Abstract:
:Agouti-related protein (AGRP) is an orexigenic peptide secreted from the arcuate nucleus (ARC) of the hypothalamus. AGRP increases food intake and plays a role in energy balance, adiposity, weight gain, and growth-hormone release. The objective of the current study was to examine the effects of running exercise on resting hepatic, fundus, and pancreas AGRP mRNA expression, as well as liver glycogen and ATP contents, using a rat model. Twenty adult male Wistar rats (12-14 wk old, 200-220 g) were randomly assigned to control (n = 10) and training (n = 10) groups. The training group was exercised for 8 wk on a motor-driven treadmill (26 m/min, 0% grade, 60 min, 5 d/wk). Twenty-four hours before sacrifice the rats were further divided into fed control (FEC), fed trained (FET), fasted control (FAC), and fasted trained (FAT) groups. The liver, fundus, and pancreas were excised and frozen in liquid nitrogen for later analysis. Results demonstrated that 8 wk of treadmill exercise reduced hepatic but not fundus and pancreatic AGRP expression and enhanced glycogen and ATP concentrations (p < .001) in trained-rat liver, whereas fasting lowered liver glycogen and ATP levels and increased hepatic AGRP mRNA expression in nonexercising controls. Data indicate that both treadmill-exercise-induced decrease and fast-induced increase in rat liver AGRP expression might depend on liver glycogen content as an important source for energy provision.
journal_name
Int J Sport Nutr Exerc Metabauthors
Ghanbari-Niaki A,Fathi R,Kakhak SA,Farshidi Z,Barmaki S,Rahbarizadeh F,Kraemer RRdoi
10.1123/ijsnem.19.5.473subject
Has Abstractpub_date
2009-10-01 00:00:00pages
473-84issue
5eissn
1526-484Xissn
1543-2742journal_volume
19pub_type
杂志文章abstract:PURPOSE:The purpose of this study was to investigate the effect of acute and 4-week Rhodiola rosea intake on physical capacity, muscle strength, speed of limb movement, reaction time, and attention. METHODS: PHASE I:A double blind placebo-controlled randomized study (n= 24) was performed, consisting of 2 sessions (2 ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2010-12-01 00:00:00