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Cu(II) ion loading in silk fibroin scaffolds with silk I structure.

Abstract：

:Metal ions play important roles in the diverse biochemical reactions associated with many cell signalling pathways. The modification of biomaterials with metal ions may offer a promising approach to stimulate cellular activity for improving tissue regeneration. Here, copper ion loading as a potential therapeutic agent in silk fibroin (SF) scaffolds was investigated. Freezing-annealing was used to induce silk I crystallization for forming water-insoluble SF scaffolds. Cu(II) ions were entrapped into SF scaffolds with different ratios by forming silk I crystal networks when copper chloride dihydrate was less than 5.0 wt%, producing water-stable materials. Moreover, it was found that copper ion chelation further enhanced SF stability when a low amount copper chloride was loaded. Increasing copper chloride content weakened silk I crystallization and Cu(II) ion chelation, rendering SF scaffolds unstable in water. Above 5.0 wt% copper chloride dihydrate, silk I crystallization was prevented. Finally, silk I scaffold with 1.5 wt% copper chloride dihydrate showed the strongest water-stability and highest loading efficiency. The results provide valuable data for understanding the effect of metal ions in freezing-induced SF crystallization, and also offer options for preparing novel Cu(II)-functionalized SF scaffolds.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Hua J,You H,Li X,You R,Ma L

doi

10.1016/j.ijbiomac.2020.04.094

subject

Has Abstract

pub_date

2020-05-05 00:00:00

pages

275-281

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)32955-X

journal_volume

158

pub_type

杂志文章

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