ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages.

abstract：BACKGROUND:Dendritic cells (DC) play the key role in directing antigen-specific immune responses and manipulating their function may be a useful tool for immunotherapy. The balance between immune stimulation and tolerance is particularly important at mucosal interfaces, where discrimination between dangerous pathogens ...

journal_title：BMC immunology

authors： Polak ME,Borthwick NJ,Gabriel FG,Jager MJ,Cree IA

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG > 1.3 μg/mL an...

journal_title：BMC immunology

authors： Parker AR,Skold M,Harding S,Barton JC,Bertoli LF,Barton JC

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Tuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients wit...

journal_title：BMC immunology

authors： Qama D,Choi WI,Kwon KY

更新日期：2012-08-13 00:00:00

abstract：BACKGROUND:Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on the myelo-depletive effects of certain chemotherapy agents. We have shown previously that decitabine ...

journal_title：BMC immunology

authors： Luker AJ,Graham LJ,Smith TM Jr,Camarena C,Zellner MP,Gilmer JS,Damle SR,Conrad DH,Bear HD,Martin RK

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:Activation signals can be negatively regulated by cell surface receptors bearing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD300a, an ITIM bearing type I transmembrane protein, is expressed on many hematopoietic cells, including subsets of lymphocytes. RESULTS:We have taken two approaches to ...

journal_title：BMC immunology

authors： DeBell KE,Simhadri VR,Mariano JL,Borrego F

更新日期：2012-04-26 00:00:00

abstract：BACKGROUND:Impaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate the ROS and inflammatory cytokines during the inflammatory phase (first day) in streptozotocin (STZ...

journal_title：BMC immunology

authors： Ebaid H,Ahmed OM,Mahmoud AM,Ahmed RR

更新日期：2013-07-25 00:00:00

abstract：BACKGROUND:Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant activation of T cells and excessive release of pro-inflammatory cytokines ultimately resulting in cap...

journal_title：BMC immunology

authors： Kim H,Darwish I,Monroy MF,Prockop DJ,Liles WC,Kain KC

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:Most in vivo studies that have addressed the role of actin dynamics in NADPH oxidase function in phagocytes have used toxins to modulate the polymerization state of actin and mostly effects on actin has been evaluated by end point measurements of filamentous actin, which says little about actin dynamics, and...

journal_title：BMC immunology

authors： Rasmussen I,Pedersen LH,Byg L,Suzuki K,Sumimoto H,Vilhardt F

更新日期：2010-09-08 00:00:00

abstract：BACKGROUND:Vascular calcification is often associated with chronic inflammation and is a risk factor for brain arterial stiffness. Our previous results showed that miR32-5p was positively correlated with vascular smooth muscle cells (VSMC) calcification, but it is unclear whether miR32-5p promoted VSMC calcification by...

journal_title：BMC immunology

authors： Cao J,Chen L,Zhong X,Shen Y,Gao Y,Chen Q,Zu X,Liu J

更新日期：2020-01-17 00:00:00

abstract：BACKGROUND:Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as therapeutic agent requires further investigation. RESULTS:Here, we showed that plasmid DNA (pcDNA3) at low doses inhibits the production of IL-6 and TNF-α ...

journal_title：BMC immunology

authors： Malardo T,Batalhão ME,Panunto-Castelo A,Almeida LP,Padilha E,Fontoura IC,Silva CL,Carnio EC,Coelho-Castelo AA

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are important immune cell surface mar...

journal_title：BMC immunology

authors： Huggard D,McGrane F,Lagan N,Roche E,Balfe J,Leahy TR,Franklin O,Moreno A,Melo AM,Doherty DG,Molloy EJ

更新日期：2018-11-03 00:00:00

abstract：BACKGROUND:Macrophages are key players in the initiation, perpetuation and regulation of both innate and adaptive immune responses. They largely perform these roles through modulation of the expression of genes, especially those encoding cytokines. Murine bone marrow derived macrophages (BMDMs) are commonly used as a m...

journal_title：BMC immunology

authors： Tanaka A,To J,O'Brien B,Donnelly S,Lund M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS:We isolated peripheral blood mononuclear cells from children...

journal_title：BMC immunology

authors： Jia L,Wang Y,Li J,Li S,Zhang Y,Shen J,Tan W,Wu C

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Cryopreservation of peripheral blood mononuclear cells has been used to preserve and standardize immunologic measurements for multicenter studies, however, effects of cryopreservation on cytokine responses are incompletely understood. In designing immunologic studies for a new multicenter birth cohort study ...

journal_title：BMC immunology

authors： Shreffler WG,Visness CM,Burger M,Cruikshank WW,Lederman HM,de la Morena M,Grindle K,Calatroni A,Sampson HA,Gern JE

更新日期：2006-12-12 00:00:00

abstract：BACKGROUND:We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Here, we have demonstrated th...

journal_title：BMC immunology

authors： Dawson HD,Collins G,Pyle R,Key M,Taub DD

更新日期：2008-04-16 00:00:00

abstract：BACKGROUND:It has been recognized that phospholipase A2 (PLA2) is a crucial component of snake venom, which contributes greatly to snake venom induced inflammation in man. However, the mechanisms through which N49 PLA2 provoke inflammation remain unclear. Recently, a N49 PLA2, TM-N49 from Protobothrops mucrosquamatus c...

journal_title：BMC immunology

authors： Wei JF,Wei XL,Mo YZ,He SH

更新日期：2009-04-28 00:00:00

abstract：BACKGROUND:Human tonsils are a rich source of B lymphocytes exhibiting a variety of phenotypes and activation states. Existing methods of purification are time consuming or costly. The aim of the present study was to optimize conditions to isolate large numbers of highly purified primary B lymphocytes from tonsils in a...

journal_title：BMC immunology

authors： Zuccolo J,Unruh TL,Deans JP

更新日期：2009-05-27 00:00:00

abstract：BACKGROUND:Parasite-specific IgE levels correlate with human resistance to reinfection with Schistosoma spp. after chemotherapy. Although the role of eosinophils in schistosomiasis has been the focus of a great deal of important research, the involvement of other Fcepsilon receptor-bearing cells, such as mast cells and...

journal_title：BMC immunology

authors： Satti MZ,Cahen P,Skov PS,Joseph S,Jones FM,Fitzsimmons C,Hoffmann KF,Reimert C,Kariuki HC,Kazibwe F,Mwatha JK,Kimani G,Vennervald BJ,Ouma JH,Kabatereine NB,Dunne DW

更新日期：2004-04-21 00:00:00

abstract：BACKGROUND:Dysregulation of the immune system has been shown to occur during spaceflight, although the detailed nature of the phenomenon and the clinical risks for exploration class missions have yet to be established. Also, the growing clinical significance of immune system evaluation combined with epidemic infectious...

journal_title：BMC immunology

authors： Crucian B,Lee P,Stowe R,Jones J,Effenhauser R,Widen R,Sams C

更新日期：2007-05-23 00:00:00

abstract：BACKGROUND:The purpose of this study was to characterize specific cytotoxic T-cell (CTL) responses in men who have sex with men (MSM) subjects infected with the human immunodeficiency virus type 1 (HIV-1) CRF01_AE subtype during the first year of infection and impacts on viral control and evolution. RESULTS:Fifteen HI...

journal_title：BMC immunology

authors： Jiang F,Han X,Zhang H,Zhao B,An M,Xu J,Chu Z,Dong T,Shang H

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:To understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region from DBA/1(-/-) mice that are resistant to spontaneous arthritis into BALB...

journal_title：BMC immunology

authors： Deng N,Jiao Y,Cao Y,Liu X,Ma Y,Hasty KA,Brand DD,Stuart JM,Gu W

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology...

journal_title：BMC immunology

authors： Lohrberg M,Pabst R,Wilting J

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Non-adherence has been associated with reduced graft survival. The aim of this study was to investigate the immunological mechanisms underlying chronic renal allograft rejection using a model of non-adherence to immunosuppressive therapy. We used a MHC (major histocompatibility complex) -mismatched rat model...

journal_title：BMC immunology

authors： Kühne L,Jung B,Poth H,Schuster A,Wurm S,Ruemmele P,Banas B,Bergler T

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by the novel coronavirus SARS-CoV. The T cell epitopes of the SARS CoV spike protein are well known, but no systematic evaluation of the functional and structural roles of each residue has been reported for these antigenic epit...

journal_title：BMC immunology

authors： Huang J,Cao Y,Bu X,Wu C

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Active cancer immunotherapies are beginning to yield clinical benefit, especially those using peptide-pulsed dendritic cells (DCs). Different adjuvants, including Toll-like receptor (TLR) agonists, commonly co-administered to cancer patients as part of a DC-based vaccine, are being widely tested in the clini...

journal_title：BMC immunology

authors： Ioannou K,Derhovanessian E,Tsakiri E,Samara P,Kalbacher H,Voelter W,Trougakos IP,Pawelec G,Tsitsilonis OE

更新日期：2013-09-22 00:00:00

abstract：AIM:Brucellar spondylitis (BS) is one of the most serious complications of brucellosis. CXCR3 is closely related to the severity of disease infection. This research aimed to study the degree of BS inflammatory damage through analyzing the expression levels of CXCR3 and its ligands (CXCL9 and CXCL10) in patients with BS...

journal_title：BMC immunology

authors： Hu X,Shang X,Wang L,Fan J,Wang Y,Lv J,Nazierhan S,Wang H,Wang J,Ma X

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:Interleukin 7 (IL-7) signals via the IL-7 receptor (IL-7R) and drives homeostatic T-cell proliferation in patients after allogeneic hematopoietic stem cell transplantation (aHSCT). PURPOSE:We performed a prospective study in adults (n = 33) and children (n = 29) undergoing aHSCT measuring plasma IL-7 and so...

journal_title：BMC immunology

authors： Poiret T,Rane L,Remberger M,Omazic B,Gustafsson-Jernberg A,Vudattu NK,Ahmed R,Ernberg I,Winiarski J,Magalhaes I,Ringden O,Maeurer M

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:T-cells extravasation and CNS parenchyma infiltration during autoimmune neurodegenerative disease can be evoked by local antigen presenting cells. Studying the chemoattracting potential of spinal perivascular macrophages (SPM) during experimental allergic encephalomyelitis (EAE), we observed numerous infiltr...

journal_title：BMC immunology

authors： Hofmann N,Lachnit N,Streppel M,Witter B,Neiss WF,Guntinas-Lichius O,Angelov DN

更新日期：2002-08-26 00:00:00

abstract：BACKGROUND:Allergic skin inflammation such as atopic dermatitis (AD), which is characterized by pruritus and inflammation, is regulated partly through the activity of regulatory T cells (Tregs). Tregs play key roles in the immune response by preventing or suppressing the differentiation, proliferation and function of v...

journal_title：BMC immunology

authors： Han SC,Kang GJ,Ko YJ,Kang HK,Moon SW,Ann YS,Yoo ES

更新日期：2012-08-09 00:00:00

abstract：BACKGROUND:In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they can be found deposited extracellularly below the epithelial baseme...

journal_title：BMC immunology

authors： Stenman SM,Lindfors K,Korponay-Szabo IR,Lohi O,Saavalainen P,Partanen J,Haimila K,Wieser H,Mäki M,Kaukinen K

更新日期：2008-02-29 00:00:00