Microarray technology: a promising tool in nutrigenomics.

Abstract:

:Microarray technology is a powerful tool for the global evaluation of gene expression profiles in tissues and for understanding many of the factors controlling the regulation of gene transcription. This technique not only provides a considerable amount of information on markers and predictive factors that may potentially characterize a specific clinical picture, but also promises new applications for therapy. One of the most recent applications of microarrays concerns nutritional genomics. Nutritional genomics, known as nutrigenomics, aims to identify and understand mechanisms of molecular interaction between nutrients and/or other dietary bioactive compounds and the genome. Actually, many nutrigenomic studies utilize new approaches such as microarrays, genomics, and bioinformatics to understand how nutrients influence gene expression. The coupling of these new technologies with nutrigenomics promises to lead to improvements in diet and health. In fact, it may provide new information which can be used to ameliorate dietary regimens and to discover novel natural agents for the treatment of important diseases such as diabetes and cancer. This critical review gives an overview of the clinical relevance of a nutritional approach to several important diseases, and proposes the use of microarray for nutrigenomic studies.

journal_name

Crit Rev Food Sci Nutr

authors

Masotti A,Da Sacco L,Bottazzo GF,Alisi A

doi

10.1080/10408390903044156

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

693-8

issue

7

eissn

1040-8398

issn

1549-7852

pii

925281684

journal_volume

50

pub_type

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