当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium.

pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium.

Abstract：

:In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, Ca2+ crosslinking and freeze-thawing (FT) cycle techniques were used to prepare sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel beads. The mixture solution of SA and PVA was firstly crosslinked with Ca2+ to form beads and then subjected to freezing-thawing cycles for further crosslinking. The crosslinking process was confirmed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The swelling and pH-sensitive properties of the beads were investigated, and the drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug. Results indicate that the bead was formed well and the encapsulation efficiency was greatly improved when the ratio of PVA to SA is 3:1. The swelling and degradation of the developed beads was influenced by pH of the test medium and PVA content. FT process enhanced drug entrapment efficiency, improved swelling behaviors and slowed release of drug from the dual crosslinked beads compared with pure SA beads crosslinked with Ca2+ ion alone, which provide a facile and effective method to improve the drug delivery system.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Hua S,Ma H,Li X,Yang H,Wang A

doi

10.1016/j.ijbiomac.2010.03.004

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

517-23

issue

5

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(10)00085-1

journal_volume

46

pub_type

杂志文章

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