[Modern statin therapy in clinical practice: the lower the better].

Abstract:

:Lipid and lipoprotein disorders are well known risk factors for atherosclerosis and its complications. The level of atherogenic LDL-cholesterol (LDL-C) is directly related to an increased risk of occurrence and progression of ischemic heart disease. Epidemiological and clinical studies have shown that the use of statin therapy to decrease LDL-C can significantly reduce the incidence of mortality, major coronary events and the need for revascularization procedures in the different groups of patients. The findings of a large meta-analysis conducted by the Cholesterol Treatment Trialists' (CTT) collaborators showed that every 1.0 mmol/l reduction of atherogenic LDL-C is associated with a 22% reduction in cardiovascular diseases mortality and morbidity. However, despite the impressive results of the benefits of statin therapy, the EUROASPIRE study showed that about 50% of patients with ischemic heart disease did not achieve target LDL-C levels. According to the new ESC/EAS Guidelines for the Management of Dyslipidaemias in patients with a very high cardiovascular risk, treatment goal should be to decrease LDL-C below 1.8 mmol/l or > or = 50% of initial values. In the majority of patients that can be achieved by statin therapy. For this reason an adequate choice of statins is of crucial importance, whereby the needed reduction in atherogenic LDL-C, after the identification of its target level based on the assessment of total cardiovascular risk, can be achieved.

journal_name

Srp Arh Celok Lek

authors

doi

10.2298/sarh1302104s

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

104-8

issue

1-2

eissn

0370-8179

issn

2406-0895

journal_volume

141

pub_type

杂志文章,评审
  • [Guillain-Barre syndrome and antibodies to ganglioside GM1. Case report].

    abstract::A sudden onset of the syndrome Guillain-Barré in 48-year-old woman presenting as an acute motor neuropathy was associated with antibodies against ganglioside GM1 detected by ELISA. The neurological examination revealed flaccid quadriplegia without affection of the sensory system, and the additional investigation showe...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Trisković I,Dimitrijević Lj,Rakocević-Stojanović V,Trikić R,Apostolski S

    更新日期:1996-07-01 00:00:00

  • [Results of the modification of antireflux subserosal and submucosal implantation of the ureter into the rectosigmoid urinary reservoir after total cystectomy].

    abstract:INTRODUCTION:Uretero-intestinal anastomisis has a large influence on derivation quality. OBJECTIVE:The aim of the study was to present the modified serous lined extramural Abol-Enein method of implantation of low quality ureter into the sigma-rectum pouch and comparison of the results with Le Duc implantation. METHOD...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1108491s

    authors: Stojković I,Ignjatović I,Bašić D

    更新日期:2011-07-01 00:00:00

  • [Nosocomial infections at Clinical Centre in Kragujevac--prevalence study].

    abstract:INTRODUCTION:Nosocomial infections (NIs) are a serious health problem in hospitals worldwide and are followed by a series of consequences, medical, judicial, ethical and economic. OBJECTIVE:The main aim of this study was to assess the magnitude of NIs at the Clinical Centre in Kragujevac. METHODS:A prevalence study o...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1006337i

    authors: IIić M,Marković-Denić L

    更新日期:2010-05-01 00:00:00

  • [Adhesion molecules in kidney diseases (part I)].

    abstract::Adhesive molecules are (glyco)proteins of the cellular membranes. All of them have their extramembranous, transmembranous and intracytoplasmatic parts. As receptor molecules, their extracellular parts bind the specific ligand. The ligand can be found on the surface of the other cell or in the extracellular matrix (bas...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:

    authors: Marković-Lipkovski J,Basta-Jovanović G,Smiljanić-Radotić K

    更新日期:1998-05-01 00:00:00

  • [Effect of heavy metals on symptoms of high-risk pregnancy].

    abstract::The authors studied the effect of working conditions and harmful organic solvents on the frequency of gynaecological diseases and menstrual disorders in 138 women. The experimental group consisted of 88 women exposed to evaporation and increased concentrations of organic solvents, and the control group was composed of...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Knezević M,Sulović V

    更新日期:1995-03-01 00:00:00

  • Non-Hodgkin lymphomas in childhood: how to move on?

    abstract::Non-Hodgkin lymphomas of childhood represent a diverse group of neoplasms with different clinical, pathological, immunophenotypical and genetic features. A vast majority of childhood non-Hodgkin lymphomas could be classified into one of the three major histological subgroups: mature B-cell neoplasms, lymphoblastic lym...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh1408498d

    authors: Dokmanović L,Rodić P,Krstovski N,Lazić J,Dragana J

    更新日期:2014-07-01 00:00:00

  • [Epilepsy, eponyms and patron saints (history of Western civilization)].

    abstract::From a historic point of view, epilepsy and its eponyms were in an ontogenetic symbiosis throughout their history. Epilepsy is a disease with a history of eponyms presenting the frame of mind of both streetwise as well as skilled "authors" about its origin and nature. From ancient times the names for epilepsy, archety...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 历史文章,杂志文章

    doi:

    authors: Janković SM,Sokić DV,Lević ZM,Susić V,Stojsavljević N,Drulović J

    更新日期:1996-05-01 00:00:00

  • [Problems with current hypertension definition in children].

    abstract::The Task Force data have added immeasurably to our understanding of the normal distribution of blood pressure in children. However, the manner in which arterial hypertension is defined in children is not without problems. The main problem is that the current definition of hypertension in children is not based on the e...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Peco-Antić A

    更新日期:2008-01-01 00:00:00

  • [Meningitis in neonates].

    abstract::The article deals with retrospective analysis of a seven-year autopsic material from the Institute of Pathologic Anatomy in Pristina. The aim of this analysis was to define the frequency, morphology and predisposing factors of neonatal meningitis. A good knowledge of morphology and predisposing factors in necessary in...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Mitić N

    更新日期:1991-03-01 00:00:00

  • [Peritoneal dialysis in the treatment of acute renal insufficiency].

    abstract::106 patients with acute renal failure (ARF) treated with peritoneal dialysis (PD) for the last 15 years (except for postrenal ARF treated only with HD, or ARF with conservative treatment) were analyzed. The commonest causes were sepsis (3), hemorrhagic fever (17) and complications of some internal or surgical disease ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Iknomovski J,Majster Z

    更新日期:1996-01-01 00:00:00

  • [Inhibition of angiogenesis in the cornea with amiloride].

    abstract:INTRODUCTION:For its transparency, avascularity and possibility of measurement of the new vessels ingrowth, cornea is a frequent model for angiogenesis research. New vessels are made in several phases: after the action of the stimulus, there is a localised fragmentation of the basal membrane and the extracellular matri...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Ignjatović Z,Nikolić Lj

    更新日期:1996-05-01 00:00:00

  • [St. Sava--the founder of hospital health service, social security (benefit) and medical education program in Serbia].

    abstract::The first written serbian medical records could be found in the Middle Ages (XIIIth century) when the serbian state was very well organized. St. Save was the son of Grand-Prince Stefan Nemanja (1171-1196), founder of the Serbian independent state and of a powerful dynasty that ruled Serbia for two centuries. At that t...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Pavlović B,Dragović S

    更新日期:1994-03-01 00:00:00

  • [Therapy of pouchitis after J-pouch ileoanal anastomosis (case report)].

    abstract::The ileal pouch-anal operation is the best procedure because it liberates the patient from ulcerative colitis i.e. from diseased mucosa of the large intestine. The ileal pouch forms a new reservoir for the storage of feces. Symptomatic pouch inflammation (pouchitis) appeared in 7-40% of the patients. The authors descr...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Stosić M,Cenić G,Stosić C

    更新日期:1994-09-01 00:00:00

  • [Natural history of supratentorial low-grade astrocytoma: case report].

    abstract::Low-grade astrocytomas comprise a group of primary brain neoplasms with relatively low anaplastic potential, although through time they tend to behave more aggressively. They have a very heterogeneous natural course and clinical behavior. This report presents a natural history of a patient with low grade astrocytoma. ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0612537r

    authors: Radulović D

    更新日期:2006-11-01 00:00:00

  • Compliance with hypertension guidelines in general practice in Slovenia.

    abstract:INTRODUCTION:Compliance with hypertension guidelines in clinical practice is generally poor, but there was no data about compliance with any guidelines in general practice in Slovenia. OBJECTIVE:Our aim was to find out whether general practitioners in Slovenia managed their hypertensive patients according to the natio...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0704191p

    authors: Petek-Ster M,Kersnik J,Svab I

    更新日期:2007-03-01 00:00:00

  • [Pendular stromal tumour of the stomach with dominant PDGFRA immunoexpression: case report and short literature review].

    abstract:INTRODUCTION:Gastrointestinal stromal tumours are most frequent mesenchimal tumours of the gastrointestinal tract that originate from Cajal's interstitial cells that are most frequently CD-117 positive. Stromal tumours of the stomach are the most frequent mesenchimal tumours of the gastrointestinal tract. Such tumours ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh1204216l

    authors: Latinčić S,Čolović N,Micev M,Čolović R

    更新日期:2012-03-01 00:00:00

  • [Therapeutic use of glucocorticoids and immunosuppressive agents].

    abstract::Pharmacotherapy of autoimmune thyroid disease (AITD) is complex. Apart from the replacement hormone therapy, antithyroid agents, beta adrenoceptor blockers and other drugs, in regard to the present symptoms, it also includes the administration of glucocorticoids and immunosuppressive agents. Physiological actions of g...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh05s1067g

    authors: Grbović L,Radenković M

    更新日期:2005-10-01 00:00:00

  • [Big intraocular foreign body: case report].

    abstract:INTRODUCTION:Penetrated injuries are most difficult injuries of the eye. Intraocular foreign body (IOFB) may lodge in any of the structures it encounters, from anterior chamber to the retina and choroid. Notable effects caused by foreign body injury include traumatic cataract, vitreous liquefaction, retinal and subreti...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Gaković A,Kovačević I,Biševac J,Radović B,Čubrilo K,Stefanović I

    更新日期:2013-07-01 00:00:00

  • [Computerized method for arm movement assessment in Parkinson's disease and cerebellar syndrome patients].

    abstract:BACKGROUND:In clinical setting, the symptoms of the impaired motor behavior in patients with different neurological diseases are identified by classical tests incorporated in clinical neurological examination. New computerized methods for objective motor assessment have been recently suggested in the literature. We dev...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Dordević O,Popović MB,Kostić V

    更新日期:2005-01-01 00:00:00

  • [Congestive heart failure in patients with chronic kidney disease].

    abstract::Cardiovascular disorders are the most frequent cause of death (46-60%) among patients with advanced chronic renal failure (CRF), and on dialysis treatment. Uremic cardiomyopathy is the basic pathophysiologic substrate, whereas ischemic heart disease (IHD) and anemia are the most important contributing factors. Associa...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh1412747p

    authors: Poskurica M,Petrović D

    更新日期:2014-11-01 00:00:00

  • [Treatment of esotropia with a high AC/A ratio].

    abstract::We have treated 55 children with accommodative esotropia and high AC/A ratio with progressive addition lenses, measured by heterophoria method. All of them wear full hyperopic refraction for distance and addition of +1.00 to 3.5 spheres for near vision. The minimal add that allowed the maximal reduction in the near de...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Risović D

    更新日期:2003-01-01 00:00:00

  • [Ancient Greek in modern language of medicine].

    abstract::In order to standardize language of medicine, it is essential to have a good command of ancient Greek and Latin. We cannot deny a huge impact of ancient Greek medicine on medical terminology. Compounds of Greek origin related to terms for organs, illnesses, inflammations, surgical procedures etc. have been listed as e...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0710606m

    authors: Marković V

    更新日期:2007-09-01 00:00:00

  • [Alveolar adenoma -- a rare lung tumour].

    abstract:INTRODUCTION:Alveolar adenoma belongs to the group of benign epithelial tumours. Histogenesis of alveolar adenoma is a combination of proliferation of alveolar pneumocytes and fibrous tissue originating from septal mesenchyma. CASE OUTLINE:A sixty-nine-year old female patient was hospitalizied for clinical examination...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0708461s

    authors: Stojsić J,Milenković B,Radojicić J,Percinkovski M

    更新日期:2007-07-01 00:00:00

  • Association of gene variants in TLR4 and IL-6 genes with Perthes disease.

    abstract:INTRODUCTION:Perthes disease is idiopathic avascular osteonecrosis of the hip in children, with unknown etiology. Inflammation is present during development of Perthes disease and it is known that this process influences bone remodeling. OBJECTIVE:Since genetic studies related to inflammation have not been performed i...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Srzentić S,Spasovski V,Spasovski D,Zivković Z,Matanović D,Bascarević Z,Supić ZT,Stojiljković M,Karan-Djurasević T,Stanković B,Pavlović S,Nikcević G,Vukasinović Z

    更新日期:2014-07-01 00:00:00

  • [Analysis of data on hemodialyzed patients for the development of a data base].

    abstract::Needs for state-of-the-art records on haemodialyzed patients implies abandoning of conventional paper work and development of a computer data base on haemodialyzed patients. Thus, data on haemodialyzed patients were analyzed. Since haemodialysis is a specific mode of treatment and differs from out-patient and in-patie...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Stosović M,Ostrić V,Ristić S,Stanojević M,Dimitrijević Z,Popović Z

    更新日期:1996-01-01 00:00:00

  • Preoperative administration of cephalosporins for elective caesarean delivery.

    abstract:INTRODUCTION:Antibiotic prophylaxis means administration of antibiotics in prevention of infections. OBJECTIVE:To investigate the efficacy of a single dose preoperative administration of ceftriaxone and cefazolin in the prevention of intra- and postoperative infections in the parturients without high risk of inflammat...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1010600g

    authors: Grujić Z,Popović J,Bogavac M,Grujić I

    更新日期:2010-09-01 00:00:00

  • Early intervention in first episode psychosis: hope for a better future.

    abstract::In the last two decades the clinical and research focus in psychotic disorders has shifted to first episode psychosis, early detection of the prodromal phase of psychosis and an effective integrated treatment model known as "Early Intervention". The first five years of psychosis that is described as a "critical period...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:

    authors: Goldner-Vukov M,Cupina DD,Moore LJ,Baba-Milkić N,Milovanović S

    更新日期:2007-11-01 00:00:00

  • Changing the structure of the hospitalized patients at the Psychiatric Clinic Vrapce.

    abstract:INTRODUCTION:Psychiatric treatment in developed countries has significantly changed in the last few decades, with a significant shortening of the duration of hospitalization. Numerous West European countries are undertaking health system reforms to improve treatment efficiency. OBJECTIVE:The aim of the study was to pr...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Bilić P,Ivanis A,Vidović D,Jukić V

    更新日期:2011-12-01 00:00:00

  • [Mesangium: interactions between mesangial cells and extracellular matrix].

    abstract::This is a survey of the recent data on glomerular mesangium. Besides its structural role as the main part of the capillary network, mesangial cells play a certain role in the formation and degradation of the extracellular matrix, in the spread and processing of circulating macromolecules, and in the regulation of glom...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:

    authors: Ivić M,Bogićević M,Stefanović V

    更新日期:1994-03-01 00:00:00

  • [Bronchial reactivity in chronic obstructive bronchitis].

    abstract::The frequency and the degree of bronchial hyperreactivity was investigated in 92 patients suffering from chronic obstructive bronchitis. Bronchial reactivity was examgned by the inhalator acetylcholine test, with the use of a 5 mg dose of acetylcholine, diluted in 1 ml of sodium-chloride solution. The pulmonary functi...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Drecun V

    更新日期:1994-11-01 00:00:00