Abstract：
:In this work, direct DNA damage induced by low-energy electrons (<5 keV) is simulated using Monte Carlo methods, and the resulting yield of various strand breaks and base damages in cellular environment is presented. The simulation is based on a new inelastic cross section for the production of electron track structure in liquid water, and on ionization cross sections of DNA bases to generate base radical. Especially, a systematic approach of simulating detailed base damage is suggested. This approach includes improvement of a volume model of DNA, generation of the DNA base sequence, conversion of ionization events in liquid water at hit site to the ionization interaction of electrons with DNA bases and development of an algorithm to convert a base radical to a damage. The results obtained in terms of strand breaks are compared with those of experiments and other theoretical calculations, and good agreement was obtained. The yield of detailed base damages and clustered DNA damages caused by the combination of various strand breaks and base damages is presented, and the corresponding distribution characteristics are analyzed. The influence of the relative content of base pairs A-T and G-C in a DNA segment on the yield of both strand breaks and base damages is also explored. The present work provides fundamental information on DNA damage and represents the first effort toward the goal of obtaining the spectrum of clustered DNA damage including detailed base damages, for the mechanistic interpretation and prediction of radiation effects.
journal_name
Radiat Environ Biophysjournal_title
Radiation and environmental biophysicsauthors
Zhang L,Tan Zdoi
10.1007/s00411-009-0262-8subject
Has Abstractpub_date
2010-03-01 00:00:00pages
15-26issue
1eissn
0301-634Xissn
1432-2099journal_volume
49pub_type
杂志文章abstract：:It has generally been assumed that the neutron and γ-ray absorbed doses in the data from the life span study (LSS) of the Japanese A-bomb survivors are too highly correlated for an independent separation of the all solid cancer risks due to neutrons and due to γ-rays. However, with the release of the most recent data ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-012-0445-6
更新日期：2013-03-01 00:00:00
abstract：:The work reported here was originally motivated by a discussion of Monte Carlo computer codes for electron transport in water given in Report No. 130 by the National Council on Radiation Protection and Measurements (NCRP). It was pointed out (correctly) that a published depth-dose distribution calculated by the Oak Ri...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-003-0201-z
更新日期：2003-10-01 00:00:00
abstract：:The main target of this work is to examine blood clearance and external exposure for 177Lu-DOTATATE compared with new emerging 177Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq 177Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq 177Lu-PSMA. Dose ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-017-0721-6
更新日期：2018-03-01 00:00:00
abstract：:Those working in interventional cardiology are exposed to varying radiation doses during diagnostic and interventional procedures. The work presented in this paper aimed to monitor the effective doses received by different categories of medical staff members practicing interventional cardiology procedures including se...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-020-00862-x
更新日期：2020-11-01 00:00:00
abstract：:To evaluate the dose distributions of an electron microbeam and to help optimization of its design, the condensed-history (CH) Monte Carlo simulation algorithm implemented in the Geant4 toolkit was selected as an alternative to the conventionally used analog algorithm. Compared to the analog algorithm, the CH algorith...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-006-0027-6
更新日期：2006-03-01 00:00:00
abstract：:For studies on cell membranes, mice were exposed to mixed neutron + gamma reactor-radiation in the range of total doses from 0.5 to 4.5 Gy. Changes in functional activity of plasma membranes of erythrocytes, platelets, and lymphocytes were followed by a lectin-binding technique at various intervals afterwards. The amo...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01407598
更新日期：1984-01-01 00:00:00
abstract：:Mouse spermatogonial germ cells are highly sensitive to ionizing radiation. Lithium salts are reported to stimulate the postirradiation recovery of hematopoietic marrow cells. We have, therefore, examined whether administered lithium chloride (LiCl) would also be able to protect the mouse germinal cells against radiat...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s004110050063
更新日期：1997-06-01 00:00:00
abstract：:The TEL1 gene from Saccharomyces cerevisiae has been shown to be the closest sequence homologue to ATM, the gene mutated in ataxia-telangiectasia (A-T) patients. Functional homology shared between the ATM and Tell proteins has recently been demonstrated based on heterologous expression of the TEL1 gene in human cells ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-001-0125-4
更新日期：2001-12-01 00:00:00
abstract：:In the process of developing a new dosimetry system for atomic bomb survivors in Hiroshima and Nagasaki (DS02), an intercomparison study between (152)Eu and (36)Cl measurements was proposed, to reconcile the discrepancy previously observed in the Hiroshima data between measurements and calculations of thermal neutron ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-008-0166-z
更新日期：2008-07-01 00:00:00
abstract：:The aim of this study is to investigate if 1,800 MHz radiofrequency electromagnetic fields (RF-EMF) can induce reactive oxygen species (ROS) release and/or changes in heat shock protein 70 (Hsp70) expression in human blood cells, using different exposure and co-exposure conditions. Human umbilical cord blood-derived m...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-006-0038-3
更新日期：2006-05-01 00:00:00
abstract：:The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of (137)Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l(-1). Ingestion started in parent animals before mating, and (137)Cs intake and i...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-010-0267-3
更新日期：2010-05-01 00:00:00
abstract：:Low-dose ionizing radiation (IR) responses remain an unresolved issue in radiation biology and risk assessment. Accurate knowledge of low-dose responses is important for estimation of normal tissue risk in cancer radiotherapy or health risks from occupational or hazard exposure. Cellular responses to low-dose IR appea...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-020-00854-x
更新日期：2020-08-01 00:00:00
abstract：:Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acti...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-005-0006-3
更新日期：2005-10-01 00:00:00
abstract：:Sustained pain relief following radon spa therapy in patients suffering from chronic painful diseases has been well described. But still, the underlying mechanisms are not fully understood. We conducted the prospective and explorative RAD-ON01 study which included 103 patients who suffered from chronic painful musculo...
journal_title：Radiation and environmental biophysics
pub_type： 临床试验,杂志文章
doi：10.1007/s00411-018-0768-z
更新日期：2019-03-01 00:00:00
abstract：:Growth rates and cell diameters were determined from 12 species of plant roots exposed to a 60-Hertz (Hz) electric field of 360 Volts per meter (V/m) in an aqueous inorganic nutrient medium [conductivity: 0.07-0.09 Siemens per meter (S/m)]. The degree of growth depression ranged from zero to nearly 100 percent of cont...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01210937
更新日期：1985-01-01 00:00:00
abstract：:The Goiânia accident, Brazil, was used as an opportunity to quantify the contributions of different mechanisms, in particular mass loading, leading to caesium uptake by leafy vegetables in a semi-urban environment contaminated with 137Cs. Soil splash contributions of 70-90% were quantified for lettuce and 50-60% for g...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01210458
更新日期：1994-01-01 00:00:00
abstract：:At five stages of gestation, mice were exposed dorsally to ultrasonic irradiation at 1 W/cm2 (spatial and temporal average), 2 MHz, and 34 and 37 degrees C (temperature at beginning of exposure). The results indicated that ultrasonic exposure up to at least 100 s is not hazardous to a pregnant mouse or its offspring i...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323651
更新日期：1980-01-01 00:00:00
abstract：:Total body Irradiation (TBI) is often used for conditioning, prior to bone marrow transplantation. Doses of 8-14 Gy in 1-8 fractions over 1-4 days are administered using low dose rate external beam radiotherapy (EBRT). When necessary, consolidation EBRT using conventional doses, fractionation and dose rate is given. T...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-009-0238-8
更新日期：2009-11-01 00:00:00
abstract：:A mathematical model which simulates the observed dose-effect relationships for fish eggs exposed to chronic irradiation is presented. The model assumes that the exposed fish eggs may exist in one of the following states: normally developing, reversibly damaged, and lethally damaged. Reversible damages may be recovere...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-006-0058-z
更新日期：2006-09-01 00:00:00
abstract：:Microwave irradiation has been shown to decrease the input resistance of snail neurons. In this study, we examined the role of extracellular calcium in triggering the microwave-induced enhancement of membrane conductance. Two sets of experiments were conducted. In the first set, nerve cells were superfused using Ringe...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01229821
更新日期：1985-01-01 00:00:00
abstract：:Four different thiol reagents: p-chloromercuribenzoic acid (pCMB), mercuric chloride (HgCl2), N-ethylmaleimide (NEM), and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) were employed as agents modifying the transport of a hydrophilic and hydrophobic non-electrolyte spin labels: 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-o...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01323760
更新日期：1983-01-01 00:00:00
abstract：:In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-012-0401-5
更新日期：2012-05-01 00:00:00
abstract：:Several proteins are known to form foci at DNA sites damaged by ionizing radiation. We study DNA damage response by immunofluorescence microscopy after microirradiation of cells with energetic ions. By using microirradiation, it is possible to irradiate different regions on a single dish at different time-points and t...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-008-0181-0
更新日期：2008-11-01 00:00:00
abstract：:Activity catalysing double-strand DNA recombination has been investigated in human tumour cell lines using an in vitro assay in which nuclear extracts from tumour cells are used to catalyse homologous recombination between deletion plasmids. The cell lines investigated showed comparable constitutive levels of recombin...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s004110050056
更新日期：1997-02-01 00:00:00
abstract：:In this work, direct DNA damage induced by low-energy electrons (sub-keV) is simulated using a Monte Carlo method. The characteristics of the present simulation are to consider the new mechanism of DNA damage due to dissociative electron attachment (DEA) and to allow determining damage to specific bases (i.e., adenine...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-016-0681-2
更新日期：2017-03-01 00:00:00
abstract：:Ehrlich ascites tumour cells were irradiated with negative pions at different positions in the plateau and the peak of the depth absorbed dose curve. Dose-survival curves for immediate testing of the viability of the cells are given and are compared with other types of radiations in use for therapy. From the data obta...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01358286
更新日期：1979-08-10 00:00:00
abstract：:More accurate reconstruction of the radioactive contamination of the Techa River system in 1949-1951 has been made on the basis of refined data on the amounts and the rate of discharge of radionuclides into the Techa River from the Mayak Production Association; this has led to the development of a modified Techa River...
journal_title：Radiation and environmental biophysics
pub_type： 历史文章,杂志文章
doi：10.1007/s00411-012-0414-0
更新日期：2012-11-01 00:00:00
abstract：:The rate constants for the photodynamic inactivation of hen egg-white lysozyme at different temperatures were studied. Arrhenius plots of the methylene blue sensitized photo-inactivation of lysozyme gave an experimental activation energy of 7.5 kcal/mol. The rate constants for the photodynamic inactivation of lysozyme...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/BF01326898
更新日期：1979-02-23 00:00:00
abstract：:In this study, temporal variations of indoor radon concentrations in Bulgaria were investigated. The radon concentrations were measured by nuclear track detectors as part of the Bulgarian National Survey, performed in the dwellings of 28 regional districts. The detectors were exposed through a year in two consecutive ...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-019-00789-y
更新日期：2019-08-01 00:00:00
abstract：:Combined action of irradiation (IR), shear stress, and high blood pressure is well recognized to induce damage to vasculature, while data on pathological effects of IR in large peripheral vessels with low blood pressure are scarce. The purpose of the present study was hence to investigate time- and dose-dependent effe...
journal_title：Radiation and environmental biophysics
pub_type： 杂志文章
doi：10.1007/s00411-013-0492-7
更新日期：2014-03-01 00:00:00
