Abstract:
INTRODUCTION:Vascular remodelling is an adaptive process involving the adjustment of the structure and function of blood vessels to long-term changes in haemodynamic conditions. This process leads to structural alterations within vessel walls in different cardiovascular diseases, such as hypertension, atherosclerosis, and coarctation of the aorta. OBJECTIVE:We investigated the histochemical and immunocytochemical characteristics of morphological lesions in coronary atherosclerosis and coarctation of the aorta. METHOD:Twenty-one samples of atherosclerotically modified right coronary arteries, divided into 6 segments, were analysed. We also examined 10 samples of coarctation segments, excised during surgery. The segments were stained histochemically (using orcein and alcian blue-PAS), immunocytochemically (using alpha-smooth muscle actin-alpha-SMA, vimentin, desmin, myosin heavy chains-MHC, CD3, CD45, S-100, and Proliferating Cell Nuclear Antigen-PCNA), and for electron microscopy. RESULTS:The results of our study of morphological lesions in coronary atherosclerosis demonstrated initial functional and then, in the later stages of atherosclerosis, morphological, damage to the endothelium. The preatheroma stage revealed the presence of intimal dedifferentiation of smooth muscle cells, with the expression of vimentin and alpha-SMA, and the lack of expression of desmin. Along with these changes, a huge number of foam cells of variant origin were noticed. Some of them were CD68-immunoreactive while others were both vimentin- and S-100-immunoreactive. All examined samples of the coarctation of the aorta demonstrated the presence of dedifferentiated smooth muscle cells as well as a diminution in cell numbers, followed by apoptotic smooth muscle cells, and the absence of inflammatory cells. CONCLUSION:Some foam cells develop from monocyte-macrophage lineage (CD68-immunoreactive), while others originate from smooth muscle cells (vimentin and S-100-immunoreactive). Coarctation of the aorta is characterised by a diminution in cell numbers (apoptosis) as well as their dedifferentiation from contractile to synthetic phenotype.
journal_name
Srp Arh Celok Lekjournal_title
Srpski arhiv za celokupno lekarstvoauthors
Lacković V,Vuković Idoi
10.2298/sarh06s1009lsubject
Has Abstractpub_date
2006-05-01 00:00:00pages
9-16eissn
0370-8179issn
2406-0895journal_volume
134 Suppl 1pub_type
杂志文章abstract:BACKGROUND:In clinical setting, the symptoms of the impaired motor behavior in patients with different neurological diseases are identified by classical tests incorporated in clinical neurological examination. New computerized methods for objective motor assessment have been recently suggested in the literature. We dev...
journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 杂志文章
doi:
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 杂志文章,评审
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journal_title:Srpski arhiv za celokupno lekarstvo
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更新日期:2014-01-01 00:00:00
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 临床试验,杂志文章
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更新日期:2002-07-01 00:00:00
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
abstract::The roots of hospital foundation in Serbs date from the 12th century, when the hospitals in the monasteries Hilandar (1199) and Studenica (1207) were established. The "Town" Hospital of Belgrade was founded in 1841, which had the status of town and regional hospital until 1881. After that, it was transformed into a ge...
journal_title:Srpski arhiv za celokupno lekarstvo
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更新日期:2009-05-01 00:00:00
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journal_title:Srpski arhiv za celokupno lekarstvo
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更新日期:1992-03-01 00:00:00
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 杂志文章,评审
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更新日期:2005-05-01 00:00:00
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 临床试验,杂志文章
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更新日期:1999-09-01 00:00:00
abstract::Acalculia is an acquired disturbance of calculation that has several clinical expressions. Disturbances cna be aphasic and nonaphasic. Further division is into alexia and agraphia for numbers, anarithmetria and spatial acalculia. In addition to these manifestations due to focal cerebral lesions also diffuse lesions ca...
journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
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journal_title:Srpski arhiv za celokupno lekarstvo
pub_type: 杂志文章
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