Negative 18F-FDG-PET-CT may exclude residual or recurrent disease in anal cancer.

Abstract:

OBJECTIVES:The incidence of anal cancer is increasing in Western countries. Fluorine-18 fluorodeoxyglucose (F-FDG) PET-computed tomography (CT) is used in the assessment of anal cancer, but its routine use is not established. The aim of this study was to assess the value of F-FDG-PET-CT in staging and post-treatment assessment in anal cancer and to determine its impact on management. METHODS:This was a retrospective analysis of patients with anal cancer treated at the Sussex Cancer Centre who underwent PET-CT between November 2004 and September 2014. Information was retrieved from patient notes and the local cancer register, and verified by referring consultants in all cases. RESULTS:A total of 75 PET-CT scans in 52 patients were identified, representing 38.5% of patients diagnosed with anal cancer during this period. There were 24 staging scans and 51 post-treatment scans. Management was altered following 45.8% of staging scans and 56.0% of all scans, mostly changing treatment type or radiotherapy volume. Out of 28 positive post-treatment scans, 71.4% were true positives, 7.1% were false positives and 21.4% showed nonspecific uptake. Of the 23 negative post-treatment scans, all remained disease free at clinical/radiological follow-up (median follow-up 25 months). The sensitivity and specificity of post-treatment PET-CT were 100 and 74%, respectively. Negative predictive and positive predictive values were 100 and 71%, respectively. CONCLUSION:Evidence is evolving for the use of PET-CT in anal cancer. Because of a high negative predictive value, our series shows that PET-CT can be used in the assessment of treatment response to exclude residual/recurrent disease.

journal_name

Nucl Med Commun

authors

Teagle AR,Gilbert DC,Jones JR,Burkill GJ,McKinna F,Dizdarevic S

doi

10.1097/MNM.0000000000000560

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

1038-45

issue

10

eissn

0143-3636

issn

1473-5628

journal_volume

37

pub_type

杂志文章
  • Diagnostic accuracy of 18F-FDG PET/CT in characterizing ovarian lesions and staging ovarian cancer: correlation with transvaginal ultrasonography, computed tomography, and histology.

    abstract:AIMS:To (a) assess the accuracy of 18F-FDG PET/CT in distinguishing malignant from benign pelvic lesions, compared to transvaginal ultrasonography (TVUS) and (b) to establish the role of whole-body 18F-FDG PET/CT, compared to contrast enhanced computed tomography (CT), in staging patients with ovarian cancer. PATIENTS...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e3281afa256

    authors: Castellucci P,Perrone AM,Picchio M,Ghi T,Farsad M,Nanni C,Messa C,Meriggiola MC,Pelusi G,Al-Nahhas A,Rubello D,Fazio F,Fanti S

    更新日期:2007-08-01 00:00:00

  • False-positive F-18 FDG uptake in PET/CT studies in pediatric patients with abdominal Burkitt's lymphoma.

    abstract:INTRODUCTION:In pediatric patients with abdominal Burkitt's lymphoma, the involvement of the gastrointestinal tract and abdominal lymph nodes are the main presenting feature of the disease. Chemotherapy is the main treatment modality and could be preceded by surgical excision of the abdominal masses. To achieve cure or...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328334fc14

    authors: Riad R,Omar W,Sidhom I,Zamzam M,Zaky I,Hafez M,Abdel-Dayem HM

    更新日期:2010-03-01 00:00:00

  • Frequency and significance of physiological versus pathological uptake of 68Ga-DOTATATE in the pancreas: validation with morphological imaging.

    abstract:AIM:The objective of this study was to assess the relevance of physiological (68)Ga-DOTATATE PET/CT findings in the pancreas guided by morphological imaging (MI) in comparison with pathological tumour uptake in patients with neuroendocrine tumours (NETs). METHODS:A total of 138 patients with pancreatic NET (pNET; n=38...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000106

    authors: Mapelli P,Tam HH,Sharma R,Aboagye EO,Al-Nahhas A

    更新日期:2014-06-01 00:00:00

  • The use of dual-isotope imaging to compare the gastrointestinal transit of food and pancreatic enzyme pellets in cystic fibrosis patients.

    abstract::Cystic fibrosis patients require pancreatic enzyme supplements to aid food digestion. It is suspected that incorrect delivery of this enzyme may result in both significant malabsorption and the development of strictures in the proximal colon caused by the high-dose supplement reaching this region before the food. Inve...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199808000-00006

    authors: Hillel PG,Tindale WB,Taylor CJ,Frier M,Senior S,Ghosal S

    更新日期:1998-08-01 00:00:00

  • The role of IDA scintigraphy in the follow-up of liver disease in patients with cystic fibrosis.

    abstract::The main aim of this study was to investigate the role of N-(2,4,6 trimethyl-3-bromophenylcarbamoylmethyl) iminodiacetic acid (IDA; Mebrofenin) scintigraphy in follow-up assessments of the biliary system in patients with cystic fibrosis associated liver disease. Fourteen patients from a study published in 1996 were re...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200207000-00012

    authors: Foster JA,Ramsden WH,Conway SP,Taylor JM,Etherington C

    更新日期:2002-07-01 00:00:00

  • A pilot study of flaccid penile blood flow patterns in normal subjects and patients with erectile dysfunction.

    abstract::Dynamic penile scintigraphy was performed using 99Tcm-labelled autologous erythrocytes in five normally potent volunteers and 22 patients with erectile dysfunction including 11 patients with psychogenic and 11 patients with vasculogenic impotence (four arteriogenic, three venogenic, three arteriogenic and venogenic, o...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199311000-00007

    authors: Siraj QH,Hilson AJ,Bomanji J,Ahmed M

    更新日期:1993-11-01 00:00:00

  • Different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations: 99mTc-sestamibi in chemotherapy for breast tumours.

    abstract:AIM:This study was undertaken to evaluate different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations in the same individual. No standard exists for making digital evaluations at single-photon examinations. For this purpose, we employed a patien...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/01.mnm.0000202866.97787.45

    authors: Jacobsson H,Wilczek B,Bergh J,von Schoultz E,Eriksson E,Larsson SA

    更新日期:2006-04-01 00:00:00

  • Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin?

    abstract:OBJECTIVE:The clearance rate of inhaled 99mTc-sestamibi from the lungs of healthy nonsmoking individuals is much slower than would be expected from its physical properties. The clearance rate is even slower in healthy cigarette smokers. As 99mTc-sestamibi is a substrate for P-glycoprotein (P-gp), pulmonary P-gp may be ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e32832b9a2d

    authors: Cheow HK,Ruparelia P,Shankar S,Szczepura KR,Ballinger JR,Hartman NG,Chilvers ER,Peters AM

    更新日期:2009-08-01 00:00:00

  • A novel iterative method for lesion delineation and volumetric quantification with FDG PET.

    abstract:OBJECTIVES:The determination of lesion boundaries on FDG PET is difficult due to the point-spread blurring and unknown uptake of activity within a lesion. Standard threshold-based methods for volumetric quantification on PET usually neglect any size dependence and are biased by dependence on the signal-to-background ra...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e328155d154

    authors: van Dalen JA,Hoffmann AL,Dicken V,Vogel WV,Wiering B,Ruers TJ,Karssemeijer N,Oyen WJ

    更新日期:2007-06-01 00:00:00

  • A technique for the absolute quantification of 131I radiopharmaceuticals using SPECT.

    abstract::A technique is described for the quantification of the three-dimensional distribution of 131I radiopharmaceuticals using single photon emission computed tomography (SPECT). A theoretical discussion of the problems of scatter and septal penetration in 131I SPECT is presented. The correction of these effects using the g...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199306000-00014

    authors: Fleming JS,Alaamer AA,Perring S

    更新日期:1993-06-01 00:00:00

  • Evaluation of relative renal function for patients who had undergone simultaneous liver-kidney transplants using Tc-99m-MAG3 scintigraphy with attenuation correction from anatomical images and SPECT/CT.

    abstract:OBJECTIVE:Assessing the relative function of each of the three kidneys using nuclear scintigraphy with standard planar imaging in patients having undergone kidney transplant is problematic because of the different photon-attenuation factors associated with native versus transplanted kidneys. To address this, we applied...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328347e958

    authors: Palmer MR,Donohoe KJ,Francis JM,A Mandelbrot D

    更新日期:2011-08-01 00:00:00

  • Uptake of 2-[18F]fluoro-2-deoxy-D-glucose in uterine leiomyoma: imaging of four patients by coincidence positron emission tomography.

    abstract::Uterine leiomyomas, benign tumours of the human uterus, are the most common uterine neoplasm and are composed of smooth muscle with varying amounts of fibrous connective tissue. As a functional imaging modality, 2-[F]fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography can be used to obtain information about ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200409000-00012

    authors: Ak I,Ozalp S,Yalçin OT,Zor E,Vardareli E

    更新日期:2004-09-01 00:00:00

  • Diagnostic utility of 99mTc-EDDA-tricine-HYNIC-Tyr3-octreotate SPECT for differentiation of active from inactive pulmonary tuberculosis.

    abstract:OBJECTIVE:The current study was performed to evaluate the impact of Tc-EDDA-tricine-HYNIC-Tyr-octreotate in the differentiation of active from inactive pulmonary tuberculosis lesions. PATIENTS AND METHODS:Ten consecutive patients (six male and four female, age range 24-83 years) with proven pulmonary tuberculosis (wit...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000206

    authors: Ahmadihosseini H,Abedi J,Ghodsi Rad MA,Zakavi SR,Knoll P,Mirzaei S,Sadeghi R

    更新日期:2014-12-01 00:00:00

  • Intravenous administration of morphine sulfate in hepatobiliary imaging for acute cholecystitis: a review of clinical efficacy.

    abstract::Morphine sulfate has been used by several investigators in the cholescintigraphic diagnosis of acute cholecystitis. A review of the available literature indicates that morphine sulfate significantly reduces the total time required for the hepatobiliary examination, while retaining both high sensitivity (98.8%) and spe...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/00006231-198803000-00005

    authors: Vasquez TE,Rimkus DS,Pretorius HT,Greenspan G

    更新日期:1988-03-01 00:00:00

  • The role of 99mTc-labelled glucosamine (99mTc-ECDG) in the evaluation of rheumatic joint disease: a screening experience.

    abstract:OBJECTIVES:We investigated the localization pattern of a novel imaging agent, (99m)Tc-labelled glucosamine (ECDG), in a variety of rheumatic conditions. MATERIALS AND METHODS:Sixteen patients were recruited into the study, with either active rheumatoid arthritis or osteoarthritis. (99m)Tc-ECDG was prepared in-house an...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000096

    authors: Angelides S,El-Mashaleh M,Anagnostou M,Howe G,Spencer D,Kumar V,Manolios N

    更新日期:2014-06-01 00:00:00

  • Left ventricular ejection fraction determined with the nuclear stethoscope, gamma camera and contrast ventriculography.

    abstract::Left ventricular ejection fractions (EF) were measured with a nuclear stethoscope (NSt, beat-to-beat and ECG gated summation method) and contrast ventriculography (VG) immediately following one another (IFOA) (r X 0.96 and 0.95, respectively, n = 13). NSt and ECG gated gamma camera (MUGA) recordings IFOA were compared...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198605000-00003

    authors: Lund O,Rasmussen K,Jensen FT,Hansen HH

    更新日期:1986-05-01 00:00:00

  • Prospective evaluation of qualitative and quantitative ¹⁸F-FDG PET-CT parameters for predicting survival in recurrent carcinoma of the cervix.

    abstract:OBJECTIVE:The aim of this study was to evaluate the prognostic significance of qualitative and quantitative F-fluorodeoxyglucose (F-FDG) PET-computed tomography (PET-CT) parameters in patients with recurrent cervical carcinoma. METHODS:Twenty-six patients (age: 44 ± 10.1 years) with histologically proven recurrent car...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e3283622f0d

    authors: Maharjan S,Sharma P,Patel CD,Sharma DN,Dhull VS,Jain SK,Thulkar S,Malhotra A,Kumar R

    更新日期:2013-08-01 00:00:00

  • Diagnostic accuracy of combined 99mTc-sulesomab and 99mTc-nanocolloid bone marrow imaging in detecting prosthetic joint infection.

    abstract:OBJECTIVE(S):Autologous-labeled leukocytes combined with sulfur colloid bone marrow scan is the current nuclear medicine gold standard for the diagnosis of prosthetic joint infection. The goal of this study is to assess the diagnostic accuracy of a new nuclear medicine modality for detecting infection in this context. ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e3283496695

    authors: Sousa R,Massada M,Pereira A,Fontes F,Amorim I,Oliveira A

    更新日期:2011-09-01 00:00:00

  • Criteria for the use of monoclonal antibodies, legislation and ethical considerations.

    abstract::The criteria governing the in vivo use of monoclonal antibodies in humans are based upon a number of legal requirements with respect to radiation hygiene, pharmaceutical legislation, radiopharmaceutical legislation and regulations with respect to products arising from biotechnology. This in itself has led to a complic...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199308000-00005

    authors: Cox PH

    更新日期:1993-08-01 00:00:00

  • 18F-FDG PET/CT findings of radiotherapy-related myocardial changes in patients with thoracic malignancies.

    abstract:OBJECTIVE:The purpose of this study was to investigate myocardial findings of F-fluorodeoxyglucose PET/computed tomography (F-FDG PET/CT) after thoracic radiotherapy. METHODS:F-Fluorodeoxyglucose PET/CT examination was performed in 38 patients at least 4 months after radiotherapy. Patients with known cardiac diseases,...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328362f824

    authors: Unal K,Unlu M,Akdemir O,Akmansu M

    更新日期:2013-09-01 00:00:00

  • Comparison of fluorodeoxyglucose positron emission tomography and "conventional diagnostic procedures" for the detection of distant metastases in breast cancer patients.

    abstract::The presence of distant metastases is the main prognostic factor in patients with breast cancer and has a significant influence in the choice of therapy. Therefore, chest X-ray, bone scintigraphy and ultrasound of the abdomen are performed to detect distant metastases at diagnosis and follow-up. Fluorodeoxyglucose pos...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200209000-00009

    authors: Dose J,Bleckmann C,Bachmann S,Bohuslavizki KH,Berger J,Jenicke L,Habermann CR,Jãnicke F

    更新日期:2002-09-01 00:00:00

  • Diagnostic performance of a novel dedicated breast PET scanner with C-shaped ring detectors.

    abstract:BACKGROUND:A dedicated breast PET scanner with C-shaped detectors (C scanner) has been newly developed. The purpose of this study was to re-evaluate the diagnostic performance of high-resolution PET images with the new reconstruction conditions, obtained using this C scanner in breast cancer patients, and to compare th...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000661

    authors: Nakamoto R,Nakamoto Y,Ishimori T,Nishimatsu K,Miyake KK,Kanao S,Iima M,Toi M,Togashi K

    更新日期:2017-05-01 00:00:00

  • Specifying dual-detector gamma cameras and associated computer systems.

    abstract::Increasingly, dual-detector gamma cameras are being purchased as replacements for single-headed cameras. The improvement in sensitivity offered by a dual-detector device can be used in several ways: to shorten acquisition times, to improve signal-to-noise ratios, or to reduce administered doses. This paper focuses on ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/00006231-199507000-00003

    authors: Tindale WB

    更新日期:1995-07-01 00:00:00

  • Quantitative assessment of cardiac mechanical dyssynchrony and prediction of response to cardiac resynchronization therapy in patients with nonischaemic dilated cardiomyopathy using gated myocardial perfusion SPECT.

    abstract:OBJECTIVE:The aim of the study was to evaluate gated myocardial perfusion SPECT (GMPS) in the prediction of response to cardiac resynchronization therapy (CRT) in nonischaemic dilated cardiomyopathy patients. PATIENTS AND METHODS:Thirty-two patients (23 men, mean age 57.5±12.1 years) with severe heart failure, who wer...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0000000000000282

    authors: Mukherjee A,Patel CD,Naik N,Sharma G,Roy A

    更新日期:2015-05-01 00:00:00

  • Immediate 201Tl reinjection: an alternative approach in myocardial perfusion scintigraphy? A comparison with contrast angiographic findings.

    abstract::Thallium-201 (201Tl) stress-redistribution/reinjection imaging provides a reliable diagnostic approach in patients evaluated for myocardial ischaemia. Immediate reinjection of 201Tl after completing the stress images followed by imaging 1 h later shortens the investigation time to 2.5 h and may provide a novel approac...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:

    authors: van Eck-Smit BL,van der Wall EE,Zwinderman AH,Pauwels EK

    更新日期:1995-10-01 00:00:00

  • Role of 18F-FDG PET/CT in evaluating molecular subtypes and clinicopathological features of primary breast cancer.

    abstract:OBJECTIVE:In this study, primary tumors' fluorine-18-fluorodeoxyglucose (F-FDG) uptake in luminal A, luminal B, triple-negative, and human epidermal growth factor receptor type-2 subtypes of breast cancer was evaluated. In addition, the relationship between the primary tumor maximum standardized uptake value (SUVmax) v...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000856

    authors: Arslan E,Çermik TF,Trabulus FDC,Talu ECK,Başaran Ş

    更新日期:2018-07-01 00:00:00

  • Impact of fluorodeoxyglucose PET on the management of esophageal cancer.

    abstract::Esophageal cancer is the third most common malignancy of the alimentary tract. The incidence of esophageal cancer has steadily increased over the past three decades. Almost all therapeutic modalities for esophageal cancer are associated with a considerable mortality and morbidity. Consequently, there has been growing ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0b013e32831af204

    authors: Salavati A,Basu S,Heidari P,Alavi A

    更新日期:2009-02-01 00:00:00

  • Interpretation, accuracy and management implications of FDG PET/CT in cutaneous malignant melanoma.

    abstract:PURPOSE:To investigate the accuracy of different interpretative approaches and to evaluate the management implications of fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in cutaneous malignant melanoma. METHODS:We retrospectively identified 60 consecutive patients who underwent 76 PET/...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e3280708ecf

    authors: Falk MS,Truitt AK,Coakley FV,Kashani-Sabet M,Hawkins RA,Franc B

    更新日期:2007-04-01 00:00:00

  • Effective dose to children and adolescents from radiopharmaceuticals.

    abstract::Published values of tissue weighting factors for adolescents and children derived from the life-span study of the atomic bomb survivors have been used to calculate the effective dose to patients aged 1, 5, 10 and 15 years undergoing a common paediatric procedure requiring one of the following radiopharmaceuticals: 99T...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199906000-00012

    authors: Gadd R,Mountford PJ,Oxtoby JW

    更新日期:1999-06-01 00:00:00

  • The influence of hypercholesterolaemia on the adrenal uptake and metabolic handling of 131I-6 beta-iodomethyl-19-norcholesterol (NP-59).

    abstract::The biodistribution of 131I-6 beta-iodomethyl-19-norcholesterol (NP-59) was assessed in hypercholesterolaemic patients and in a rabbit model of HC to examine the alterations in the relative distribution of NP-59 and its metabolites and to explain the changes in the patterns of adrenal cortical imaging in patients with...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198608000-00010

    authors: Lynn MD,Gross MD,Shapiro B,Bassett D

    更新日期:1986-08-01 00:00:00