Abstract：
:There have been numerous reports of spectrophotometric and volume problems caused by elevated levels of lipids in blood. The offending lipids, primarily triglycerides, not only cause turbidity leading to optical aberrations when added to analytical reagents, but also result in short-sampling errors leading to the measurement of inaccurate volumes of sample. Numerous methods have been developed to clear the lipemia, including ultracentrifugation organic solvent extraction, chemical precipitation and, most recently, enzymic hydrolysis. Although the latter procedures eliminate the optical problems, they do not deal with the volume dilution error created by the triglycerides. In turn, corrective mathematics have been developed to compensate for the inaccurate pipetting caused by the elevated lipids in a sample; however, these empirical calculations are not truly accurate at high concentrations of total lipids. This monograph will describe the problems caused by the presence of elevated lipids and the means available for treating them.
journal_name
Crit Rev Clin Lab Scijournal_title
Critical reviews in clinical laboratory sciencesauthors
Artiss JD,Zak Bdoi
10.3109/10408368709105876subject
Has Abstractpub_date
1987-01-01 00:00:00pages
19-41issue
1eissn
1040-8363issn
1549-781Xjournal_volume
25pub_type
杂志文章,评审abstract：:Homologous blood transfusion has been implicated as a modulator of the host immune system in a number of clinical settings. Improved renal allograft survival is observed in patients receiving pretransplant transfusions. Decreased recurrence of active inflammatory bowel disease has been recently reported in transfused ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408369009105899
更新日期：1990-01-01 00:00:00
abstract：:Hypersensitivity pneumonitis (HP) is a group of immunologically mediated lung diseases caused by the inhalation of environmental agents in susceptible individuals. Most HP patients are non-smokers and have been exposed to organic dusts from vegetable or animal products. Some HP cases are associated with exposures to r...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360290795583
更新日期：2002-11-01 00:00:00
abstract：:Acute leukemias (ALs) are often associated with chromosomal translocations, in particular, KMT2A/MLL gene rearrangements. Identification or confirmation of these translocations is carried out by a number of genetic and molecular methods, some of which are routinely used in clinical practice, while others are primarily...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.1080/10408363.2020.1844135
更新日期：2020-11-18 00:00:00
abstract：:Despite great progress in prevention strategies, pharmacotherapy and interventional treatment of coronary artery disease (CAD), cardiovascular events still constitute the leading cause of mortality and morbidity in the modern world. Traditional risk factors, including hypertension, diabetes mellitus, smoking, obesity,...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2014.913549
更新日期：2014-10-01 00:00:00
abstract：:Most clinical chemical analytes vary in a random manner around a homeostatic set point. Replicate analyses of a series of specimens collected from a group of subjects allows estimation of analytical, within and between subject components of variation. The preferred experimental procedures and statistical methods for e...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368909106595
更新日期：1989-01-01 00:00:00
abstract：:Cancer is a major and increasing public health problem worldwide. Traditionally, the diagnosis and staging of cancer, as well as the evaluation of response to therapy have been primarily based on morphology, with relatively few cancer biomarkers currently in use. Conventional biomarker studies have been focused on sin...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360600922632
更新日期：2006-01-01 00:00:00
abstract：:There have been major advances in our understanding of thrombosis and antithrombotic drugs. This review focuses on the molecular aspects of thrombus formation and antithrombotic therapy. Molecules involved in arterial thrombosis are derived from inflammatory cells in the atherosclerotic plaque and blood platelets. The...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360590951171
更新日期：2005-01-01 00:00:00
abstract：:The physical properties and chemical composition of urine are highly variable and are determined in large measure by the quantity and the type of food consumed. The specific gravity is the ratio of the density to that of water, and it is dependent on the number and weight of solute particles and on the temperature of ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368809105890
更新日期：1988-01-01 00:00:00
abstract：:Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection, and it probably represents a pattern of response by the immune system to injury. A hyper-inflammatory response is followed by an immunosuppressive phase during which multiple organ dysfunction is present and the patient is sus...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2013.764490
更新日期：2013-01-01 00:00:00
abstract：:Maximum stability of analytes in chemistry control materials is desired. Stability testing is customarily performed by manufacturers, both prior to distribution of products and during the period following distribution when the products are in the field. Users and evaluators of such materials periodically have reported...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368209107031
更新日期：1982-01-01 00:00:00
abstract：:Natural polyphenols are secondary metabolites of plants involved in defense against different types of stress. Extracts containing these compounds have been used for thousands of years in traditional eastern medicine. Polyphenols act on multiple targets in pathways and mechanisms related to carcinogenesis, tumor cell ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2011.631268
更新日期：2011-09-01 00:00:00
abstract：:Hemophilia care depends on several factors for the production of purified FVIII: plasma procurement, plasma logistics, production method, and efficacy. The latter two are restrictive factors, both for the supply and the safety of FVIII preparations. Conventional production methodology unavoidably recovers only 10 to 2...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368609111596
更新日期：1986-01-01 00:00:00
abstract：:The red blood cell distribution width (RDW) is a simple and inexpensive parameter, which reflects the degree of heterogeneity of erythrocyte volume (conventionally known as anisocytosis), and is traditionally used in laboratory hematology for differential diagnosis of anemias. Nonetheless, recent evidence attests that...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2014.992064
更新日期：2015-01-01 00:00:00
abstract：:Regarding the widespread progression of diabetes, its related complications and detrimental effects on human health, investigations on this subject seems compulsory. AMP-activated protein kinase (AMPK) is a serine/threonine kinase and a key player in energy metabolism regulation. AMPK is also considered as a prime tar...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408363.2019.1648376
更新日期：2019-11-01 00:00:00
abstract：:Prostate cancer (PCa) is one of the most common age-related cancers among men. Various environmental and genetic factors are involved in the development and progression of PCa. In most cases, the primary symptoms of disease are not severe. Therefore, it is common for patients to be referred with severe clinical manife...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.1080/10408363.2019.1657061
更新日期：2020-01-01 00:00:00
abstract：:Isoforms of the receptor for advanced glycation end-product (RAGE) protein, which lack the transmembrane and the signaling (soluble RAGE or sRAGE) domains are hypothesized to counteract the detrimental action of the full-length receptor by acting as a decoy, and they provide a potential tool to treat RAGE-associated d...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.1080/10408363.2020.1791045
更新日期：2020-07-15 00:00:00
abstract：:Microcytic red blood cell states are common clinical problems in both adult and pediatric age groups. The recent widespread availability of electronic blood cell counters for performing routine blood counts has increased the detection of microcytic red blood cells. Physicians must workup both symptomatic and asymptoma...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368209107028
更新日期：1982-01-01 00:00:00
abstract：:The discovery of a G protein-coupled, calcium-sensing receptor (CaR) a decade ago and of diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical role in the maintenance of systemic calcium homeostasis. On the cell membrane of the chief cells of the parathyroid glands, the CaR "senses" t...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360590886606
更新日期：2005-01-01 00:00:00
abstract：:Oncogenes and tumor suppressor genes are genes involved in cell proliferation and differentiation. They play a crucial role in the initiation and progression of cancer. Some of these genes are found to be altered in human cancers, i.e., mutated, amplified, deleted, translocated, or abnormally regulated. Recently, the ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408369209114603
更新日期：1992-01-01 00:00:00
abstract：:Despite the ever growing collection of data concerning the function of the immune system in patients with epidermoid carcinoma of the head and neck, the precise mechanism by which these tumors effect the body's surveillance against foreign antigen is as yet unidentified. If these specific immunological characteristics...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368309165758
更新日期：1983-01-01 00:00:00
abstract：:Serum gamma-glutamyl transferase (GGT) has been widely used as an index of liver dysfunction and marker of alcohol intake. The last few years have seen improvements in these areas and advances in understanding of its physiological role in counteracting oxidative stress by breaking down extracellular glutathione and ma...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/20014091084227
更新日期：2001-08-01 00:00:00
abstract：:Bartter's and Gitelman's syndromes can be used as models to gain insight into the mechanisms responsible for maintaining/controlling vascular tone. In fact, the study of patients with these syndromes provides important insights into mechanistic details of the most relevant pathways of vascular tone. So far, several ex...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360091174295
更新日期：2000-12-01 00:00:00
abstract：:The substrate spectrum of human UDP-glucuronosyltransferase 1A (UGT1A) proteins includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants, chemotherapeutics, steroid hormones, bile acids, and bilirubin. The unique genetic organization of the human UGT1A gene locus, and an increasing number...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360802374624
更新日期：2008-01-01 00:00:00
abstract：:The aim of this review is to summarize present evidence of an association between circulating levels of C-reactive protein (CRP) and cancer risk, and to evaluate whether elevated circulating CRP levels cause cancer. Additionally, the review provides background information on the acute-phase response, chronic inflammat...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2011.599831
更新日期：2011-07-01 00:00:00
abstract：:Vitamin D has been attributed roles in the pathogenesis and prevention of several diseases such as cancer, cardiovascular disease, multiple sclerosis, diabetes, autism and autoimmune diseases. The concomitant expression of the 25-hydroxyvitamin D3-1α-hydroxylase and of the vitamin D3 receptor in animal and human tissu...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408363.2014.901291
更新日期：2014-08-01 00:00:00
abstract：:Estrone sulfate (E1S) is the most abundant circulating estrogen and it has the potential to be used as a biomarker in certain conditions where estimation of low levels of estrogen or changes in relative levels of estrogens are important. This review will critically consider the role of estimating E1S for clinical labo...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408363.2016.1252310
更新日期：2017-03-01 00:00:00
abstract：:Urine drug testing is one of the objective tools available to assess adherence. To monitor adherence, quantitative urinary results can assist in differentiating "new" drug use from "previous" (historical) drug use. "Spikes" in urinary concentration can assist in identifying patterns of drug use. Coupled chromatographi...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.1080/10408363.2020.1774493
更新日期：2020-12-01 00:00:00
abstract：:Muscle wasting in patients with sepsis, severe injury, and cancer is associated with increased transcription of several genes regulating different proteolytic pathways. The involvement of gene activation in muscle wasting suggests that transcription factors and nuclear cofactors play important roles in the regulation ...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章
doi：10.3109/10408363.2011.591365
更新日期：2011-03-01 00:00:00
abstract：:The CK-BB isoenzyme is ubiquitous in neoplastic tissue, but with low activity. Accordingly, it might be a nonspecific and insensitive tumor marker. Evaluation of BB isoenzyme in serum might indicate the extent of diseases or the response to therapy. The presence of CK-MB in patients with cancers may cause confusion wi...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.3109/10408368609165795
更新日期：1986-01-01 00:00:00
abstract：:Low molecular-mass plasma proteins play a key role in health and disease. Cystatin C is an endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a mole...
journal_title：Critical reviews in clinical laboratory sciences
pub_type： 杂志文章,评审
doi：10.1080/10408360490504934
更新日期：2004-01-01 00:00:00
