Adiponectin and negative mood in healthy premenopausal and postmenopausal women.

Abstract:

:Negative mood and stress are associated with cardiovascular and metabolic disease. There are likely many physiological mechanisms underlying the poor health outcomes. The relationship of psychological states (negative mood, life stress, and stress-responsive hormones) and adiponectin, an adipokine that promotes insulin sensitivity, was investigated in two separate studies. The two groups of participants included 52 healthy, premenopausal women, and 63 postmenopausal women with a range of stress levels. The relationship between adiponectin and psychological state (perceived stress and negative mood) was examined cross-sectionally in both groups of participants, but also prospectively (1 year later) in the group of postmenopausal women. In premenopausal women, negative mood and nocturnal urinary epinephrine were significantly related to adiponectin, independent of BMI. In postmenopausal women, negative mood was not associated with adiponectin cross-sectionally, but negative mood was a significant predictor for lower levels of adiponectin 1 year later, independent of initial adiponectin concentrations and changes in body mass index. Lastly, having a depressive disorder was related to lower adiponectin. As adiponectin levels are associated with insulin resistance, obesity, and diabetes mellitus, these findings suggest there may be an adiponectin-mediated pathway explaining in part how negative mood affects metabolic health. Mechanistic studies are needed to explore this potential relationship further.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Adam T,Schamarek I,Springer EA,Havel PJ,Epel EE

doi

10.1016/j.yhbeh.2010.05.006

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

699-704

issue

5

eissn

0018-506X

issn

1095-6867

pii

S0018-506X(10)00139-X

journal_volume

58

pub_type

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