Abstract:
AIM AND PURPOSE:Radionuclide imaging of the kidneys using dimercaptosuccinic acid chelate labeled with technetium-99m (Tc-DMSA) is a well-established method for evaluating the extent of kidney parenchymal involvement in the scenario of urinary tract infection and for the estimation of the functional renal mass. We have developed a simplified technique, Bnai Zion Planar Method (BZPM), to estimate absolute DMSA uptake by the kidneys, which uses a shorter time of acquisition and does not require cumbersome calculations of attenuation correction. The aim of this study was to validate this technique by comparing it with the Quantitative DMSA single-photon emission computed tomography (SPECT) (QDMSA) measurements as the reference method. METHODS:Sixty-one consecutive children (mean age 5.4+/-4.8 years) were included in the study. Absolute uptake of the radiopharmaceutical by the kidneys was measured using the QDMSA SPECT methods described earlier with data acquisition of 20 min. Kidney volumes and radioactivity concentration measurements were calculated on the reconstruction data using the threshold method. For the simplified technique (BZPM), a planar posterior view of the kidneys was acquired for 1 min at the end of the QDMSA SPECT study. RESULTS:In both kidneys we observed a significant strong correlation between the two methods. BZPM measurements were very similar to those obtained using the validated QDMSA method, as determined by linear regression analysis (Pearson's r=0.924, P<0.001), r(2)=0.854. The uptake according to QDMSA can be predicted by the uptake measured by the BZPM method using the following regression equation: QDMSA=0.445+1.061 BZPM. CONCLUSION:BZPM estimation in children using the newly proposed planar method was found to be nearly identical to the validated QDMSA SPECT method.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Gorenberg M,Radan L,Kosakov R,Amirav Idoi
10.1097/MNM.0b013e3283396073subject
Has Abstractpub_date
2010-07-01 00:00:00pages
682-5issue
7eissn
0143-3636issn
1473-5628journal_volume
31pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVE:The most recent DNA analogues to become commercially available are known as locked nucleic acids (LNAs). The aim of this study was to evaluate the properties of LNAs for antisense targeting. METHODS:A 15 mer LNA antisense to RIalpha mRNA was studied in cell culture. The antisense LNA (5'-amine...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200411000-00008
更新日期:2004-11-01 00:00:00
abstract:AIM:To report our data concerning the changes in post-stress and at-rest left ventricular ejection fraction and ventricular volumes in patients with thallium gated SPECT. METHODS:Post-stress and at-rest thallium gated SPECT was performed in 629 consecutive patients; left ventricular ejection fraction (LVEF), left vent...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/01.mnm.0000167648.29853.93
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the accuracy of the sequential multiphase and dual-tracer (SMADT) technique utilizing technetium-99m pertechnetate (99mTcO4) and dynamic technetium-99m-2-methoxyisobutylisonitrile (99mTc-MIBI) with single-photon emission computed tomography/computed tomography (SPECT/CT) f...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000215
更新日期:2015-01-01 00:00:00
abstract::To evaluate right ventricular overload in paediatric patients with congenital cardiac disease (n = 25), the uptakes of 201Tl and 99Tcm-sestamibi (99Tcm-MIBI) were compared. 99Tcm-MIBI showed a clearer myocardial border and better contrast between the myocardium and ventricular cavity. Although hepatic activity may inf...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199511000-00010
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abstract::The advent of PET instrumentation signaled the beginning of a new perspective in nuclear medicine diagnostic imaging. PET systems rely on several corrections that must be applied in order to establish accurate and reliable quantification. The inherent properties of PET detector architecture and the crystals themselves...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0b013e328365ac1e
更新日期:2013-11-01 00:00:00
abstract::Alzheimer's disease is associated with a loss in presynaptic cholinergic function. It has been suggested that cholinergic inhibitors such as donepezil hydrochloride (Donepezil) could restore this function and improve some of the symptoms of Alzheimer's disease. Previous work has shown that Donepezil improves cognitive...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200001000-00007
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abstract::Changes in regional ejection fraction (rEF) of the interventricular septum following coronary artery bypass graft (CABG) surgery were examined using first-pass radionuclide ventriculography (RNVG) in patients without objective evidence of postoperative myocardial infarction (MI). One hundred and one patients had pre- ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::The level of Na(+)-K+ adenosine triphosphatase (ATPase) has been demonstrated to be correlated with tumour growth potential, and accelerated active transport of K+ carried out by Na(+)-K+ ATPase is said to be a trigger of 201Tl affinity for malignant tumour cells. Therefore, 201Tl scintigraphy appears to be a good ind...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199403000-00002
更新日期:1994-03-01 00:00:00
abstract::The presence of distant metastases is the main prognostic factor in patients with breast cancer and has a significant influence in the choice of therapy. Therefore, chest X-ray, bone scintigraphy and ultrasound of the abdomen are performed to detect distant metastases at diagnosis and follow-up. Fluorodeoxyglucose pos...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200209000-00009
更新日期:2002-09-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198701000-00002
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:The NHS National PET-CT Audit Programme was launched in 2008 as part of a national NHS programme to widen patient access to PET-computed tomography (CT) imaging in England. However, to implement clinical audit effectively, healthcare professionals need to be fully engaged with the process. The purpose of the pi...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000161
更新日期:2014-10-01 00:00:00
abstract:AIMS:To (a) assess the accuracy of 18F-FDG PET/CT in distinguishing malignant from benign pelvic lesions, compared to transvaginal ultrasonography (TVUS) and (b) to establish the role of whole-body 18F-FDG PET/CT, compared to contrast enhanced computed tomography (CT), in staging patients with ovarian cancer. PATIENTS...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e3281afa256
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:Concurrent inflammation or anemia at the time of PET/computed tomography (CT) could be one of several causes of diffuse splenic (18)F-fluorodeoxyglucose ((18)F-FDG) uptake. In this study, we focused on cytokines to investigate interactions during this phenomenon and clarify the significance of splenic (18)F-...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e3283595cac
更新日期:2013-01-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200506000-00002
更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/MNM.0000000000001190
更新日期:2020-06-01 00:00:00
abstract:AIM:The objective of this study was to assess the relevance of physiological (68)Ga-DOTATATE PET/CT findings in the pancreas guided by morphological imaging (MI) in comparison with pathological tumour uptake in patients with neuroendocrine tumours (NETs). METHODS:A total of 138 patients with pancreatic NET (pNET; n=38...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000106
更新日期:2014-06-01 00:00:00
abstract::Fractionation of 99Tcm-exametazime enables several patients doses to be prepared from one vial. To overcome the disadvantages of storage at -70 degrees C, storage at higher temperatures was investigated with replacement of stannous ions before use. Kits were fractionated using a nitrogen-purged 0.9% w/v sodium chlorid...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199903000-00013
更新日期:1999-03-01 00:00:00
abstract::Technetium-99m-sestamibi (99mTc-MIBI) imaging is a well-established modality in oncologic investigations. The current study aimed to investigate whether any relationship could be found between 99mTc-MIBI uptake and local perfusion in malignant bone and soft-tissue tumours. It also aimed to compare 99mTc-MIBI images wi...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200106000-00012
更新日期:2001-06-01 00:00:00
abstract::Findings of hepatobiliary scintigraphy with intravenous cholecystokinin octapeptide (sincalide) were examined in 26 asymptomatic patients with various malignancies but no known pre-existing gallbladder disease, and normal hepatobiliary and gallbladder morphology on sonography. The maximum gallbladder ejection fraction...
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doi:10.1097/00006231-200010000-00013
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doi:10.1097/00006231-200002000-00006
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199512000-00013
更新日期:1995-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/MNM.0000000000000550
更新日期:2016-10-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e3280708ecf
更新日期:2007-04-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::The investigation of left ventricular contractile reserve usually requires the determination of left ventricular volume, but its measurement with radionuclide angiography is difficult. The aim of this study was to determine left ventricular volume directly during exercise by the simultaneous measurement of peak exerci...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199612000-00007
更新日期:1996-12-01 00:00:00
abstract::Three ligand assays for TSH using monoclonal antibodies, an IRMA, an ELISA and a DELFIA were compared with a standard DAB RIA technique. The IRMA proved to be superior in respect to sensitivity, precision, reproducibility and practicality. The highest sensitivity yet, was achieved by DELFIA. IRMA, ELISA and DELFIA are...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
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更新日期:1985-04-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198910000-00008
更新日期:1989-10-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000353
更新日期:2015-10-01 00:00:00
abstract::In order to perform automatically the thresholding of the amplitude image obtained by phase analysis, a filter based on the probability density of the amplitude is proposed. It generates the image of the significant amplitude by setting to zero the amplitude if its square is lower than 4a0 log(1/alpha)/N where a0 is t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198710000-00005
更新日期:1987-10-01 00:00:00