Past and Present Insights on Alpha-linolenic Acid and the Omega-3 Fatty Acid Family.

Abstract:

:Alpha-linolenic acid (ALA) is the parent essential fatty acid of the omega-3 family. This family includes docosahexaenoic acid (DHA), which has been conserved in neural signaling systems in the cephalopods, fish, amphibian, reptiles, birds, mammals, primates, and humans. This extreme conservation, in spite of wide genomic changes of over 500 million years, testifies to the uniqueness of this molecule in the brain and affirms the importance of omega-3 fatty acids. While DHA and its close precursor, eicosapentaenoic acids (EPA), have received much attention by the research community, ALA, as the precursor of both, has been considered of little interest. There are many papers on ALA requirements in experimental animals. Unlike humans, rats and mice can readily convert ALA to EPA and DHA, so it is unclear whether the effect is solely due to the conversion products or to ALA itself. The intrinsic role of ALA has yet to be defined. This paper will discuss both recent and historical findings related to this distinctive group of fatty acids, and will highlight the physiological significance of the omega-3 family.

journal_name

Crit Rev Food Sci Nutr

authors

Stark AH,Reifen R,Crawford MA

doi

10.1080/10408398.2013.828678

subject

Has Abstract

pub_date

2016-10-25 00:00:00

pages

2261-7

issue

14

eissn

1040-8398

issn

1549-7852

journal_volume

56

pub_type

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