Procyanidins improve some disrupted glucose homoeostatic situations: an analysis of doses and treatments according to different animal models.

Abstract:

:This review analyses the potential beneficial effects of procyanidins, the main class of flavonoids, in situations in which glucose homeostasis is disrupted. Because the disruption of glucose homeostasis can occur as a result of various causes, we critically review the effects of procyanidins based on the specific origin of each type of disruption. Where little or no insulin is present (Type I diabetic animals), summarized studies of procyanidin treatment suggest that procyanidins have a short-lived insulin-mimetic effect on the internal targets of the organism, an effect not reproduced in normoglycemic, normoinsulinemic healthy animals. Insulin resistance (usually linked to hyperinsulinemia) poses a very different situation. Preventive studies using fructose-fed models indicate that procyanidins may be useful in preventing the induction of damage and thus in limiting hyperglycemia. But the results of other studies using models such as high-fat diet treated rats or genetically obese animals are controversial. Although the effects on glucose parameters are hazy, it is known that procyanidins target key tissues involved in its homeostasis. Interestingly, all available data suggest that procyanidins are more effective when administered in one acute load than when mixed with food.

journal_name

Crit Rev Food Sci Nutr

authors

Pinent M,Cedó L,Montagut G,Blay M,Ardévol A

doi

10.1080/10408398.2010.501533

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

569-84

issue

7

eissn

1040-8398

issn

1549-7852

journal_volume

52

pub_type

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