Abstract:
:The prevalence of secondary hypertension can be underestimated if appropriate tests are not performed. The importance of selecting patients with a high pre-test probability of secondary forms of hypertension is first discussed. The laboratory tests currently used for seeking a cause of hypertension are critically reviewed, with emphasis on their operative features and limitations. Strategies to identify primary aldosteronism, the most frequent form of secondary hypertension, and to determine its unilateral or bilateral causes are described. Treatment entails adrenalectomy in unilateral forms, and mineralocorticoid receptor blockade in bilateral forms. Renovascular hypertension is also a common, curable form of hypertension, that should be identified as early as possible to avoid the onset of cardiovascular target organ damage. The tests for its confirmation or exclusion are discussed. The various tests available for the diagnosis of pheochromocytoma, which is much rarer than the above but extremely important to identify, are also described, with emphasis on recent developments in genetic testing. Finally, the tests for diagnosing some rarer monogenic forms and other renal and endocrine causes of arterial hypertension are explored.
journal_name
Crit Rev Clin Lab Scijournal_title
Critical reviews in clinical laboratory sciencesauthors
Rossi GP,Seccia TM,Pessina ACdoi
10.1080/10408360600931831subject
Has Abstractpub_date
2007-01-01 00:00:00pages
1-85issue
1eissn
1040-8363issn
1549-781Xpii
N6861165202530K3journal_volume
44pub_type
杂志文章,评审abstract::The CK-BB isoenzyme is ubiquitous in neoplastic tissue, but with low activity. Accordingly, it might be a nonspecific and insensitive tumor marker. Evaluation of BB isoenzyme in serum might indicate the extent of diseases or the response to therapy. The presence of CK-MB in patients with cancers may cause confusion wi...
journal_title:Critical reviews in clinical laboratory sciences
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doi:10.3109/10408368609165795
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abstract::The science of blood rheology (study of the flow and deformability of blood) is of increasing practical importance to the investigation of blood disorders. In diagnostic laboratories, rheological tests such as the erythrocyte sedimentation rate, zeta sedimentation ratio, and plasma viscosity are used to monitor patien...
journal_title:Critical reviews in clinical laboratory sciences
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abstract::The presence of circulating tumor cells (CTCs) in peripheral blood can serve as a "liquid biopsy" approach and has thus emerged lately as one of the hottest fields in cancer research. CTCs can be isolated from blood in a non-invasive approach, and can be used to follow patients over time since these cells can provide ...
journal_title:Critical reviews in clinical laboratory sciences
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abstract::The red blood cell distribution width (RDW) is a simple and inexpensive parameter, which reflects the degree of heterogeneity of erythrocyte volume (conventionally known as anisocytosis), and is traditionally used in laboratory hematology for differential diagnosis of anemias. Nonetheless, recent evidence attests that...
journal_title:Critical reviews in clinical laboratory sciences
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abstract::Urinary nucleosides offer a number of useful laboratory and clinical applications in the study and analysis of leukemia. There are significant differences in the excretion of modified nucleosides between normal individuals and individuals with various forms of leukemia, as well as between leukemia patients at opposite...
journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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abstract::Urine drug testing is one of the objective tools available to assess adherence. To monitor adherence, quantitative urinary results can assist in differentiating "new" drug use from "previous" (historical) drug use. "Spikes" in urinary concentration can assist in identifying patterns of drug use. Coupled chromatographi...
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
pub_type: 杂志文章,评审
doi:10.3109/10408368109106453
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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abstract::The physical properties and chemical composition of urine are highly variable and are determined in large measure by the quantity and the type of food consumed. The specific gravity is the ratio of the density to that of water, and it is dependent on the number and weight of solute particles and on the temperature of ...
journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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journal_title:Critical reviews in clinical laboratory sciences
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