Changes in the rCBF images of patients with Alzheimer's disease receiving Donepezil therapy.

Abstract:

:Alzheimer's disease is associated with a loss in presynaptic cholinergic function. It has been suggested that cholinergic inhibitors such as donepezil hydrochloride (Donepezil) could restore this function and improve some of the symptoms of Alzheimer's disease. Previous work has shown that Donepezil improves cognitive and global function in patients with mild to moderate Alzheimer's disease. This study reviewed retrospectively 12 patients who had previously had a 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) single photon emission tomography (SPET) regional cerebral blood flow (rCBF) examination and had gone on to receive Donepezil therapy. These patients were recalled for a further 99Tcm-HMPAO SPET rCBF examination and the image data sets were compared. The results showed an overall increase in global cerebral blood flow (P = 0.04) averaged over the group with a percentage change in blood flow ranging from -1.8% to 6.4%. However, some patients showed a slight decrease in blood flow. When the data were analysed in terms of regional cerebral blood flow, we found that the most significant increase in blood flow occurred in the frontal lobes (P = 0.02).

journal_name

Nucl Med Commun

authors

Staff RT,Gemmell HG,Shanks MF,Murray AD,Venneri A

doi

10.1097/00006231-200001000-00007

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

37-41

issue

1

eissn

0143-3636

issn

1473-5628

journal_volume

21

pub_type

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