[Adhesion molecules in kidney diseases (part I)].

Abstract:

:Adhesive molecules are (glyco)proteins of the cellular membranes. All of them have their extramembranous, transmembranous and intracytoplasmatic parts. As receptor molecules, their extracellular parts bind the specific ligand. The ligand can be found on the surface of the other cell or in the extracellular matrix (basal membranes). The following families of adhesion molecules are: cadherins, selectins, integrins and members of immunoglobuline supergene family. Different members of the same family could have different times (in ontogenesis, in adult form) and space distribution (in different tissues, different tissue structures). The contact between the cells and basal membranes with these molecules is important for cell division, maintaining the tissue architecture, polarization and function of cells, migration of cells, endo- and exo-cytosis as well as for maintaining the structure and function of basal membranes. As above stated all this is important in the occurrence morphogenesis, haemostasis, inflammation, malignant cell transformation and metastasis. This knowledge is important for the better understanding of renal diseases.

journal_name

Srp Arh Celok Lek

authors

Marković-Lipkovski J,Basta-Jovanović G,Smiljanić-Radotić K

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

192-6

issue

5-6

eissn

0370-8179

issn

2406-0895

journal_volume

126

pub_type

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