Abstract：
INTRODUCTION:Hepatic veno-occlusive disease (VOD) is a life threatening complication after stem cells transplantation (SCT). Its prediction, precise diagnosis and treatment remain unclear. OBJECTIVE:Our goals were to determine the incidence, outcome and changes in haemostatic parameters in patients with VOD. Also, we tried to determine coagulation disturbances and their practical significance in early diagnosis of such patients. METHODS:We prospectively evaluated all consecutive VOD patients after SCT, aged 3 months to 17 years, from February 2004 to July 2008 treated at the Mother and Child Health Institute of Serbia "Dr Vukan Cupić" (IMD). All patients were diagnosed according to the Seattle criteria. The values of PT, aPTT, fibrinogen, FVIII, AT and vWF were measured on the day prior to the initiation of conditioning regiment and on the days 1, 7 and 14 from the moment of VOD diagnosis. Laboratory testing was performed in the IMD haemostasis laboratory and results were statistically evaluated. RESULTS:During the study period 74 SCT were performed at IMD. VOD developed 11 patients; 10 of 46 were autologous and 1 of 28 allogeneic SCT patients. In our group of patients the incidence of VOD was 14.8%. VOD was classified as mild in 7, moderate in 1 and severe in 3 patients. At the moment of establishing the diagnosis all patients had a significantly increased activity of vWF, FVIII and fibrinogen, and decreased AT. All of them were dependent on platelet transfusions. CONCLUSION:Platelet transfusion dependence suggests coagulation activation with great significance and indicates a possible development of VOD. Our results also suggest that monitoring coagulation parameters levels in the first five days from the establishment of diagnosis may have a significant predictive value for VOD outcome.
journal_name
Srp Arh Celok Lekjournal_title
Srpski arhiv za celokupno lekarstvoauthors
Jevtić D,Vujić D,Zecević Z,Veljković D,Gazikalović S,Elezović Idoi
10.2298/sarh10s1033jsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
33-8eissn
0370-8179issn
2406-0895journal_volume
138 Suppl 1pub_type
杂志文章abstract：INTRODUCTION:The causes of acute tubulointerstitial nephritis can be grouped into four broad categories: medications, infections, immunologic diseases, or idiopathic processes. Here we report a 17-year-old female who developed acute kidney injury (AKI) due to granulomatous interstitial nephritis (GIN) associated with i...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:Actual diagnostic sriteria are represented by a large spectar of data proposed by certain authors, so generally accepted protocole does not exist for similar clinical states i.e. asthmatic bronchitis, recurrent bronchitis and bronchial asthma in childhood, there is a different diagnostic terminology. Our clinical expe...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：Introduction:The anterior and middle superior alveolar nerve block was claimed to be unpredictably efficient for clinical application. Objective:The aim of this report was to establish the efficacy of the anterior and middle superior alveolar nerve block, applied with a computer-controlled injection system or a conven...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2016-09-01 00:00:00
abstract：INTRODUCTION:Compliance with hypertension guidelines in clinical practice is generally poor, but there was no data about compliance with any guidelines in general practice in Slovenia. OBJECTIVE:Our aim was to find out whether general practitioners in Slovenia managed their hypertensive patients according to the natio...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0704191p
更新日期：2007-03-01 00:00:00
abstract：:The article dealing with thyroid gland cancer in Yugoslavia is based on data on the mortality rate over the period from 1971 to 1985. During the observed period the average proportion of thyroid gland cancer was 0.51% (males-0.30%; females-0.81%) in the whole group of malignant tumours in Yugoslavia. In the same perio...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：INTRODUCTION:In the last few years, an increasing number of patients suffering from terminal renal disease of various leading causes was treated with renal replacement therapy. Peritonaeal dialysis involves an exchange of water and solutes between blood in the peritonaeal capillaries and dialysate in the peritonaeal ca...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0512498j
更新日期：2005-11-01 00:00:00
abstract：:Blood pressure measurements obtained in a physicians office may not reflect the patients blood pressure during the whole day. Ambulatory blood pressure monitoring provides information about blood pressure during normal daily activities and night sleep. Further, the results of ambulatory blood pressure monitoring are i...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:The bone disease in chronic renal failure patients with secondary hyperparathyroidism is usually termed renal osteodystrophy. Radiographic methods have been applied in renal bone disease mainly to discover lesions on long bones, hands and fee. During the evaluation of hormonal disturbances of hemodialysed chronic rena...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Lipid and lipoprotein disorders are well known risk factors for atherosclerosis and its complications. The level of atherogenic LDL-cholesterol (LDL-C) is directly related to an increased risk of occurrence and progression of ischemic heart disease. Epidemiological and clinical studies have shown that the use of stati...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：10.2298/sarh1302104s
更新日期：2013-01-01 00:00:00
abstract：:In the last decades of this century we are witnesses of frequent crises in different parts of the world produced by internal disturbance and wars. These crises, together with natural disasters, poverty and hunger, follow the history of mankind often forcing huge population groups to leave their homes. The harmful heal...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 社论
doi：
更新日期：1997-07-01 00:00:00
abstract：:Rubinstein-Taybi syndrome is a malformation occurring with approximate incidence of 1 per 10,000 live-born children. The diagnosis is usually based on specific facial dysmorphism in neonatal period, as well as on characteristic deformities of the hands and feet. Our study presents a male child who was diagnosed to hav...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh04s1109g
更新日期：2004-10-01 00:00:00
abstract：INTRODUCTION:Treatment of carotid stenosis could be surgical: eversion endarterectomy, conventional endarterectomy and patch-plasty, resection with graft interposition and bypass procedure or, in the past few years, carotid artery angioplasty (PTA) with stent implantation. OBJECTIVE:The aim of this study is to present...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0810494c
更新日期：2008-09-01 00:00:00
abstract：INTRODUCTION:Because apical periodontitis is recognizably an infectious disease, elimination or reduction of intracanal bacteria is of utmost importance for optimum treatment outcome. OBJECTIVE:The prevalence of Enterococcus faecalis and Porphyromonas gingivalis in infected root canals was studied Also, the effect of ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1410535s
更新日期：2014-09-01 00:00:00
abstract：:Ewing's tumor of bone is the second primary malignant bone tumor. Localized lesion is found in nearly 80% of cases and metastatic lesions are present in 20% at the time of diagnosis. Treatment protocols were analyzed, prognostic parameters were evaluated, and overall survival as well as survival until relapse of disea...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0610420s
更新日期：2006-09-01 00:00:00
abstract：INTRODUCTION:Ankylosing spondylitis is a chronic progressive autoimmune inflammatory disorder involving mainly the axial skeleton and larger peripheral joints that progressively limits spinal mobility and may lead to irreversible structural changes and consequently to impaired physical function and reduced quality of l...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0910524m
更新日期：2009-09-01 00:00:00
abstract：INTRODUCTION:Endovascular aneurysm repair (EVAR) has been introduced into clinical practice at the beginning of the 90's of the last century. Because of economic, political and social problems during the last 25 years, the introduction of this procedure in Serbia was not possible. OBJECTIVE:The aim of this study was t...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0902010d
更新日期：2009-01-01 00:00:00
abstract：:It is widely accepted that alcohol metabolism passes through different mechanisms: alcohol dehydrogenase (ADH) activity in stomach epithelial cells, activity of ADH in the liver, microsomal-ethanol-oxydizing system (MEOS), hepatocyte catalase activity, and nonoxydizing metabolic pathway (production of fatty acid ethyl...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：
更新日期：1996-09-01 00:00:00
abstract：INTRODUCTION:Gluten-free diet (GFD) presents the basis of coeliac disease (CD) treatment. If strictly applied, the disorders of the small bowel mucosa and other disease signs rapidly resolve. OBJECTIVE:The goal of the study was to evaluate the effect of GFD on the growth and nutritional status of children with the cla...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0912632r
更新日期：2009-11-01 00:00:00
abstract：:Low-grade astrocytomas comprise a group of primary brain neoplasms with relatively low anaplastic potential, although through time they tend to behave more aggressively. They have a very heterogeneous natural course and clinical behavior. This report presents a natural history of a patient with low grade astrocytoma. ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0612537r
更新日期：2006-11-01 00:00:00
abstract：INTRODUCTION:Every clinical trial has to meet all ethical criteria in addition to the scientific ones. The basic ethical principles in the clinical trials are the following: nonmaleficence, beneficence, respect for autonomy and the principle of justice. OBJECTIVE:The aim of the study was to analyse clinical cases with...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1310659m
更新日期：2013-09-01 00:00:00
abstract：:Diagnostics in patients with the acute coronary syndromes (ACS) is becoming even more complex with the increase of number of available options. In addition, the number of treatment options accessible to patients with ACS keeps on growing rapidly. Physicians must now choose from a wide variety of antiplatelet and antit...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-01 00:00:00
abstract：INTRODUCTION:Dyslexia represents a significant pediatric problem requiring prompt and appropriate treatment. OBJECTIVE:The aim of this study was to examine the significance of integral rehabilitation approach in treating dyslexia of children. METHODS:Objectives of the study were accomplished on a sample of 300 childr...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1210625s
更新日期：2012-09-01 00:00:00
abstract：:A sudden onset of the syndrome Guillain-Barré in 48-year-old woman presenting as an acute motor neuropathy was associated with antibodies against ganglioside GM1 detected by ELISA. The neurological examination revealed flaccid quadriplegia without affection of the sensory system, and the additional investigation showe...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:The occurrence of abnormal Hodgkin's and Reed-Sternberg cells in the peripheral blood in a patient suffering from Hodgkin's disease has been noticed exceptionally rare in a previous period, and especially rare in last ten years primarily due to successful treatment of this disease. The presence of atypical mononuclear...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0310400m
更新日期：2003-09-01 00:00:00
abstract：:Cardiovascular disorders are the most frequent cause of death (46-60%) among patients with advanced chronic renal failure (CRF), and on dialysis treatment. Uremic cardiomyopathy is the basic pathophysiologic substrate, whereas ischemic heart disease (IHD) and anemia are the most important contributing factors. Associa...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：10.2298/sarh1412747p
更新日期：2014-11-01 00:00:00
abstract：INTRODUCTION:Lipid peroxidation and antioxidant systems are important factors affecting the metabolism of lipoproteins in diabetes mellitus. OBJECTIVE:The aim of this study was to investigate the lipid and antioxidant parameters in type II diabetes mellitus patients, and also to determine the effect of diabetic compli...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0704143k
更新日期：2007-03-01 00:00:00
abstract：INTRODUCTION:Neurofibromatosis type 1 is one of the most common genetically transmitted diseases with a high index of spontaneous mutations and extremely varied and unpredictable clinical manifestations. It is diagnosed by the existence of certain clinical criteria. The presence of numerous localised cutaneous neurofib...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0806295t
更新日期：2008-05-01 00:00:00
abstract：:Subtrochanteric fractures of the femur have a special place because of a significant number of complications following treatment. Powerful loading forces asymmetrically acting to this bone segment, as well as poor vascularization interfere with bone union. There are basically two current approaches in the fixation of ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：10.2298/sarh1108540v
更新日期：2011-07-01 00:00:00
abstract：:Two patients with normal-pressure hydrocephalus were assessed with Luria Nebraska Neuropsychological Battery, before ventriculo-atrial shunting and six months later. The best improvement was recorded in attention, visuospatial and intellectual functions. It is well documented that normal-pressure hydrocephalus dementi...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Etiopathogenesis of inflammatory processes of the urinary tract, mainly of obstructive uropathy and chronic pyelonephritis, is reviewed. The most frequent cause of obstruction is renal calculosis; in the pathogenesis of chronic pyelonephritis the following factors are of great importance: renal and urethral anomalies,...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
