Abstract：
:Search and disclosure of most adequate diagnostic criteria and prognostic indicators of disease represents one of the most difficult tasks in the understanding of any disease, which creates the way toward a more successful treatment and longer survival. The recent advances in research techniques that have helped refine the diagnostic work up and prognosis of myeloma include serum-free light chains, especially in oligosecretory myeloma, magnetic resonance and positron emission tomography in the diagnosis of bone diseases, cytogenetics and fluorescent in situ hibridization (FISH) technique to determine prognosis. The International Staging System and Durie/Salmon PLUS system are the current standards for staging myeloma. Newer risk stratification protocols are based on international staging system and chromosomal changes detected by conventional cytogenetics and FISH. These improved predictive risk stratification models have enabled the determination of prognosis in patients with myeloma which has a considerable influence on the choice of therapeutic algorism. Novel therapies enable a significant increase in achieving complete remission in a significant number of patients which also results in the definition of more precise criteria regarding the response to therapy. A firm and complete remission with a very good partial remission represent new categories defined by the international uniform criteria of response to therapy. This paper provides the current criteria for diagnosis, staging, risk stratification and response assessment of myeloma.
journal_name
Srp Arh Celok Lekjournal_title
Srpski arhiv za celokupno lekarstvoauthors
Djurdjević P,Andjelković N,Bila Jdoi
10.2298/sarh11s2095dsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
95-102eissn
0370-8179issn
2406-0895journal_volume
139 Suppl 2pub_type
杂志文章abstract：:The paper is aimed at illustrating the importance of nonspecific and specific bronchoprovokative tests for diagnosing allergic bronchial asthma by pathophysiologic mechanisms of hyperiritability of airways and making of specific "schok tissue". Besides we tried to explain these exeptional cases which we encounter in o...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:In 1993 the European Academy of Allergy and Clinical Immunology was the first official organization to recognize that sublingual administration could be “promising route” for allergic desensitization. A few years later, the World Health Organization recommended this therapy as “a viable alternative to the injection ro...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：
更新日期：2016-05-01 00:00:00
abstract：INTRODUCTION:Diabetes mellitus as a complex metabolic disease influences functioning of numerous organs. Chronic periodontitis is one of frequent diabetic complications. OBJECTIVE:The aim of this study was to compare the clinical effects of non-surgical periodontal therapy between diabetes mellitus type 2 patients (DM...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1312738m
更新日期：2013-11-01 00:00:00
abstract：:106 patients with acute renal failure (ARF) treated with peritoneal dialysis (PD) for the last 15 years (except for postrenal ARF treated only with HD, or ARF with conservative treatment) were analyzed. The commonest causes were sepsis (3), hemorrhagic fever (17) and complications of some internal or surgical disease ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Hanging is a form of ligature strangulation in which the force applied to the neck is derived from the gravitational drag of one's own body weight. A furrow-dessication is the most common form of ligature mark on the skin. The furrow is a postmortem phenomenon due to ligature pressure and it is more detectable as the ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1502093n
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:In 1993 the gene responsible for Huntington's disease (IT15) was isolated [5]. It was mapped to the tip of the short arm of chromosome 4 and within its coding sequence, near the 5' end, it contained a certain number of trinicleotide (CAG)n (cytosine-adenine-guanine) repeats (Figure 1). This gene codes for ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:The purpose of this study was to analyse, by immunomorphometry, megakaryocytopoiesis in patients with myelodysplatsic syndrome. The results revealed that, in spite of marked megakaryocyte hyperplasia, patients with myelodysplastic syndrome suffer from severe peripheral thrombocytopenia. Megakaryocytes in myelodisplast...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Causes of eyeball loss in patients over 15 years of age are analyzed, over the period from the beginning of 1966 to the end of 1987. Data from the files of the Ophtalmopathologic Laboratory, Department of Eye Diseases, UCC, Belgrade, were used. In the period of 22 years 2067 eyeballs were enucleated, the procedure bei...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:The ileal pouch-anal operation is the best procedure because it liberates the patient from ulcerative colitis i.e. from diseased mucosa of the large intestine. The ileal pouch forms a new reservoir for the storage of feces. Symptomatic pouch inflammation (pouchitis) appeared in 7-40% of the patients. The authors descr...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：INTRODUCTION:Penetrating injury is characterized by the existence of entry wound only, and it can be with or without an intraocular foreign body (IOFB). IOFB can lead to a mechanical injury of the eye and to cause infection or to manifest other toxic effects on intraocular structures. Iron and copper can dissolve and c...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1306371k
更新日期：2013-05-01 00:00:00
abstract：:Needs for state-of-the-art records on haemodialyzed patients implies abandoning of conventional paper work and development of a computer data base on haemodialyzed patients. Thus, data on haemodialyzed patients were analyzed. Since haemodialysis is a specific mode of treatment and differs from out-patient and in-patie...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:Alveolar adenoma belongs to the group of benign epithelial tumours. Histogenesis of alveolar adenoma is a combination of proliferation of alveolar pneumocytes and fibrous tissue originating from septal mesenchyma. CASE OUTLINE:A sixty-nine-year old female patient was hospitalizied for clinical examination...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0708461s
更新日期：2007-07-01 00:00:00
abstract：:Detrusor tunnelling is an extravesical surgical procedure of ureteral reimplantation. It is surely the least traumatic method of surgical correction of vesico-ureteral reflux because antireflux mechanism is achieved with minimal detrusor muscle dissection. This procedure simplifies implantation of dilated ureters, dou...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:Hemodynamic instability is a common occurrence during liver transplantation (LT). Hypotension and hemodynamic instability during graft reperfusion are most commonly consequences of the postreperfusion syndrome (PRS). CASE OUTLINE:In this report, we present a case of severe cardiovascular collapse leading ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1508467a
更新日期：2015-07-01 00:00:00
abstract：:Spleen abscess is not frequent in children. It may be caused by haematogenous seeding of the spleen with bacteria from primary septic focus; by direct spread of infection from adjacent structures, or by secondary infection in an area of the spleen damaged by infarction, trauma or parasitic infestation. A 13-year-old g...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:This review is a brief overview of recent advances in biology as well as in potential clinical application of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF). Biologically active rhGM-CSF is a recombinant human protein expressed in Escherichia coli. GM-CSF is produced by nontransformed (T...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：
更新日期：1993-08-01 00:00:00
abstract：:The first written serbian medical records could be found in the Middle Ages (XIIIth century) when the serbian state was very well organized. St. Save was the son of Grand-Prince Stefan Nemanja (1171-1196), founder of the Serbian independent state and of a powerful dynasty that ruled Serbia for two centuries. At that t...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 传,历史文章,杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Actual diagnostic sriteria are represented by a large spectar of data proposed by certain authors, so generally accepted protocole does not exist for similar clinical states i.e. asthmatic bronchitis, recurrent bronchitis and bronchial asthma in childhood, there is a different diagnostic terminology. Our clinical expe...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：INTRODUCTION:Diseases of the gastrointestinal system, and especially diseases of esophagus, are a rare cause of sudden unexpected death in any age group. Black esophagus is an acute necrotizing inflammation of the mucosa of the lower parts of esophagus, diffusely affecting its entire circumference. This inflammation co...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1402094n
更新日期：2014-01-01 00:00:00
abstract：INTRODUCTION:Nutritional abnormalities have one of the most important systematic effects on chronic obstructive pulmonary disease (COPD). A relationship between COPD and obesity has been observed and recognised. In COPD patients, beside changes in the total body weight, changes in body composition are also possible wit...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1106322c
更新日期：2011-05-01 00:00:00
abstract：:Solid and cystic-papillary tumour of the pancreas is a rare neoplasm. About 420 cases seem to have been reported as yet. It appears almost exclusively in young women, although it may appear in males in all ages. This is a tumour of benign or low malignant potential with vary rare invasion of surrounding tissues and or...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:Ataxia is defined as a disturbance which, quite independent of any motor weakness, alters direction and extent of voluntary movement and impairs the sustained voluntary of reflex muscle contraction necessary for maintaining postiue and equilibrium [1]. Since pathophysiological basis of cerebeller ataxia is still not c...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：Introduction:The anterior and middle superior alveolar nerve block was claimed to be unpredictably efficient for clinical application. Objective:The aim of this report was to establish the efficacy of the anterior and middle superior alveolar nerve block, applied with a computer-controlled injection system or a conven...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2016-09-01 00:00:00
abstract：:We describe a 51-year old-woman with haemorrhagic syndrome manifested as spontaneous bruising, and prolonged and abundant menstrual bleeding. She had hed these symptomes for six months prior to admission, but denied lifelong bleeding tendency. Gynaecological examination revealed a myomatouse uterus. Occasionally, the ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:Low-grade astrocytomas comprise a group of primary brain neoplasms with relatively low anaplastic potential, although through time they tend to behave more aggressively. They have a very heterogeneous natural course and clinical behavior. This report presents a natural history of a patient with low grade astrocytoma. ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0612537r
更新日期：2006-11-01 00:00:00
abstract：INTRODUCTION:Carotid endarterectomy is a safe and reliable surgical procedure to treat the narrowing of the internal carotid artery greater than 70%. One of the most serious complications of surgical wound after endarterectomy is an infection caused by methicillin-resistant Staphylococcus aureus (MRSA) which is accompa...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1104225p
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:Intramural haematoma (IMH) and penetrating aortic ulcers (PAU) are the frequent cause of acute aortic syndrome that is disclosed with a rising frequency due to the development of new diagnostic methods. Different symptoms contribute to clinical misdiagnosis, while changeable locations and unpersuasive diam...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1106380k
更新日期：2011-05-01 00:00:00
abstract：:Our results of surgery of developmental disorder of the hip (DDH) in older children and adolescents by using the combination of Selter's innominate osteotomy and osteotomy of the superior pubis ramus were presented in this paper, enclosing the period from 1993 to 1995. The study included 11 hips, i.e. 9 patients, aged...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh04s1023b
更新日期：2004-10-01 00:00:00
abstract：:The management of idiopathic nephrotic syndrome (INS) in children includes immunosuppressive and symptomatic treatment. The response to corticosteroid therapy is the best prognostic marker of the disease. The majority of children with INS (about 85%) are steroid-sensitive as they normalize proteinuria within 4 weeks o...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：10.2298/sarh0410352p
更新日期：2004-09-01 00:00:00
abstract：INTRODUCTION:Adenocarcinoma of the small bowel is a rare gastrointestinal neoplasm usually affecting the distal duodenum and proximal jejunum. Because of their rarity and poorly defined abdominal symptoms, a correct diagnosis is often delayed. CASE OUTLINE:We present a 43-year-old woman admitted at the Clinic for Endo...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1304232i
更新日期：2013-03-01 00:00:00
