Functional capacity after pediatric liver transplantation: a pilot study.

Abstract:

:The prospective cross-sectional study investigated the 6MWT performance in pediatric group of liver transplant recipients (6-17 yr, median post-transplantation time of 22 months) and compared to the normal values obtained in healthy children as well as evaluated the reproducibility of the 6MWT. We analyzed the relationship between walked distance and the 6MWw, distance walked × body weight) with the anthropometric, clinical, and pulmonary functions. In post-transplanted group, the average walked distance was significantly shorter compared with control (687 ± 80 m vs. 511 ± 72 m, p < 0.001). The calculated ICC coefficient confirmed the reproducibility among tests. The Pearson correlation revealed that only walked distance in the 6MWT was moderately correlated with tidal volume. Conversely, the 6MWw was significantly correlated with age, weight, height, BMI, FVC, PEF rate, and volume expiratory. According to multiple regression analysis, age, VE and FVC factors explained 80% of the variance in the 6MWw. In conclusion, the pediatric liver transplant recipients' performance in the 6MWT is significantly lower than the values for healthy children of the same age. Notably, the 6MWw may provide relevant information, constituting an additional parameter in the determination of functional capacity.

journal_name

Pediatr Transplant

authors

Maria da Silva R,Brunow de Carvalho W,Johnston C,Borba de Castro M,Manta Ferreira I,Patti CL,Anthero de Azevedo R,Miziara Gonzalez A,Moura Linhares M,Augusto Salzedas-Netto A

doi

10.1111/petr.12318

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

586-93

issue

6

eissn

1397-3142

issn

1399-3046

journal_volume

18

pub_type

杂志文章
  • Pleural disease in patients undergoing lung transplantation for cystic fibrosis.

    abstract::Cystic fibrosis (CF) is associated with varying degrees of pleural inflammatory reaction that occurs as a result of chronic pulmonary infections and intervention to pleural space. The amount of pleural reaction is associated with the difficulty involved when performing the pneumonectomy at the time of lung replacement...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Dosanjh A,Jones L,Yuh D,Robbins RC

    更新日期:1998-11-01 00:00:00

  • Ureterocystoplasty (bladder augmentation) with a solitary kidney.

    abstract::Children who develop end-stage renal disease (ESRD) as a result of obstructive uropathies require evaluation and treatment of associated bladder dysfunction to ensure a good outcome following renal transplantation. Bladder dynamics can often be optimized medically, although surgical intervention is occasionally necess...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.01078.x

    authors: Kurzrock EA,Butani L,Kakker SP,Perez RV,Lavjay Butani.

    更新日期:2002-06-01 00:00:00

  • Denying renal transplantation to an adolescent medical cannabis user: An ethical case study.

    abstract::Medical cannabis is now legal in over half of the United States. As more patients adopt this unconventional therapy, it is inevitable that potential transplant recipients will disclose their cannabis use during transplant evaluation. Transplant teams are tasked with the decision to utilize a pressure resource, often w...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13467

    authors: Ryan JE,Noeder M,Burke C,Stubblefield SC,Sulieman S,Miller EG

    更新日期:2019-08-01 00:00:00

  • Challenges for paediatric transplantation in Africa.

    abstract::Transplantation is the accepted mode of treatment for patients with end-stage organ disease affecting the heart, lungs, kidney, pancreas, liver and intestine. Long-term outcomes have significantly improved and the aim of management is no longer only long-term survival, but also focuses on quality of life especially in...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12333

    authors: Spearman CW,McCulloch MI

    更新日期:2014-11-01 00:00:00

  • Variation in resource utilization in liver transplantation at freestanding children's hospitals.

    abstract::We sought to examine the relationship between liver transplant-related total cost, patient outcome, and hospital resource utilization at freestanding children's hospitals. Using the PHIS database, a retrospective study of 374 patients that underwent liver transplantation at 15 freestanding children's hospitals from Ju...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12783

    authors: Minneman JA,Grijalva JL,LaQuaglia MJ,Kim HB,Rangel SJ,Vakili K

    更新日期:2016-11-01 00:00:00

  • A clinical description of children with solid organ transplants who present with feeding disorder.

    abstract::Pediatric solid organ transplant recipients have long-standing malnutrition concerns related to their pretransplant medical status. The targeted nutrition therapy utilized pre-, peri-, and post-transplantation may have the adverse effect of impeding normally developing feeding skills, particularly in very young childr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13389

    authors: Lerret SM,Erato G,Goday PS,Silverman AH

    更新日期:2019-05-01 00:00:00

  • Exploring the potential for online peer support mentorship: Perspectives of pediatric solid organ transplant patients.

    abstract:OBJECTIVE:Self-management for patients who have undergone solid organ transplantation is demanding and a challenge for adolescents transitioning into adult-oriented healthcare systems. This study explores whether adolescent and young adult solid organ transplant patients support the use of online peer support programs ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13900

    authors: Anthony SJ,Young K,Ghent E,Gold A,Martin K,Solomon M,Teoh CW,Stinson J

    更新日期:2020-11-01 00:00:00

  • Transplanting patients with a positive donor-specific crossmatch: a single center's perspective.

    abstract::An increasing number of individuals with end-stage renal disease have become sensitized to human leukocyte antigens (HLA). Sensitization can have a profound impact on the likelihood of obtaining a requisite negative crossmatch (-XM) with a potential donor. Technologic breakthroughs in our ability to diagnose antibody-...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00214.x

    authors: Montgomery RA,Zachary AA

    更新日期:2004-12-01 00:00:00

  • Effect of CYP3A5*1 expression on tacrolimus required dose for transplant pediatrics: A systematic review and meta-analysis.

    abstract::This systematic review was designed to find out optimal tacrolimus dose in pediatrics according to their CYP3A5*1 genotype by performing meta-analysis. PubMed, Scopus, ISI web of Science, ProQuest, Cochrane library, and clinicaltrail.gov were systematically searched to find studies in which tacrolimus dose and/or bloo...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13248

    authors: Hendijani F,Azarpira N,Kaviani M

    更新日期:2018-06-19 00:00:00

  • Out-of-reach obscure bleeding: single-balloon enteroscopy to diagnose and treat varices in hepaticojejunostomy after pediatric liver transplant.

    abstract::Obscure gastrointestinal (GI) bleeding is defined as bleeding from the GI tract that persists or recurs, with no obvious etiology, after esophagogastroduodenoscopy (EGD), colonoscopy, and radiologic evaluation of the small bowel. We present the case of a 17-yr-old girl who for two years had been suffering from recurre...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01425.x

    authors: Curcio G,Sciveres M,Mocciaro F,Riva S,Spada M,Tarantino I,Barresi L,Traina M

    更新日期:2012-05-01 00:00:00

  • Outcomes of Berlin Heart EXCOR® pediatric ventricular assist device support in patients with restrictive and hypertrophic cardiomyopathy.

    abstract::The outcomes of pediatric ventricular assist device support in patients with diastolic heart failure have not been well described. This study reviews the North American experience with Berlin Heart EXCOR® ventricular assist device implants in children with such physiology. The Berlin Heart clinical database was review...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13048

    authors: Su JA,Menteer J

    更新日期:2017-12-01 00:00:00

  • Liver transplantation for pediatric inherited metabolic disorders: Considerations for indications, complications, and perioperative management.

    abstract::LT is an effective therapeutic option for a variety of IEM. This approach can significantly improve the quality of life of patients who suffer from severe disease manifestations and/or life-threatening metabolic decompensations despite medical/dietary management. Due to the significant risks for systemic complications...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12741

    authors: Oishi K,Arnon R,Wasserstein MP,Diaz GA

    更新日期:2016-09-01 00:00:00

  • Outcomes of Pneumocystis jiroveci pneumonia infections in pediatric heart transplant recipients.

    abstract::PJP is known to cause significant morbidity and rarely death in immunosuppressed patients. The prevalence and outcomes of PJP in pediatric solid-organ transplant patients are not well established. This study utilizes data from the PHTS to establish the prevalence and outcome of PJP in pediatric heart transplant recipi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01589.x

    authors: Ng B,Dipchand A,Naftel D,Rusconi P,Boyle G,Zaoutis T,Edens RE

    更新日期:2011-12-01 00:00:00

  • Collecting duct carcinoma arising in association with BK nephropathy post-transplantation in a pediatric patient. A case report with immunohistochemical and in situ hybridization study.

    abstract::The development of malignancy in a renal transplant graft is an uncommon phenomenon. A renal neoplasm developing in the adult donor kidney of a pediatric transplant recipient has only rarely been reported. We report a case of collecting duct carcinoma arising in association with BK virus nephropathy in an adult living...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00855.x

    authors: Emerson LL,Carney HM,Layfield LJ,Sherbotie JR

    更新日期:2008-08-01 00:00:00

  • Neuroradiologic findings in children with renal transplantation under 5 years of age.

    abstract::Chronic renal failure (CRF) is known to have adverse effects on the neurodevelopmental outcome of affected children. Some of these effects can be ameliorated by transplantation (TX). The cause and nature of the underlying brain injury is not known. We performed a brain magnetic resonance imaging (MRI) study on a group...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2003.00125.x

    authors: Valanne L,Qvist E,Jalanko H,Holmberg C,Pihko H

    更新日期:2004-02-01 00:00:00

  • Use of a virtual community as a psychosocial support system in pediatric transplantation.

    abstract::Despite significant interest by pediatric transplant patients in meeting others who have undergone transplantation, geographic distances combined with their daily routines make this difficult. This mixed-method study describes the use of Zora, a Web-based virtual community designed to create a support system for these...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01271.x

    authors: Bers MU,Beals LM,Chau C,Satoh K,Blume ED,DeMaso DR,Gonzalez-Heydrich J

    更新日期:2010-03-01 00:00:00

  • Early hepatic arterial thrombosis in liver transplantation: Systemic intravenous alteplase as a potential rescue treatment after failed surgical revascularization.

    abstract::eHAT is one of the most dreaded post-LT complication. Treatment approaches include retransplantation, revascularization, or observation. Systemic thrombolytic therapy is used in pediatric patients with thromboembolic events. However, there is no previous study reporting on the use of systemic r-tPA to treat eHAT. The ...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13902

    authors: Feier FH,Melere MU,Trein CS,da Silva CS,Lucchese A,Horbe A,Tonet F,Ricachinevsky C,Ferreira CT,Chedid MF,Kalil AN

    更新日期:2020-10-27 00:00:00

  • Mycophenolate mofetil for treatment of steroid-refractory acute graft-versus-host disease after pediatric hematopoietic stem cell transplantation.

    abstract::A standard treatment is yet to be established for steroid-refractory acute aGVHD following HSCT. The effects of MMF have not been well studied in children with aGVHD. We evaluated the effectiveness of oral MMF in 14 children with steroid-refractory aGVHD (grade II in one patient, grade III to IV in 13 patients). The m...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12545

    authors: Inagaki J,Kodama Y,Fukano R,Noguchi M,Okamura J

    更新日期:2015-09-01 00:00:00

  • Post-transplant lymphoproliferative disorder in children: recent outcomes and response to dual rituximab/low-dose chemotherapy combination.

    abstract::PTLD is a major complication after transplantation. Treatment options for PTLD are not standardized, usually sequential, starting with reduction in immunosuppression. Recently, we have used a dual combination of rituximab and reduced dose chemotherapy (R/C) directly after failed RI. We retrospectively identified 30 pe...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01370.x

    authors: Gupta S,Fricker FJ,González-Peralta RP,Slayton WB,Schuler PM,Dharnidharka VR

    更新日期:2010-11-01 00:00:00

  • Intraoperative blood loss and transfusion during primary pediatric liver transplantation: A single-center experience.

    abstract::Children undergoing liver transplantation are at a significant risk for intraoperative hemorrhage and thrombotic complications, we aim to identify novel risk factors for massive intraoperative blood loss and transfusion in PLT recipients and describe its impact on graft survival and hospital LOS. We reviewed all prima...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13449

    authors: Villarreal JA,Yoeli D,Ackah RL,Sigireddi RR,Yoeli JK,Kueht ML,Galvan NTN,Cotton RT,Rana A,O'Mahony CA,Goss JA

    更新日期:2019-06-01 00:00:00

  • Significant morbidity associated with RSV infection in immunosuppressed children following liver transplantation: case report and discussion regarding need of routine prophylaxis.

    abstract::Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in infants and young children. In immunocompromised children, RSV infection poses a serious health threat with significantly increased and prolonged virus shedding and the development of severe respiratory disease. We report t...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00583.x

    authors: Blanchard SS,Gerrek M,Siegel C,Czinn SJ

    更新日期:2006-11-01 00:00:00

  • Renal retransplantation of children: is a policy 'first cadaver donor, then live donor' an acceptable option?

    abstract::Retransplantation is often a necessity for children with end-stage renal disease (ESRD), as kidney graft survival is still not infinite. If a suitable live donor is present, the current policy is to use the live donor first, in order to obtain excellent long-term outcome and to prevent human leucocyte antigen (HLA) se...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.00049.x

    authors: De Meester J,Smits JM,Offner G,Persijn GG

    更新日期:2001-06-01 00:00:00

  • Approaches to graft-vs-host disease.

    abstract::Graft-vs-host disease (GVHD) is one of the most difficult problems in stem cell transplantation. It is best considered in the context of the normal immune response. The role of the immune system is to identify and eliminate foreign antigens. In the case of GVHD, the antigens are minor histocompatibility antigens (mHA)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2005.00441.x

    authors: Antin JH

    更新日期:2005-12-01 00:00:00

  • Value of soluble adhesion molecules and plasma coagulation markers in assessing transplant coronary artery disease in pediatric heart transplant recipients.

    abstract:BACKGROUND:With an increasing number of heart transplantations (HTx) performed in children and an extended long-term survival of these patients, the importance of transplant coronary artery disease (TCAD) rises in this group of transplant recipients. Reliable serum markers for diagnosis or non-invasive monitoring of th...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00488.x

    authors: Hilgendorff A,Kraemer U,Afsharian M,Bauer J,Tillmanns H,Kemkes-Matthes B,Kreuder J,Hoelschermann H

    更新日期:2006-06-01 00:00:00

  • Pediatric Transplant Rating Instrument - a scale for the pretransplant psychiatric evaluation of pediatric organ transplant recipients.

    abstract::Although the majority of pediatric solid organ transplant centers in the United States employ psychosocial criteria to assess the suitability of potential transplant candidates, there are no standardized pretransplant psychosocial assessment measures. Assessment scales that have been developed were designed for adult ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00785.x

    authors: Fung E,Shaw RJ

    更新日期:2008-02-01 00:00:00

  • Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents.

    abstract::This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16), and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12213

    authors: Park M,Lee YH,Kang HR,Lee JW,Kang HJ,Park KD,Shin HY,Ahn HS,Baek HJ,Kook H,Hwang TJ,Lee JW,Chung NG,Cho B,Kim HK,Lee SH,Yoo KH,Sung KW,Koo HH,Koh KN,Im HJ,Seo JJ,Park JE,Lim YJ,Lyu CJ,Lee JM,Hah JO,K

    更新日期:2014-03-01 00:00:00

  • Ethical issues in pediatric face transplantation.

    abstract::Facial transplantation has become a reality in adult medicine. Children are subject to congenital craniofacial differences, disease-related, traumatic, or thermochemical craniofacial changes and might be suitable for face transplantation. This manuscript addresses unique ethical issues in considering potential pediatr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13032

    authors: Benghiac AG,Garrett JR,Carter BS

    更新日期:2017-11-01 00:00:00

  • Successful medical treatment of EBV smooth muscle tumor in a renal transplant recipient.

    abstract::EBV is associated with various malignancies in patients with acquired or induced immune impairment. EBV-SMT is very uncommon in immunocompromised patients, and a kidney localization has been described only anecdotally. We report the case of a 17-yr-old kidney transplant recipient diagnosed as having an EBV-SMT inside ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01213.x

    authors: Belingheri M,Comoli P,Locatelli F,Baldanti F,Martina V,Giani M,Ferraresso M,Cro L,Edefonti A,Ghio L

    更新日期:2010-12-01 00:00:00

  • Cognitive and emotional outcome after pediatric liver transplantation.

    abstract::The aim of the study was to evaluate the cognitive and emotional development after pediatric liver transplantation. A total of 21 patients, aged 4-16.9 yr (median 9.6 yr) were tested 1-9 yr (median 4.2 yr) after the transplantation. The pretransplant diagnoses included biliary atresia (eight patients), various metabol...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00081.x

    authors: Adebäck P,Nemeth A,Fischler B

    更新日期:2003-10-01 00:00:00

  • Efficacy and safety of three times daily dosing of tacrolimus in pediatric kidney transplantation patients: A single-center comparative study.

    abstract:BACKGROUND/AIM:Several PK studies have shown that most pediatric patients may require higher doses on a mg/kg basis compared to adults to attain similar therapeutic trough concentrations. The aim of this study was to compare the efficacy and safety of three times daily to twice a day dosing of tacrolimus in pediatric k...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13733

    authors: Alabdulkarim Z,Al-Jedai A,Alkortas D,Alhasan K,Devol E

    更新日期:2020-09-01 00:00:00