Non-Hodgkin lymphomas in childhood: how to move on?

Abstract:

:Non-Hodgkin lymphomas of childhood represent a diverse group of neoplasms with different clinical, pathological, immunophenotypical and genetic features. A vast majority of childhood non-Hodgkin lymphomas could be classified into one of the three major histological subgroups: mature B-cell neoplasms, lymphoblastic lymphomas or anaplastic large cell lymphomas. Modern therapeutic strategies lead to cure in more than 80% of patients. Conversely, refractory diseases, as well as disease relapse convey a dismal prognosis. This fact requires much better stratification based on prognostic markers which would ideally recognize distinct groups of patients requiring different therapeutic regimens. Defining novel diagnostic and prognostic markers should improve diagnosis and prognosis as well as patient follow-up. It should also allow introduction of individually tailored treatment regimens in selected groups of patients with non-Hodgkin lymphomas, with the main goal of improving treatment results and decreasing short- and long-term complications.

journal_name

Srp Arh Celok Lek

authors

Dokmanović L,Rodić P,Krstovski N,Lazić J,Dragana J

doi

10.2298/sarh1408498d

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

498-504

issue

7-8

eissn

0370-8179

issn

2406-0895

journal_volume

142

pub_type

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