Abstract：
:We previously constructed an arabinose-inducible recombinant Bifidobacterium longum that could efficiently express secreted IFN-alpha2b in vitro (Deng et al. in Arch Microbiol 191:681-686, 2009). Here, we investigated the influence of oral pBAD-SPIFN-transformed B. longum on immunomodulation and IFN-induced Mx1 gene transcription in mice. We observed enhanced serum and fecal IFN-alpha2b concentrations in mice orally administered recombinant B. longum, suggesting a possible Th1 pattern of induction in the spleen and Peyer's patches. Transcription of the typically IFN-induced antiviral Mx1 gene in the hepatic and intestinal tissues of these mice was also markedly enhanced. In conclusion, oral administration of the recombinant B. longum expressing IFN-alpha2b might play its roles in the immunomodulation of the mice, and the potential clinical value of this bacterium in the treatment of viral infections needs to be further studied.
journal_name
Arch Microbioljournal_title
Archives of microbiologyauthors
Yu Z,Zeng Z,Huang Z,Lian J,Yang J,Deng Q,Zeng Wdoi
10.1007/s00203-010-0589-1subject
Has Abstractpub_date
2010-08-01 00:00:00pages
633-8issue
8eissn
0302-8933issn
1432-072Xjournal_volume
192pub_type
杂志文章abstract：:Exoglucanase (exo-1,3-beta-D-glucan glycohydrolase, EC 3.2.1.56) activity secreted by Saccharomyces cerevisiae into the culture medium was separated by ion exchange chromatography into two glycoprotein isoenzymes which contributed 10% (exoglucanase I) and 90% (exoglucanase II) towards the total activity. Analysis of t...
journal_title：Archives of microbiology
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journal_title：Archives of microbiology
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更新日期：2015-06-01 00:00:00
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更新日期：2005-08-01 00:00:00
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更新日期：2008-01-01 00:00:00
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更新日期：2010-07-01 00:00:00
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更新日期：2002-04-01 00:00:00
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更新日期：2015-03-01 00:00:00
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更新日期：2004-01-01 00:00:00
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更新日期：2011-07-01 00:00:00
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journal_title：Archives of microbiology
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更新日期：2010-10-01 00:00:00
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journal_title：Archives of microbiology
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更新日期：2014-12-01 00:00:00
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journal_title：Archives of microbiology
pub_type： 杂志文章
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更新日期：1999-01-01 00:00:00
