Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia.

abstract：BACKGROUND:Autoimmune lymphoproliferative syndrome (ALPS) is a rare inherited disorder characterized by defective function of Fas, autoimmune manifestations that predominantly involve blood cells, polyclonal accumulation of lymphocytes in the spleen and lymph nodes with lymphoadenomegaly and/or splenomegaly, and expans...

journal_title：BMC immunology

authors： Cerutti E,Campagnoli MF,Ferretti M,Garelli E,Crescenzio N,Rosolen A,Chiocchetti A,Lenardo MJ,Ramenghi U,Dianzani U

更新日期：2007-11-13 00:00:00

abstract：BACKGROUND:Streptococcus pneumoniae is a human pathogenic bacteria and a major cause of severe invasive diseases, including pneumonia, bacteremia, and meningitis. Infections with S. pneumoniae evoke a strong inflammatory response, which plays a major role in the pathogenesis of pneumococcal disease. RESULTS:In this st...

journal_title：BMC immunology

authors： Mogensen TH,Berg RS,Ostergaard L,Paludan SR

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is the causative agent for melioidosis. For many bacterial infections, cytokine dysregulation is one of the contributing factors to the severe clinical outcomes in the susceptible hosts. The C57BL/6 and BALB/c mice have been established as a differential model of susceptibility in m...

journal_title：BMC immunology

authors： Koo GC,Gan YH

更新日期：2006-08-18 00:00:00

abstract：BACKGROUND:The bacterial biofilm at the gingival margin induces a host immune reaction. In this local inflammation epithelial cells defend the host against bacterial challenge. Porphyromonas gingivalis (P. gingivalis), a keystone pathogen, infects epithelial cells. The aim of this study was to investigate the activatio...

journal_title：BMC immunology

authors： Groeger S,Jarzina F,Domann E,Meyle J

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Toll-like receptor 2 (TLR2) plays a critical role in mediating inflammatory/immune responses against bacterial pathogens in lung. Streptococcus pneumoniae (S. pneumoniae) and nontypeable Haemophilus influenzae (NTHi) were previously reported to synergize with each other to induce inflammatory responses. Desp...

journal_title：BMC immunology

authors： Lim JH,Ha U,Sakai A,Woo CH,Kweon SM,Xu H,Li JD

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:Cryopreservation of peripheral blood mononuclear cells (PBMCs) is a common and essential practice in conducting research. There are different reports in the literature as to whether cryopreserved PBMCs need to only be stored ≤ -150 °C or can be stored for a specified time at -80 °C. Therefore, we performed g...

journal_title：BMC immunology

authors： Yang J,Diaz N,Adelsberger J,Zhou X,Stevens R,Rupert A,Metcalf JA,Baseler M,Barbon C,Imamichi T,Lempicki R,Cosentino LM

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Inappropriate responses to normal intestinal bacteria may be involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohn's Disease (CD), Ulcerative Colitis (UC)) and variations in the host genome may mediate this process. IL-10 gene-deficient (Il10-/-) mice develop CD-like colitis mainly in t...

journal_title：BMC immunology

authors： Barnett MP,McNabb WC,Cookson AL,Zhu S,Davy M,Knoch B,Nones K,Hodgkinson AJ,Roy NC

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:The new JAK3 inhibitor, CP690,550, has shown efficacy in the treatment of rheumatoid arthritis. The present study was undertaken to assess the effects of CP690,550 on cytokine production and cellular signaling in human CD4(+) T cells. RESULTS:CD4(+) T cells produced IL-2, IL-4, IL-17, IL-22 and IFN-γ in fol...

journal_title：BMC immunology

authors： Migita K,Miyashita T,Izumi Y,Koga T,Komori A,Maeda Y,Jiuchi Y,Aiba Y,Yamasaki S,Kawakami A,Nakamura M,Ishibashi H

更新日期：2011-08-31 00:00:00

abstract：BACKGROUND:CD33 is a membrane receptor containing a lectin domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) that is able to inhibit cytokine production. CD33 is expressed by monocytes, and reduced expression of CD33 correlates with augmented production of inflammatory cytokines, such as IL...

journal_title：BMC immunology

authors： Gonzalez Y,Herrera MT,Soldevila G,Garcia-Garcia L,Fabián G,Pérez-Armendariz EM,Bobadilla K,Guzmán-Beltrán S,Sada E,Torres M

更新日期：2012-04-14 00:00:00

abstract：BACKGROUND:We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG > 1.3 μg/mL an...

journal_title：BMC immunology

authors： Parker AR,Skold M,Harding S,Barton JC,Bertoli LF,Barton JC

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a large extent determined by the molecular structure accommodating so-called main anchor positions of th...

journal_title：BMC immunology

authors： Sidney J,Peters B,Frahm N,Brander C,Sette A

更新日期：2008-01-22 00:00:00

abstract：BACKGROUND:While vaccination remains the most effective method to control hepatitis B virus (HBV) infection, 5-10% of recipients exhibit non-responsiveness to the HB vaccine. Immunological analysis of strong, weak or absent protective antibody responses to the HB vaccine should provide insights into the mechanisms that...

journal_title：BMC immunology

authors： Xu X,Li Y,Liang Y,Yin M,Yu Z,Zhang Y,Huang L,Ni J

更新日期：2018-07-28 00:00:00

abstract：BACKGROUND:Deer mice (Peromyscus maniculatus) are the most common mammals in North America and are reservoirs for several zoonotic agents, including Sin Nombre virus (SNV), the principal etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in North America. Unlike human HCPS patients, SNV-infected deer mice sh...

journal_title：BMC immunology

authors： Oko L,Aduddell-Swope B,Willis D,Hamor R,Coons TA,Hjelle B,Schountz T

更新日期：2006-08-17 00:00:00

abstract：BACKGROUND:Proinflammatory genes are highly expressed in several metabolic disorders associated with obesity. But it is not clarified whether gene expression levels and downstream inflammatory markers are related to the metabolic state or the presence of obesity. Hence, the present study aimed to compare Toll-Like Rece...

journal_title：BMC immunology

authors： Amiri P,Baradaran B,Saghafi-Asl M,Naghizadeh M,Shanehbandi D,Karamzad N,Vahed SZ

更新日期：2019-07-04 00:00:00

abstract：BACKGROUND:T-cells extravasation and CNS parenchyma infiltration during autoimmune neurodegenerative disease can be evoked by local antigen presenting cells. Studying the chemoattracting potential of spinal perivascular macrophages (SPM) during experimental allergic encephalomyelitis (EAE), we observed numerous infiltr...

journal_title：BMC immunology

authors： Hofmann N,Lachnit N,Streppel M,Witter B,Neiss WF,Guntinas-Lichius O,Angelov DN

更新日期：2002-08-26 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by the novel coronavirus SARS-CoV. The T cell epitopes of the SARS CoV spike protein are well known, but no systematic evaluation of the functional and structural roles of each residue has been reported for these antigenic epit...

journal_title：BMC immunology

authors： Huang J,Cao Y,Bu X,Wu C

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Some chemicals, including some phthalate plasticizers, have been shown to have an adjuvant effect in mice. However, an adjuvant effect, defined as an inherent ability to stimulate the humoral immune response, was only observed after exposure to a limited number of the phthalates. An adjuvant effect may be du...

journal_title：BMC immunology

authors： Larsen ST,Nielsen GD

更新日期：2008-10-31 00:00:00

abstract：BACKGROUND:We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Here, we have demonstrated th...

journal_title：BMC immunology

authors： Dawson HD,Collins G,Pyle R,Key M,Taub DD

更新日期：2008-04-16 00:00:00

abstract：BACKGROUND:It has been recognized that phospholipase A2 (PLA2) is a crucial component of snake venom, which contributes greatly to snake venom induced inflammation in man. However, the mechanisms through which N49 PLA2 provoke inflammation remain unclear. Recently, a N49 PLA2, TM-N49 from Protobothrops mucrosquamatus c...

journal_title：BMC immunology

authors： Wei JF,Wei XL,Mo YZ,He SH

更新日期：2009-04-28 00:00:00

abstract：BACKGROUND:The functional immaturity of T cells contributes to the susceptibility of neonates to infections and the less severe graft-versus-host disease associated with cord blood (CB) transplantation. We have previously reported that insulin-like growth factor - I (IGF-I) promotes the phytohaemagglutinin (PHA)-induce...

journal_title：BMC immunology

authors： Law HK,Tu W,Liu E,Lau YL

更新日期：2008-12-17 00:00:00

abstract：BACKGROUND:Functioning of the immune system requires the coordinated expression and action of many genes and proteins. With the emergence of high-throughput technologies, a great amount of molecular data is available for the genes and proteins of the immune system. However, these data are scattered into several databas...

journal_title：BMC immunology

authors： Ortutay C,Vihinen M

更新日期：2009-01-09 00:00:00

abstract：BACKGROUND:Insulin dependent (i.e., "type 1") diabetes mellitus (T1DM) is considered to be a T cell mediated disease in which TH1 and Tc autoreactive cells attack the pancreatic islets. Among the beta-cell antigens implicated in T1DM, glutamic acid decarboxylase (GAD) 65 appears to play a key role in the development of...

journal_title：BMC immunology

authors： Pedotti R,Sanna M,Tsai M,DeVoss J,Steinman L,McDevitt H,Galli SJ

更新日期：2003-02-22 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS:We isolated peripheral blood mononuclear cells from children...

journal_title：BMC immunology

authors： Jia L,Wang Y,Li J,Li S,Zhang Y,Shen J,Tan W,Wu C

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Pro-inflammatory cytokines can affect intracellular lipid metabolism. A variety of effects have been described for different cell types; hepatocyte lipid turnover pathways are inhibited during inflammation, whereas interleukin-1beta (IL-1beta) reduces intracellular cholesterol levels in fibroblasts. Levels o...

journal_title：BMC immunology

authors： Persson J,Nilsson J,Lindholm MW

更新日期：2008-11-25 00:00:00

abstract：BACKGROUND:Streptococcus sanguinis (S.sanguinis), a predominant bacterium in the human oral cavity, has been widely associated with the development of infective endocarditis. Platelets play both a haemostatic function and can influence both innate and adaptive immune responses. Previous studies have shown that S.sangui...

journal_title：BMC immunology

authors： Cognasse F,Hamzeh-Cognasse H,Chabert A,Jackson E,Arthaud CA,Garraud O,McNicol A

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis and self-tolerance. The immune suppressive effects of Tregs should however be limited in case effective immunity is required against pathogens or cancer cells. We previously found that the Toll-like receptor 2 (TLR2) agonist, Pam...

journal_title：BMC immunology

authors： van Maren WW,Nierkens S,Toonen LW,Bolscher JM,Sutmuller RP,Adema GJ

更新日期：2011-03-24 00:00:00

abstract：BACKGROUND:Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant activation of T cells and excessive release of pro-inflammatory cytokines ultimately resulting in cap...

journal_title：BMC immunology

authors： Kim H,Darwish I,Monroy MF,Prockop DJ,Liles WC,Kain KC

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain ...

journal_title：BMC immunology

authors： Wang C,Yu X,Cao Q,Wang Y,Zheng G,Tan TK,Zhao H,Zhao Y,Wang Y,Harris DCh

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope containing a variety of lipid components that par...

journal_title：BMC immunology

authors： Espinosa-Cueto P,Escalera-Zamudio M,Magallanes-Puebla A,López-Marín LM,Segura-Salinas E,Mancilla R

更新日期：2015-06-23 00:00:00

abstract：BACKGROUND:Impaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate the ROS and inflammatory cytokines during the inflammatory phase (first day) in streptozotocin (STZ...

journal_title：BMC immunology

authors： Ebaid H,Ahmed OM,Mahmoud AM,Ahmed RR

更新日期：2013-07-25 00:00:00