzyme is ubiquitous in neoplastic tissue, but with low activity. Accordingly, it might be a nonspecific and insensitive tumor marker. Evaluation of BB isoenzyme in serum might indicate the extent of diseases or the response to therapy. The presence of CK-MB in patients with cancers may cause confusion wi...

journal_title：Critical reviews in clinical laboratory sciences

authors： Tsung JS

更新日期：1986-01-01 00:00:00

abstract：:Urinary nucleosides offer a number of useful laboratory and clinical applications in the study and analysis of leukemia. There are significant differences in the excretion of modified nucleosides between normal individuals and individuals with various forms of leukemia, as well as between leukemia patients at opposite...

journal_title：Critical reviews in clinical laboratory sciences

authors： Trewyn RW,Grever MR

更新日期：1986-01-01 00:00:00

abstract：:There have been numerous publications on the coagulopathy of cardiopulmonary bypass (CPB). This review provides an introduction to the history and main components of current CPB circuits and summarizes the current knowledge of pathogenesis, prevention, and treatment of the CPB coagulopathy. It encompasses an overview ...

journal_title：Critical reviews in clinical laboratory sciences

authors： Besser MW,Klein AA

更新日期：2010-12-01 00:00:00