Abstract：
:Alcoholism is a major and world-wide health problem. A characteristic pattern of congenital defects, known as the fetal alcohol syndrome, has been detected in the offspring of mothers who are chronic alcoholics. The mechanism underlying the teratogenic effects of ethanol is not known. An important hypothesis is that ethanol becomes teratogenic by inducing maternal/fetal nutritional deficiencies. Nutrients affected by ethanol consumption include methionine and zinc. Epidemiological and experimental studies have shown that zinc deficiency is associated with both fetal growth retardation and developmental defects. Furthermore, the ethanol metabolizing enzyme, alcohol dehydrogenase, is a zinc metalloenzyme. Zinc deficiency decreases alcohol dehydrogenase activity and thus slows down elimination of ethanol. Methionine, an essential amino acid, is a lipotrope, as well as a universal methyl donor. It is involved in hepatic detoxification. Studies on the effects of methionine and zinc might lead to appropriate therapeutic intervention in pregnancies of alcoholic mothers who are at a risk of giving birth to an impaired offspring. Furthermore, the results of such investigations will provide a better understanding of the mechanism of action of ethanol on the embryo.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Seyoum GG,Persaud TVdoi
10.1016/0306-9877(91)90185-2subject
Has Abstractpub_date
1991-02-01 00:00:00pages
153-6issue
2eissn
0306-9877issn
1532-2777pii
0306-9877(91)90185-2journal_volume
34pub_type
杂志文章abstract：:The few existing hypotheses for the function of the human hymen are weak. These are briefly reviewed, and a new hypothesis is proposed. We suggest that the appearance of the juvenile human hymen is based on 'premature' birth, following which infant helplessness and a subsequent advantage for vaginal protection from ex...
journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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更新日期：1996-04-01 00:00:00
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journal_title：Medical hypotheses
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更新日期：2018-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1986-04-01 00:00:00
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2000-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1231
更新日期：2001-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1994-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.07.044
更新日期：2009-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.04.041
更新日期：2013-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.05.026
更新日期：2009-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
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更新日期：2000-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2020-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.09.033
更新日期：2010-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 信件
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更新日期：2020-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2017-09-01 00:00:00
