Abstract：
:The neuronal nitric oxide synthase (nNOS) is involved in the control of male and female sexual behavior and its distribution in several regions of the limbic-hypothalamic system, as well as its coexistence with gonadal hormones' receptors, suggests that these hormones may play a significant role in controlling its expression. However, data illustrating the role of gonadal hormones in controlling the nNOS expression are, at present, contradictory, even if they strongly suggest an involvement of testosterone (T) in the regulation of nNOS. The action of T may be mediated through androgen (AR) or, after aromatization to estradiol (E(2)), through estrogen receptors. To elucidate the role of AR on nNOS expression, we compared male and female rats with a non-functional mutation of AR (Tfm, testicular feminization mutation) to their control littermates. We investigated some hypothalamic and limbic nuclei involved in the control of sexual behavior [medial preoptic area (MPA), paraventricular (PVN), arcuate (ARC), ventromedial (VMH) and stria terminalis (BST) nuclei]. In BST (posterior subdivision), VMH (ventral subdivision), and MPA we detected a significant sexual dimorphism in control animals and a decrease of nNOS positive elements in Tfm males compared to their littermate. In addition, we observed a significant increase of nNOS positive elements in BST (posterior) of Tfm females. No significant changes were observed in the other nuclei. These data indicate that, contrary to current opinions, androgens, through the action of AR may have a relevant role in the organization and modulation of the nNOS hypothalamic system.
journal_name
Horm Behavjournal_title
Hormones and behaviorauthors
Martini M,Di Sante G,Collado P,Pinos H,Guillamon A,Panzica GCdoi
10.1016/j.yhbeh.2008.05.015subject
Has Abstractpub_date
2008-09-01 00:00:00pages
557-64issue
4eissn
0018-506Xissn
1095-6867pii
S0018-506X(08)00169-4journal_volume
54pub_type
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
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journal_title：Hormones and behavior
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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