Abstract：
:In the present study, we examined the effect of amphotericin B on larval stages (miracidia and primary sporocyst) of the helminth Schistosoma mansoni, the causative agent of human schistosomiasis. Amphotericin B (AmB) is a polyene macrolide that disturbs the function of the cell membrane; it is widely used as prophylactic antimycotic agent in in vitro culture. We show for the first time that S. mansoni miracidia infectivity is considerably reduced after AmB treatment. Moreover we demonstrate that AmB does not affect the development, growth, viability, and behavior of miracidia and primary sporocysts. Our data indicate that AmB effects on S. mansoni sporocyst prevalence are linked to the oxidative properties of AmB. These may alter the capacity of sporocysts to respond to the oxidative stress generated by the snail immune defence system.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Moné Y,Mitta G,Duval D,Gourbal BEdoi
10.1016/j.exppara.2009.12.024subject
Has Abstractpub_date
2010-06-01 00:00:00pages
70-5issue
2eissn
0014-4894issn
1090-2449pii
S0014-4894(10)00003-2journal_volume
125pub_type
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