Sustained seroconversion of chronic hepatitis B infection after stem cell transplantation.

Abstract:

:  We present an 18-yr-old adolescent with acute lymphocytic leukemia, who underwent peripheral blood SCT with serologically and histologically documented chronic hepatitis B infection. Prior and during the transplant process, lamivudine was administered orally and he underwent SCT with a twofold decrease in viral load at the time of transplant from his HLA full matched, HBV natural immune (anti-HBs and anti-HBc positive) donor. Successful engraftment was achieved and three months after SCT, HBV seroconversion was documented accompanied with an ALT flare. Chronic graft-versus-host disease coincided after the transplantation, and he has been on immunosuppressive treatment for 25 months with sustained HBV seroconversion. We assume that adoptive immunity transfer combined with antiviral treatment might also constitute sustained seroconversion in chronic HBV, besides the reported risk of reactivation.

journal_name

Pediatr Transplant

authors

Serap A,Funda O,Bengu K,Mehmet K,Nazan C,Rasit Y,Savas K

doi

10.1111/j.1399-3046.2009.01272.x

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

E92-5

issue

5

eissn

1397-3142

issn

1399-3046

pii

PTR1272

journal_volume

15

pub_type

杂志文章
  • Re-evaluation of the indications for liver transplantation in Wilson's disease based on the outcomes of patients referred to a transplant center.

    abstract::The aim of this study was to re-evaluate the indications and timing of LT for WD. From 2000 to 2009, eight patients with WD who had been referred to our institution for LT were enrolled in this study. The mean patient age was 15.9 yr (range, 7-37 yr). Four patients could not receive LT, because there were no available...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12085

    authors: Ohya Y,Okajima H,Honda M,Hayashida S,Suda H,Matsumoto S,Lee KJ,Yamamoto H,Takeichi T,Mitsubuchi H,Asonuma K,Endo F,Inomata Y

    更新日期:2013-06-01 00:00:00

  • Oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation: clinical outcomes in a context of specialized oral care using low-level laser therapy.

    abstract::OM is a painful inflammatory condition of the oral mucosa, derived from the toxic effects of chemotherapy and radiotherapy. High OM severity is frequently present in HSCT pediatric patients, who exhibit multiple painful ulcers that limit their mastication and swallowing, leading to poor nutritional status. Few studies...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12440

    authors: Eduardo Fde P,Bezinelli LM,de Carvalho DL,Lopes RM,Fernandes JF,Brumatti M,Vince CS,de Azambuja AM,Vogel C,Hamerschlak N,Correa L

    更新日期:2015-05-01 00:00:00

  • High depression rates among pediatric renal replacement therapy patients: A cross-sectional study.

    abstract::Depression is common in pediatric chronic kidney disease (CKD) patients. Depression is associated with inferior long-term outcomes. There is a paucity of studies that evaluate depression and possible associated factors in children and adolescents requiring renal replacement therapy (RRT). Cross-sectional study using C...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13591

    authors: Rodriguez Cuellar CI,García de la Puente S,Hernández Moraria J,Bojórquez Ochoa A,Filler G,Zaltzman Grishevich S

    更新日期:2019-12-01 00:00:00

  • Pediatric renal transplantation in the Nordic countries: a report of the Nordic Pediatric Renal Transplant Study Group.

    abstract::The Nordic Pediatric Renal Transplant Study Group was organized in 1994 to register and follow children under 16 years of age who receive renal allografts in the Nordic countries. It comprises all transplant centers in Scandinavia, four in Sweden, three in Denmark and one each in Norway and Finland. The following repo...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Tydén G,Berg U

    更新日期:1998-08-01 00:00:00

  • Successful medical treatment of EBV smooth muscle tumor in a renal transplant recipient.

    abstract::EBV is associated with various malignancies in patients with acquired or induced immune impairment. EBV-SMT is very uncommon in immunocompromised patients, and a kidney localization has been described only anecdotally. We report the case of a 17-yr-old kidney transplant recipient diagnosed as having an EBV-SMT inside ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01213.x

    authors: Belingheri M,Comoli P,Locatelli F,Baldanti F,Martina V,Giani M,Ferraresso M,Cro L,Edefonti A,Ghio L

    更新日期:2010-12-01 00:00:00

  • Varicella infection following vaccination in a pediatric kidney transplant recipient.

    abstract::Live viral vaccines have historically been avoided in children after solid organ transplantation. Multiple reports of safety and immunogenicity, largely in the pediatric liver transplant population, have led to a reconsideration of this recommendation. Here, we report the case of a 4-year-old boy who inadvertently rec...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13667

    authors: Bobrowski AE,Muller WJ

    更新日期:2020-06-01 00:00:00

  • Chronic neutrophilic leukemia, an extremely rare cause of neutrophilia in childhood: Cure with hematopoietic stem cell transplantation.

    abstract::CNL is a rare myeloproliferative disorder frequently seen in older adults. A significant proportion of patients show progression to AML. Here, we report the case of a patient with FA who was monitored for leukopenia but who developed leukocytosis during the follow-up and was diagnosed with CNL probably after an acquir...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13199

    authors: Uygun V,Daloğlu H,Öztürkmen S,Karasu G,Avcı Z,Yeşilipek A

    更新日期:2018-08-01 00:00:00

  • Long-term follow-up in adult living donors for combined liver/bowel transplant in pediatric recipients: a single center experience.

    abstract::Pediatric candidates for combined liver/bowel transplant (LBTx) experience a very high mortality on the cadaver waiting list. Our transplant center has successfully used adult living donors to treat pediatric candidates for LBTx. We report the long-term follow-up of this unique cohort of organ donors. The charts of si...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01501.x

    authors: Ghafari JL,Bhati C,John E,Tzvetanov IG,Testa G,Jeon H,Oberholzer J,Benedetti E

    更新日期:2011-06-01 00:00:00

  • Successful treatment of influenza A virus by oseltamivir in bone marrow transplant recipients.

    abstract::INFVA is an important cause of pulmonary infections in patients receiving BMT, and is associated with considerable morbidity and mortality for a readily preventable and treatable infection. Few studies have addressed the impact of the new neuraminidase inhibitors in the prognosis of influenza after BMT. The aim of thi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01114.x

    authors: Mellouli F,Ouederni M,Dhouib N,Hajkacem MA,Slim A,Bejaoui M

    更新日期:2010-03-01 00:00:00

  • Outcomes of pediatric living donor kidney transplantation: A single-center experience.

    abstract::Renal transplantation is the treatment of choice for children with ESRD offering advantages of improved survival, growth potential, cognitive development, and quality of life. The aim of our study was to compare the outcomes of LDKT vs DDKT performed in children at a single center. Retrospective chart review of pediat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12881

    authors: Pérez-Bertólez S,Barrero R,Fijo J,Alonso V,Ojha D,Fernández-Hurtado MÁ,Martínez J,León E,García-Merino F

    更新日期:2017-05-01 00:00:00

  • The use of porcine dermal collagen implants in assisting abdominal wall closure of pediatric renal transplant recipients with donor size discrepancy.

    abstract::Children may have kidneys transplanted from donors larger than themselves. Abdominal wall closure may be difficult, with risks of abdominal compartment syndrome and graft compromise. Meshes used to facilitate closure may cause dense intra-abdominal adhesions, making further surgery or peritoneal dialysis difficult. We...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00824.x

    authors: Pentlow A,Smart NJ,Richards SK,Inward CD,Morgan JD

    更新日期:2008-02-01 00:00:00

  • Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation.

    abstract::The clinical significance of parvovirus B19 infection in pediatric solid-organ and bone marrow transplanted patients is unclear. The overall prevalence of parvovirus B19 infection in these patients is about 1-2% during the first year after transplantation. The most common symptom is anemia, but leukopenia and thromboc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2001.00035.x

    authors: Broliden K

    更新日期:2001-10-01 00:00:00

  • Early hepatic arterial thrombosis in liver transplantation: Systemic intravenous alteplase as a potential rescue treatment after failed surgical revascularization.

    abstract::eHAT is one of the most dreaded post-LT complication. Treatment approaches include retransplantation, revascularization, or observation. Systemic thrombolytic therapy is used in pediatric patients with thromboembolic events. However, there is no previous study reporting on the use of systemic r-tPA to treat eHAT. The ...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13902

    authors: Feier FH,Melere MU,Trein CS,da Silva CS,Lucchese A,Horbe A,Tonet F,Ricachinevsky C,Ferreira CT,Chedid MF,Kalil AN

    更新日期:2020-10-27 00:00:00

  • Perioperative management in pediatric heart transplantation from 1988 to 2001: anesthetic experience in a single center.

    abstract::Pediatric cardiac transplantation is currently an accepted option for end-stage heart disease and congenital cardiac malformations. This report focuses on the anesthetic perioperative management in 12 yr. From 1988 to 2001 we performed 90 heart transplantations in 88 children, infants and neonates. The pediatric heart...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00155.x

    authors: Schindler E,Müller M,Akintürk H,Valeske K,Bauer J,Zickmann B,Hempelmann G

    更新日期:2004-06-01 00:00:00

  • Lung transplantation and survival in children with cystic fibrosis: solid statistics--flawed interpretation.

    abstract::In their provocative paper, "Lung transplantation and survival in children with cystic fibrosis," Liou and colleagues state that "Prolongation of life by means of lung transplantation should not be expected in children with cystic fibrosis. A prospective, randomized trial is needed to clarify whether and when patients...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00924.x

    authors: Sweet SC,Aurora P,Benden C,Wong JY,Goldfarb SB,Elidemir O,Woo MS,Mallory GB Jr,International Pediatric Lung Transplant Collaborative.

    更新日期:2008-03-01 00:00:00

  • Renal function following liver transplantation in children.

    abstract::The literature regarding the etiology and incidence of short and long-term renal functional impairment in pediatric liver allograft recipients was reviewed. Most of the reports include recipients receiving cyclosporine as the primary immunosuppressant. Using calculated glomerular filtration rate (cGFR), creatinine cle...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2005.00381.x

    authors: Fine RN

    更新日期:2005-10-01 00:00:00

  • The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients.

    abstract::SR-aGVHD remains a significant cause of morbidity and mortality in allogeneic HCT recipients. Alemtuzumab has been used with success in adult patients but has not been studied in the pediatric setting. To estimate the effectiveness of alemtuzumab for the treatment of SR-aGVHD in pediatric patients, we retrospectively ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12183

    authors: Khandelwal P,Lawrence J,Filipovich AH,Davies SM,Bleesing JJ,Jordan MB,Mehta P,Jodele S,Grimley MS,Kumar A,Myers K,Marsh RA

    更新日期:2014-02-01 00:00:00

  • Outcome of allogeneic hematopoietic stem cell transplantation for children with acute myelogenous leukemia in second complete remission: single center experience.

    abstract::We reviewed 26 consecutive patients with AML who were transplanted in second CR2 between 1994 and 2005. The most common conditioning regimen was CY and TBI. Median age at transplant was 8.9 yr (range 2.2-18.2). Nine patients received related donor, 16 patients received unrelated donors, and one patient received unrela...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01101.x

    authors: Ishaqi MK,Afzal S,Dupuis A,Doyle J,Gassas A

    更新日期:2009-12-01 00:00:00

  • Impact of pretransplant splenectomy on patients with beta-thalassemia major undergoing a matched-related allogeneic stem cell transplantation.

    abstract::Impact of pretransplant splenectomy in patients with beta-thalassemia major undergoing an allogeneic SCT has never been addressed. Twenty-seven class III patients (29 transplants) had a pretransplant splenectomy. The outcome of these 29 transplants was compared with 76 transplants in class III who did not have a splen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00953.x

    authors: Mathews V,George B,Lakshmi KM,Viswabandya A,John JM,Sitaram U,Daniel D,Chandy M,Srivastava A

    更新日期:2009-03-01 00:00:00

  • Successful liver retransplantation for recurrent hepatopulmonary syndrome.

    abstract::HPS is defined as arterial hypoxemia because of pulmonary vasodilation as a result of cirrhotic or non-cirrhotic portal hypertension. This report describes a teenager with HPS because of primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome requiring OLT. HPS resolved completely within three months of O...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00790.x

    authors: Rajwal SR,Davison SM,Prasad R,Brownlee K,McClean P

    更新日期:2007-12-01 00:00:00

  • Concomitant oral findings in children after cardiac transplant.

    abstract::Heart transplantations have been performed in the Centre for Paediatric Heart Surgery at the Justus Liebig University in Giessen (Germany) since 1988. For further consultation and therapy, some affected children subsequently present at the Polyclinic for Paediatric Dentistry. In all these cases problematic oral findin...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00429.x

    authors: Ansari F,Ferring V,Schulz-Weidner N,Wetzel WE

    更新日期:2006-03-01 00:00:00

  • Outcomes of transplantation in children with primary hepatic malignancy.

    abstract::HBL and HCC are the most common hepatic malignancies in children. The role of OLT in children with HCC is still a matter of debate. The aim of this study was to review our experience of OLT for HCC. Medical records of patients (<18 yr) who underwent OLT for HCC were reviewed and compared to children who underwent OLT ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00751.x

    authors: Beaunoyer M,Vanatta JM,Ogihara M,Strichartz D,Dahl G,Berquist WE,Castillo RO,Cox KL,Esquivel CO

    更新日期:2007-09-01 00:00:00

  • Lifesaving liver transplantation for multi-organ failure caused by Bacillus cereus food poisoning.

    abstract::Bacillus cereus is a spore-forming, gram-positive bacterium that causes food poisoning presenting with either emesis or diarrhea. Diarrhea is caused by proteinaceous enterotoxin complexes, mainly hemolysin BL, non-hemolytic enterotoxin (NHE), and cytotoxin K. In contrast, emesis is caused by the ingestion of the depsi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12378

    authors: Tschiedel E,Rath PM,Steinmann J,Becker H,Dietrich R,Paul A,Felderhoff-Müser U,Dohna-Schwake C

    更新日期:2015-02-01 00:00:00

  • Comparative outcome analysis of pediatric kidney transplant in posterior urethral valves children with or without pretransplant Mitrofanoff procedure.

    abstract:BACKGROUND:Urinary diversion using catheterizable channel among posterior urethral valve (PUV) patients may help to alleviate the functional concerns of the bladder on the allograft. Herein, we review our series of PUV patients undergoing renal transplants at a single institution to determine outcomes between those wit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13798

    authors: Rickard M,Chua ME,Zu'bi F,Dos Santos J,Koyle MA,Lorenzo AJ,Farhat WA

    更新日期:2020-12-01 00:00:00

  • The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease.

    abstract::We present the unique case of a pediatric patient who received chemotherapy for a diagnosis of CD, while mechanically supported with a Berlin EXCOR LVAD secondary to restrictive cardiomyopathy. A four-yr-old previously healthy male with restrictive cardiomyopathy required MCS after cardiac arrest but was diagnosed wit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12398

    authors: Thomas TO,Chandrakasan S,O'Brien M,Jefferies JL,Ryan TD,Wilmot I,Baker ML,Madueme PC,Morales D,Lorts A

    更新日期:2015-02-01 00:00:00

  • Low incidence of adverse events in outpatient pediatric renal allograft biopsies.

    abstract::In 1999, our center implemented a policy of outpatient protocol biopsies as standard practice for the clinical management of pediatric renal allograft recipients. In order to determine the safety of this procedure, we conducted a retrospective chart audit of all outpatient renal allograft biopsies performed at our cen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00659.x

    authors: Birk PE,Blydt-Hansen TD,Dart AB,Kaita LM,Proulx C,Taylor G

    更新日期:2007-03-01 00:00:00

  • Functional capacity after pediatric liver transplantation: a pilot study.

    abstract::The prospective cross-sectional study investigated the 6MWT performance in pediatric group of liver transplant recipients (6-17 yr, median post-transplantation time of 22 months) and compared to the normal values obtained in healthy children as well as evaluated the reproducibility of the 6MWT. We analyzed the relatio...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12318

    authors: Maria da Silva R,Brunow de Carvalho W,Johnston C,Borba de Castro M,Manta Ferreira I,Patti CL,Anthero de Azevedo R,Miziara Gonzalez A,Moura Linhares M,Augusto Salzedas-Netto A

    更新日期:2014-09-01 00:00:00

  • National risk factors and estimated costs for redo ureteroneocystostomy after pediatric renal transplant.

    abstract::Approximately 800 pediatric renal transplants are performed annually in the United States. VUR or obstruction may cause graft failure requiring redo ureteroneocystostomy. We examined possible risk factors and cost using the PHIS national database. We examined the PHIS for 8.5 yr to determine the association between re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12522

    authors: Godebu E,Palazzi K,Bush R,Marietti S,Chiang G

    更新日期:2015-08-01 00:00:00

  • Tracking of blood pressure and its impact on graft function in pediatric renal transplant patients.

    abstract::We studied tracking of BP and its impact on GFR in 44 PRTP followed for 56 months. Three months PT 77% had elevated SBP percentile. First year SBP and DBP correlated positively with final values (p < 0.0001, 0.0002, respectively). Pretransplant and three month PT SBP correlated positively (p = 0.02). At one yr, SBP an...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00753.x

    authors: Silverstein DM,Leblanc P,Hempe JM,Ramcharan T,Boudreaux JP

    更新日期:2007-12-01 00:00:00

  • Reduced ATG-F dosage for induction in pediatric renal transplantation: a single-center experience.

    abstract::Rabbit antithymocyte globulin (ATG-F) is an extensively used induction agent. To our knowledge, no study to date has assessed reduced ATG-F dosage in children undergoing renal transplantation. This was a retrospective analysis of pediatric renal recipients in the Department of Kidney Transplantation, The First Affilia...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12224

    authors: Shang W,Feng G,Gao S,Wang Z,Pang X,Li J,Liu L,Feng Y,Xie H,Zhang S,Qiao B

    更新日期:2014-05-01 00:00:00