Abstract:
:The level of Na(+)-K+ adenosine triphosphatase (ATPase) has been demonstrated to be correlated with tumour growth potential, and accelerated active transport of K+ carried out by Na(+)-K+ ATPase is said to be a trigger of 201Tl affinity for malignant tumour cells. Therefore, 201Tl scintigraphy appears to be a good indicator for evaluation of changes of tumour proliferative potential after treatment. In the present study, the usefulness of 201Tl scintigraphy for monitoring radiotherapeutic effects was evaluated in VX-2 tumours irradiated with variable doses (10-40 Gy of radiation). Changes in 201Tl uptake were compared with tumour growth, and 201Tl uptake on day 7 after irradiation was compared with tumour bromodeoxyuridine (BrdU) uptake, which reflects DNA synthesis. All the treated tumours showed dose-dependent diminished 201Tl uptake, accompanied by either dose-dependent tumour growth delay or tumour regression/resolution. The diminished 201Tl uptake had already appeared on day 7 after irradiation, accompanied by diminished BrdU uptake, although, at this time, the tumour volumes were increased, or were not significantly decreased compared to pre-irradiation. Moreover, the 20 Gy tumours demonstrated two different tumour growth patterns, each accompanied by a different degree of reduction of 201Tl uptake. These findings suggest that the degree of reduction of tumour 201Tl uptake following irradiation can reflect the degree of suppressed proliferative activity in the treated tumours, and that assessment of altered 201Tl uptake at a relatively early time following irradiation allows prediction of subsequent tumour growth, regardless of the tumour volume.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Suga K,Nishigauchi K,Fujita T,Nakanishi Tdoi
10.1097/00006231-199403000-00002subject
Has Abstractpub_date
1994-03-01 00:00:00pages
128-39issue
3eissn
0143-3636issn
1473-5628journal_volume
15pub_type
杂志文章abstract::Sodium iodide (131I) capsules are widely used for both diagnosis and therapy. The radiochemical purity of both diagnostic and therapeutic capsules in use in Australia was studied by gel chromatography, high voltage electrophoresis and paper chromatography. It was found that in two of the three bands of therapeutic cap...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198611000-00007
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVES:As PET has become a standard of treatment in patients with cancer, publications of oncologic PET have grown sharply. We aimed to organize the data of meta-analyses of oncologic PET and assess the quality of studies. MATERIALS AND METHODS:The inclusion criteria were studies that meta-analyzed to combine the ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,meta分析
doi:10.1097/MNM.0000000000000908
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Renal ischemia-reperfusion injury (RIRI) may occur secondary to several reasons leading to renal failure. Coenzyme-Q10 (CoQ10) is a well-known antioxidant. However, the effects CoQ10 against RIRI have not been evaluated. Our aim was to evaluate protective effects of CoQ10 to renal ischemia-reperfusion by bioche...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001070
更新日期:2019-10-01 00:00:00
abstract::Conventional nuclear medicine methods for measuring glomerular filtration rate, GFR, are invalidated if the initial injection of radiopharmaceutical is tissued. An analytical method proposed by Veall and Gibbs in 1982 overcomes this difficulty but does require multiple blood samples. This paper investigates whether it...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198611000-00003
更新日期:1986-11-01 00:00:00
abstract::This study combines the pharmacologically-induced penile erection (PIPE) technique with radionuclide phallography (RNP) for the non-invasive study of penile haemodynamic changes during erection. Penile erections produced by the intracavernosal injections of two different vasoactive drugs, prostaglandin E1 (PGE1) and p...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199006000-00007
更新日期:1990-06-01 00:00:00
abstract::Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring >90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5-2% of hypertensive children. Gastroenteropancreatic NETs can occ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001305
更新日期:2021-01-01 00:00:00
abstract::Changes in regional ejection fraction (rEF) of the interventricular septum following coronary artery bypass graft (CABG) surgery were examined using first-pass radionuclide ventriculography (RNVG) in patients without objective evidence of postoperative myocardial infarction (MI). One hundred and one patients had pre- ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Lymph node metastases are significant prognostic factors in localized non-small-cell lung cancer (NSCLC). Nodal micrometastases may not be detected using current histological methods. AIM:To determine the accuracy and role of sentinel lymph nodes (SLNs) in patients with NSCLC. METHODS:Intraoperative techne...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/01.mnm.0000169381.99894.2f
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:Two ligands viz. tert-butyl dithiocarbamate (TBDTC) and methoxyisobutyl dithiocarbamate (MIBDTC), which are analogous to the tert-butyl isonitrile (TBI) and sestamibi (MIBI) ligands, were synthesized and labelled with the [99mTcN] core to evaluate their potential as myocardial agents. As these complexes have ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000183793.51474.2f
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate gated myocardial perfusion SPECT (GMPS) in the prediction of response to cardiac resynchronization therapy (CRT) in nonischaemic dilated cardiomyopathy patients. PATIENTS AND METHODS:Thirty-two patients (23 men, mean age 57.5±12.1 years) with severe heart failure, who wer...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000282
更新日期:2015-05-01 00:00:00
abstract::To evaluate 201Tl in the detection of the primary tumour, lymph node involvement and mediastinal spread we have studied a total of 188 patients with histologically proven lung cancer, breast cancer or malignant lymphoma. Ten patients with benign lung disease were also examined. Static images were performed 20 min afte...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199004000-00002
更新日期:1990-04-01 00:00:00
abstract::A postal survey of UK nuclear medicine departments was undertaken to collate information on equipment, numbers of procedures and staffing levels for the years 1992 and 1993. It was estimated that there are 235 sites undertaking nuclear medicine, the total number of procedures performed being some 490,000 in 1993 compa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199601000-00002
更新日期:1996-01-01 00:00:00
abstract::Captopril renography is used for the non-invasive diagnosis of renovascular hypertension, but suffers from the drawbacks of lower sensitivity and false-positive tests due to a fall in blood pressure. Aspirin renography has been proposed as a useful test for evaluation of unilateral renal artery stenoses of moderate de...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200004000-00006
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:PET/computed tomography (CT) imaging with the sodium-(F)-fluoride/2-(F)-fluoro-2-deoxy-D-glucose (F-NaF/F-FDG) cocktail has been proposed for patients with osseous metastases. This work aimed to optimize the cocktail composition for patients with metastatic castration-resistant prostate cancer (mCRPC). MATE...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000383
更新日期:2015-12-01 00:00:00
abstract::Using platelet scintigraphy to evaluate early thrombogenicity, we examined 39 new vascular accesses 4 weeks and 3 months after surgery. We found a significant association between platelet deposition and Doppler flow (P < 0.01) and blood pressure (P < 0.01). Compared with arteriovenous fistulae, prosthetic grafts showe...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199905000-00008
更新日期:1999-05-01 00:00:00
abstract::Tumour uptake of the inert, neutral complex 67Ga-9N3 and the tumour:blood concentration ratio (1,4,7,triazacyclononane-1,4,7, triacetic acid) were measured in mice bearing xenografts of the human melanotic melanoma HX118. Between 1 and 4 h after the injection the tumour:blood ratio increased from 3.5 to 21 and the con...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199209000-00006
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate myocardial findings of F-fluorodeoxyglucose PET/computed tomography (F-FDG PET/CT) after thoracic radiotherapy. METHODS:F-Fluorodeoxyglucose PET/CT examination was performed in 38 patients at least 4 months after radiotherapy. Patients with known cardiac diseases,...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328362f824
更新日期:2013-09-01 00:00:00
abstract::A comparative study of bone marrow scintigraphy using 99Tcm-nanocolloid, conventional bone scintigraphy and bone marrow biopsy were performed in 35 patients with histologically proven small cell carcinoma of the lung to determine whether bone marrow scintigraphy has a role in the early detection of bone marrow metasta...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199401000-00006
更新日期:1994-01-01 00:00:00
abstract::Technetium-99m-sestamibi (99mTc-MIBI) imaging is a well-established modality in oncologic investigations. The current study aimed to investigate whether any relationship could be found between 99mTc-MIBI uptake and local perfusion in malignant bone and soft-tissue tumours. It also aimed to compare 99mTc-MIBI images wi...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200106000-00012
更新日期:2001-06-01 00:00:00
abstract::We performed in vitro aggregation and indium-111 labeled platelet kinetic and biodistribution studies in seven patients with diabetes mellitus and in five control subjects. All subjects were male. All diabetic patients were poorly controlled at the time of study with blood glucose greater than 140 mg % and hemoglobin ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198803000-00006
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, foll...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000684
更新日期:2017-07-01 00:00:00
abstract::System upgrades are a constant feature of many highly technical specialties and are normally assumed to have a negligible effect on patient data. We report on the assessment of an upgrade made to a Norland XR-26 dual-energy X-ray absorptiometry (DXA) system. The upgraded version (2.3) consisted of new hip positioning ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199604000-00161
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVES:Concurrent inflammation or anemia at the time of PET/computed tomography (CT) could be one of several causes of diffuse splenic (18)F-fluorodeoxyglucose ((18)F-FDG) uptake. In this study, we focused on cytokines to investigate interactions during this phenomenon and clarify the significance of splenic (18)F-...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e3283595cac
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Positron emission tomography (PET) imaging using [18F]fluorodeoxyglucose (18F-FDG) is recognized to have a major role in oncological imaging. Over recent years there has been a steady increase in the use of gamma camera PET (GCPET) systems as these are less expensive than dedicated PET scanners and facilitat...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/01.mnm.0000130239.76326.ca
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Image-derived input function (IDIF) from carotid arteries is an elegant alternative to full arterial blood sampling for brain PET studies. However, a recent study using blood-free IDIFs found that this method is particularly vulnerable to patient motion. The present study used both simulated and clinical [11...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328356185c
更新日期:2012-09-01 00:00:00
abstract::The term 'fever of unknown origin' includes a wide range of conditions that often remain undiagnosed. The possibility of an infection must be promptly diagnosed in order to begin appropriate therapy. Imaging with radiopharmaceuticals, computed tomography, magnetic resonance imaging and ultrasound are the most commonly...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,meta分析,评审
doi:10.1097/00006231-200603000-00003
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:The NHS National PET-CT Audit Programme was launched in 2008 as part of a national NHS programme to widen patient access to PET-computed tomography (CT) imaging in England. However, to implement clinical audit effectively, healthcare professionals need to be fully engaged with the process. The purpose of the pi...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000161
更新日期:2014-10-01 00:00:00
abstract::Patients with acute arterial occlusion may suffer from significant muscle necrosis. It is important to determine the amount of regional muscle necrosis for prognostic purposes and evaluation of therapy. We have used technetium-99m-pyrophosphate (PPi) with single photon emission computed tomography (SPECT) to quantitat...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199002000-00009
更新日期:1990-02-01 00:00:00
abstract::Dual-isotope studies using 123I and 201Tl allow the assessment of sympathetic reinnervation in patients following heart transplantation. 123I-meta-iodobenzyl guanidine (123I-MIBG) serves as a tracer of the integrity of the sympathetic nervous system. 201Tl is used for landmarking to allow better delineation of the myo...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199508000-00009
更新日期:1995-08-01 00:00:00
abstract::The results of scintigraphy in 29 patients with Cushing's syndrome were evaluated. It was possible to separate bilateral hyperplasia from unilateral abnormality. In cases of unilateral abnormality correct localization of the tumour was accomplished and it was possible to visualize adrenocortical carcinoma. The many ad...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198501000-00005
更新日期:1985-01-01 00:00:00