Abstract:
:There are many motivations for adding simultaneously acquired MR images to PET scanning. The most straight forward are, superior registration of MR and PET images, the addition of morphological detail when there is non-rigid motion and for pre-clinical studies simultaneous imaging could lead to a significant reduction in the time that animals are required to be anesthetised. In addition simultaneous MR has the potential to provide accurate motion correction for PET image reconstruction. For functional imaging simultaneous acquisition is required to assess the subject in the same physiological state, such as acute stroke studies. The elimination of the additional radiation associated with combining CT with PET, by providing anatomic detail with MR, would be a crucial advantage for cancer screening. Combining the two instruments necessitates some engineering tradeoffs, especially associated with the use of the highly developed photomultiplier tube (PMT) used for light amplification, because of its incompatibility with strong magnetic fields. Our approach is to provide a split in the magnet and gradients to locate the magnetic sensitive components, the PMTs, in regions of low magnetic field, leaving only the essential PET components, the scintillator blocks, in the strong magnetic field region. The crystals are coupled to the PMTs by extending the optical fibres. A further advantage accrues by moving the PET electronics out of the region seen by the MR radio-frequency (RF) and gradient coils as electromagnetic interference effects between the PET and MR systems, which could cause artefacts in either modality, are eliminated. Here we describe a preliminary evaluation of the system, which is essentially a microPET Focus-120 located in a 1T split magnet, and compare its performance to previous microPET instruments.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Hawkes RC,Fryer TD,Siegel S,Ansorge RE,Carpenter TAdoi
10.1177/153303461000900106subject
Has Abstractpub_date
2010-02-01 00:00:00pages
53-60issue
1eissn
1533-0346issn
1533-0338pii
c4304/c4305/Preliminary-Evaluation-of-a-combined-mjournal_volume
9pub_type
杂志文章abstract::We previously showed that microRNA-182 (miR-182) might promote cell proliferation and migration in triple-negative breast cancer (TNBC). This study aimed to investigate circular RNAs (circRNAs) that interact with miR-182 and play important roles in TNBC. Thirty patients with TNBC were enrolled. One pair of tumor and a...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820950827
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The biological function of deoxycytidine kinase in tumor is not yet clear, and there are a few studies relating to the correlation of deoxycytidine kinase gene with the occurrence and development of liver cancer. METHODS:The messenger RNA expression of deoxycytidine kinase was analyzed with the use of the U...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820934133
更新日期:2020-01-01 00:00:00
abstract::The 3-D transrectal ultrasound (TRUS)-guided prostate biopsy system is a novel device that allows precise needle placement in a template fashion. We evaluate its utility for prostate cancer (PCa) detection. A retrospective analysis was performed evaluating 68 prospective patients at the Duke Prostate Center who underw...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460900800202
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To evaluate 2 simultaneous integrated boost treatment planning techniques using helical tomotherapy for breast conserving therapy with regard to acute skin toxicity and dosimetry. METHODS:Thirty-two patients were studied. The original approach was for 16 patients and incorporated a directional block of the ips...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615574387
更新日期:2016-04-01 00:00:00
abstract::Histological differentiation is a major pathological criterion indicating the risk of tumor invasion and metastasis in patients with hepatocellular carcinoma. The degree of tumor differentiation is controlled by a complex interacting network of associated proteins. The principal aim of the present study is to identify...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034617732426
更新日期:2017-12-01 00:00:00
abstract::One of the most lethal carcinomas is pancreatic cancer. As standard treatment using chemotherapy and radiation has shown limited success, thermal regimens (cryotherapy or heat ablation) are emerging as viable alternatives. Although promising, our understanding of pancreatic cancer response to thermal ablation remains ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034616655658
更新日期:2017-08-01 00:00:00
abstract::A review of the literature on the current applications of breast magnetic resonance imaging (MRI) indications, their rationale and their place in diagnosis and management of breast cancer was given. Contrast-enhanced breast MRI is developing as a valuable adjunct to mammography and sonography. Its high sensitivity for...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/153303460400300602
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:There is mounting evidence that microRNAs play an important role in nasopharyngeal carcinoma, which is widely prevalent in South China and is the most prevalent metastatic cancer among head and neck cancers. Recently, it has been shown that miR-494 is involved in the progression and prognosis of nasopharynge...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033818809993
更新日期:2018-01-01 00:00:00
abstract::A fiber confocal back scattering micro-spectrometer (FCBS) was established, which combined fiber confocal microscopy with light scattering spectroscopy (LSS) for early diagnosis of the cancer cell at cellular level. An adherent monolayer human normal gastric epithelium line GES-1 and a carcinoma cell line NCI-N87 as w...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500222
更新日期:2011-10-01 00:00:00
abstract::Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is able to detect breast cancer with high sensitivity. Furthermore, this method provides functional information on tissue composition and vascularization. This study aims to identify the potential of DCE-MRI to predict distant metastasis in breast cancer p...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500266
更新日期:2012-12-01 00:00:00
abstract::Most experimental studies of electroporation focus on permeabilization of the outer cell membrane. Some experiments address delivery of ions and molecules into cells that should survive; others focus on efficient killing of the cells with minimal temperature rise. A basic method for quantifying electroporation effecti...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033818792491
更新日期:2018-01-01 00:00:00
abstract::Intraoperative MRI (iMRI) is used in glioma surgery mainly to determine the extent of resection, allowing surgeons to immediately continue resection in case of residual tumor tissue. The aim of this study is to report on the influence of the use of iMRI on the extent of resection and survival of patients with glioblas...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303461000900404
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:To evaluate a method for reducing metal artifacts, arising from dental fillings, on cone-beam computed tomography images. MATERIALS AND METHODS:A projection interpolation algorithm is applied to cone-beam computed tomography images containing metal artifacts from dental fillings. This technique involves identi...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615618319
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To investigate the role of intensity-modulated proton therapy (IMPT) for hepatocellular carcinoma (HCC) patients to be treated with stereotactic body radiation therapy (SBRT) in a risk-adapted dose prescription regimen. METHODS:A cohort of 30 patients was retrospectively selected as "at-risk" of dose de-escala...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820980412
更新日期:2020-01-01 00:00:00
abstract::Targeted immunotherapy using dendritic cell vaccine has been employed for the treatment of solid tumors. Topical 5-aminolevulinic acid-mediated photodynamic therapy, an established approach for topical cancers, can induce an effective antitumor immune response. We have previously shown that 5-aminolevulinic acid-media...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033818785275
更新日期:2018-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the most aggressive type of gastrointestinal tumor, with a high rate of mortality. However, identifying biomarkers for the treatment of HCC remains to be developed. We aimed to determine whether cell division cycle 25C (CDC25C) could be used as a novel diagnostic and therapeutic bioma...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820967474
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To investigate the application value of apparent diffusion coefficient value in the pathological type, histologic grade, and presence of lymph node metastases of esophageal carcinoma. MATERIALS AND METHODS:Eighty-six patients with pathologically confirmed esophageal carcinoma were divided into different grou...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033819892254
更新日期:2019-01-01 00:00:00
abstract::Since "Warburg effect" has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs' energy metabolic role in chemoresist...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
doi:10.1177/1533033818805997
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Recent studies have confirmed that immune-associated genes perform a crucial function in recurrence and metastasis of thyroid carcinoma. A reliable immune-related prognostic signature for patients with thyroid cancer is needed. This study constructed a novel immune-related prognostic signature for thyroid ca...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820935860
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The incidence of colorectal cancer is increasing every year, and autophagy may be related closely to the pathogenesis of colorectal cancer. Autophagy is a natural catabolic mechanism that allows the degradation of cellular components in eukaryotic cells. However, autophagy plays a dual role in tumorigenesis. ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820984177
更新日期:2020-01-01 00:00:00
abstract::Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemotherapeutic drugs. The efficiency of electrochemotherapy strongly depends on the local electric field distribution inside the targ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460800700507
更新日期:2008-10-01 00:00:00
abstract:INTRODUCTION:Rectal cancer ranks as the eighth in cancer-related morbidity and the tenth in the cancer-related mortality. A few studies have explored several biomarkers for colorectal cancer. However, there is still a great need for us to excavate novel biomarkers with effective and efficient diagnostic and prognostic ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820973270
更新日期:2020-01-01 00:00:00
abstract::The aim of this retrospective study is to evaluate our therapeutic results in patients with paranasal sinus (PNS) or nasal cavity (NC) malignancies treated with robotic stereotactic radiosurgery (SRS). Between August 2007 and October 2008, 27 patients with PNS or NC tumors were treated in our department using SRS. Med...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrtexpress.2013.600264
更新日期:2014-10-01 00:00:00
abstract::The purpose of this research is to establish a process of irradiating mice using the Gamma Knife as a versatile system for small animal irradiation and to validate accurate intracranial and extracranial dose delivery using this system. A stereotactic immobilization device was developed for small animals for the Gamma ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034616658394
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:Osteosarcoma is the most common primary tumor of bone, although some molecular markers have been identified, the detailed molecular mechanisms underlying osteosarcoma are currently not fully understood. In the present study, we attempted to identify the potential key genes and pathways in osteosarcoma usin...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820965605
更新日期:2020-01-01 00:00:00
abstract::Optical mammography is one of several new techniques for breast cancer detection and characterization presently under development for clinical use that provide information other than morphologic, in particular on the biochemical and metabolic state of normal and diseased tissue. In breast tissue, scattering of red to ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460500400503
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:Nasopharyngeal carcinoma is highly endemic in Southeast China. Circulating tumor cell is an important biomarker in the prognosis of variety kinds of cancers. Overexpression of fibronectin 1 was observed in variety kinds of malignancies and may contribute to progress and metastasis of the cancers. The current ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820909911
更新日期:2020-01-01 00:00:00
abstract::The accurate characterization and description of the vascular network of a cancer lesion is of paramount importance in clinical practice and cancer research in order to improve diagnostic accuracy or to assess the effectiveness of a treatment. The aim of this study was to show the effectiveness of liposomes as an ultr...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrtexpress.2013.600272
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To develop and evaluate an automatic intensity-modulated radiation therapy (IMRT) program for cervical cancer, including a Convolution Neural Network (CNN)-based prediction model and an automated optimization strategy. METHODS:A CNN deep learning model was trained to predict a patient-specify set of IMRT objec...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820957002
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:A meta-analysis was conducted to evaluate the diagnostic performance of contrast-enhanced ultrasonography using the contrast agent SonoVue to differentiate benign from malignant breast lesions. METHOD:A comprehensive search of the literature was performed using the Embase, PubMed, and Web of Science databases ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820971583
更新日期:2020-01-01 00:00:00