Abstract：
:Allogeneic bone marrow transplantation now has an established place in the treatment of severe aplastic anemia and acute leukemia. Major problems to be overcome in transplantation in patients with aplastic anemia are marrow graft rejection and graft vs. host disease. Results are better in younger patients and in patients who have not been previously transfused. Newer approaches to the control of graft vs. host disease, for example total lymphoid irradiation and the immunosuppressive agent, cyclosporin A, hold promise for future progress. In patients with acute leukemia, the major clinical problems are early infections, recurrent leukemia, graft vs. host disease, and interstitial pneumonia. Both ultra-isolation and prophylactic granulocyte transfusions are able to decrease the incidence of early infections. Attempts to intensify the conditioning regimen have failed to decrease the incidence of recurrent leukemia, but transplantation earlier in the course of disease, particularly in patients with acute, nonlymphoblastic leukemia in first remission, have decreased the incidence of recurrent leukemia. Both acute and chronic forms of graft vs. host disease have been recognized. Acute graft vs. host disease continues to be a significant clinical problem, in spite of the use of Cyclosporin A. Chronic graft vs. host disease is being recognized earlier and treated successfully with immunosuppressive agents. Interstitial pneumonia, primarily secondary to cytomegalovirus, remains the major cause of death post-transplantation. In spite of these problems, however, patients with acute non-lymphoblastic leukemia in first remission have a 60% likelihood of remaining alive, free of disease following allogeneic marrow transplantation from an HLA identical sibling. Patients with acute leukemia who have relapsed who undergo allogeneic marrow transplantation have a longer survival than patients treated with conventional chemotherapy and even patients in relapse have a significant likelihood of cure following high-dose chemoradiotherapy and allogeneic marrow transplantation.
journal_name
Crit Rev Clin Lab Scijournal_title
Critical reviews in clinical laboratory sciencesauthors
Weiden PLdoi
10.3109/10408368309165762subject
Has Abstractpub_date
1983-01-01 00:00:00pages
173-86issue
3eissn
1040-8363issn
1549-781Xjournal_volume
19pub_type
杂志文章,评审abstract：:There have been major advances in our understanding of thrombosis and antithrombotic drugs. This review focuses on the molecular aspects of thrombus formation and antithrombotic therapy. Molecules involved in arterial thrombosis are derived from inflammatory cells in the atherosclerotic plaque and blood platelets. The...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360590951171
更新日期：2005-01-01 00:00:00
abstract：:Isoforms of the receptor for advanced glycation end-product (RAGE) protein, which lack the transmembrane and the signaling (soluble RAGE or sRAGE) domains are hypothesized to counteract the detrimental action of the full-length receptor by acting as a decoy, and they provide a potential tool to treat RAGE-associated d...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.1080/10408363.2020.1791045
更新日期：2020-07-15 00:00:00
abstract：:Fluoride has the potential to increase skeletal mass to a greater extent than any other pharmacologic agent, yet it has proven difficult to translate this into therapeutic benefit for patients with low bone mass in diseases such as osteoporosis. This apparent paradox can be explained in part by toxic actions of the io...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408369609083059
更新日期：1996-01-01 00:00:00
abstract：:Muscle wasting in patients with sepsis, severe injury, and cancer is associated with increased transcription of several genes regulating different proteolytic pathways. The involvement of gene activation in muscle wasting suggests that transcription factors and nuclear cofactors play important roles in the regulation ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.3109/10408363.2011.591365
更新日期：2011-03-01 00:00:00
abstract：:Most clinical chemical analytes vary in a random manner around a homeostatic set point. Replicate analyses of a series of specimens collected from a group of subjects allows estimation of analytical, within and between subject components of variation. The preferred experimental procedures and statistical methods for e...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368909106595
更新日期：1989-01-01 00:00:00
abstract：:High-density lipoprotein (HDL), the most abundant human plasma lipoprotein, plays a major role in reverse cholesterol transport, which recycles cholesterol from peripheral cells to the liver. HDL constitutes a heterogeneous group of particles differing in density, size, electrophoretic mobility, and apolipoprotein con...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408369609083060
更新日期：1996-01-01 00:00:00
abstract：:Hereditary hemochromatosis (HH) comprises a group of inherited disorders of iron metabolism that can result in progressive iron overload, morbidity, and mortality, generally in adulthood. HFE-related HH is the most common type of HH and will form the core of this discussion. The discovery of new proteins and gene muta...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360802335716
更新日期：2008-01-01 00:00:00
abstract：:Cancer is a major and increasing public health problem worldwide. Traditionally, the diagnosis and staging of cancer, as well as the evaluation of response to therapy have been primarily based on morphology, with relatively few cancer biomarkers currently in use. Conventional biomarker studies have been focused on sin...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360600922632
更新日期：2006-01-01 00:00:00
abstract：:Natural polyphenols are secondary metabolites of plants involved in defense against different types of stress. Extracts containing these compounds have been used for thousands of years in traditional eastern medicine. Polyphenols act on multiple targets in pathways and mechanisms related to carcinogenesis, tumor cell ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2011.631268
更新日期：2011-09-01 00:00:00
abstract：:The presence of circulating tumor cells (CTCs) in peripheral blood can serve as a "liquid biopsy" approach and has thus emerged lately as one of the hottest fields in cancer research. CTCs can be isolated from blood in a non-invasive approach, and can be used to follow patients over time since these cells can provide ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2014.896316
更新日期：2014-06-01 00:00:00
abstract：:Reviewed are the phosphorylation events reporting activation of protein kinases and the key substrates critical for the DNA damage signaling (DDS). These DDS events are detected immunocytochemically using phospho-specific Abs; flow cytometry or image-assisted cytometry provide the means to quantitatively assess them o...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2012.738808
更新日期：2012-09-01 00:00:00
abstract：:Despite great progress in prevention strategies, pharmacotherapy and interventional treatment of coronary artery disease (CAD), cardiovascular events still constitute the leading cause of mortality and morbidity in the modern world. Traditional risk factors, including hypertension, diabetes mellitus, smoking, obesity,...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2014.913549
更新日期：2014-10-01 00:00:00
abstract：:Urine drug testing is one of the objective tools available to assess adherence. To monitor adherence, quantitative urinary results can assist in differentiating "new" drug use from "previous" (historical) drug use. "Spikes" in urinary concentration can assist in identifying patterns of drug use. Coupled chromatographi...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.1080/10408363.2020.1774493
更新日期：2020-12-01 00:00:00
abstract：:Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection, and it probably represents a pattern of response by the immune system to injury. A hyper-inflammatory response is followed by an immunosuppressive phase during which multiple organ dysfunction is present and the patient is sus...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2013.764490
更新日期：2013-01-01 00:00:00
abstract：:The problems of assessment of human zinc status are reviewed, with particular emphasis on the limitations to each of the current available measurements. The advantages and limitations of leukocytes are then described. Methods of preparation and potential problems in the assay for zinc are described in detail. The data...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.3109/10408368409165771
更新日期：1984-01-01 00:00:00
abstract：:The CK-BB isoenzyme is ubiquitous in neoplastic tissue, but with low activity. Accordingly, it might be a nonspecific and insensitive tumor marker. Evaluation of BB isoenzyme in serum might indicate the extent of diseases or the response to therapy. The presence of CK-MB in patients with cancers may cause confusion wi...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368609165795
更新日期：1986-01-01 00:00:00
abstract：:von Willebrand factor (VWF) is a multimeric plasma protein that mediates platelet adhesion as well as platelet aggregation at sites of vascular injury and acts as a carrier of factor VIII. Although acquired or inherited VWF deficiency is associated with a bleeding tendency, there is increasing evidence that VWF has a ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360600966753
更新日期：2007-01-01 00:00:00
abstract：:Hypophosphatasia is a rare inherited disorder in which the activity of the bone/liver/kidney or tissue nonspecific form of alkaline phosphatase (ALP) is reduced. The clinical expression of the disease is highly variable, but in early life the severity tends to reflect the age of onset. Accordingly, the disease is ofte...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408369109106862
更新日期：1991-01-01 00:00:00
abstract：:Crohn's disease (CD) and ulcerative colitis (UC) are the two principal forms of inflammatory bowel disease (IBD). Animal studies show that bacteria are involved in the etiology of IBD, and much is now known about the inflammatory processes associated with CD and UC, as well as the underlying genetic, environmental, an...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360802485792
更新日期：2009-01-01 00:00:00
abstract：:This review provides specific information concerning the interpretation and usefulness of antidepressant drug monitoring. Fifteen antidepressants (ADs) were selected based on their importance in the 7 major markets (Japan, USA, France, United Kingdom, Italy, Spain, Germany) according to the Cognos Plus Study #11. Lite...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360701713112
更新日期：2008-01-01 00:00:00
abstract：:A wide range of protein cancer biomarkers is currently recommended in international guidelines for monitoring the growth and regression of solid tumors. However, a number of these markers are also present in low concentrations in blood obtained from healthy individuals and from patients with benign diseases. In contra...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2014.893279
更新日期：2014-06-01 00:00:00
abstract：:Our understanding of risk factors for atherogenesis has changed significantly over the last decade. In addition to better grasp of the mechanism of action of the "classic" (causal) risk factors, a number of potentially important new factors has emerged. In this review we briefly summarize the evidence of the relation ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/20014091084245
更新日期：2001-10-01 00:00:00
abstract：:Prostate cancer (PCa) is one of the most common age-related cancers among men. Various environmental and genetic factors are involved in the development and progression of PCa. In most cases, the primary symptoms of disease are not severe. Therefore, it is common for patients to be referred with severe clinical manife...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.1080/10408363.2019.1657061
更新日期：2020-01-01 00:00:00
abstract：:Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408363.2017.1414142
更新日期：2018-01-01 00:00:00
abstract：:The genes of the human leukocyte antigen (HLA) region, the major histocompatibility complex (MHC) of humans, control a variety of functions involved in immune response and influence susceptibility to over 40 diseases. Theoretical studies in the development of models to determine the modes of inheritance of the HLA-ass...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408369509084684
更新日期：1995-01-01 00:00:00
abstract：:Despite the ever growing collection of data concerning the function of the immune system in patients with epidermoid carcinoma of the head and neck, the precise mechanism by which these tumors effect the body's surveillance against foreign antigen is as yet unidentified. If these specific immunological characteristics...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368309165758
更新日期：1983-01-01 00:00:00
abstract：:Regarding the widespread progression of diabetes, its related complications and detrimental effects on human health, investigations on this subject seems compulsory. AMP-activated protein kinase (AMPK) is a serine/threonine kinase and a key player in energy metabolism regulation. AMPK is also considered as a prime tar...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408363.2019.1648376
更新日期：2019-11-01 00:00:00
abstract：:Hypersensitivity pneumonitis (HP) is a group of immunologically mediated lung diseases caused by the inhalation of environmental agents in susceptible individuals. Most HP patients are non-smokers and have been exposed to organic dusts from vegetable or animal products. Some HP cases are associated with exposures to r...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360290795583
更新日期：2002-11-01 00:00:00
abstract：:The coupling of hematologic data with radionuclide studies of the spleen has provided information as to the functioning of the organ in a variety of disease states. The major radionuclide studies have been presented in terms of the type of information derivable and the various conditions that can result in fairly simi...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368909105717
更新日期：1989-01-01 00:00:00
abstract：:The constrained economic context leads laboratories to centralize their routine analyses on high-throughput platforms, to which blood collection tubes are sent from peripheral sampling sites that are sometimes distantly located. Providing biochemistry results as quickly as possible implies to consolidate the maximum n...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408363.2018.1499708
更新日期：2018-11-01 00:00:00
