The aging cardiovascular system: changes in autonomic function at rest and in response to exercise.

Abstract:

:Tonic vagal modulation of cardiac period (R-R interval) decreases with advancing age, but is greater in middle-aged and older adults who habitually perform aerobic exercise compared with their sedentary peers. Cardiovagal baroreflex sensitivity also declines markedly with age in sedentary adults but only 50% as much in regularly exercising adults. In previously sedentary middle-aged and older adults, a 3-month program of moderate aerobic exercise increases cardiovagal baroreflex sensitivity by 25%. Tonic (basal) sympathetic nervous system (SNS) activity increases with advancing age in both sedentary and habitually exercising adults. Despite this, SNS beta-adrenergic support of energy metabolism (resting metabolic rate--RMR) declines with age in sedentary individuals. However, SNS beta-adrenergic support of RMR is maintained with age in endurance exercise-trained adults and therefore is much greater in middle-aged and older individuals who exercise regularly compared with their sedentary peers. Thus, regular aerobic (endurance) exercise modulates selective age-associated impairments in autonomic nervous system-physiological function.

authors

Seals DR,Monahan KD,Bell C,Tanaka H,Jones PP

doi

10.1123/ijsnem.11.s1.s189

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

S189-95

eissn

1526-484X

issn

1543-2742

journal_volume

11 Suppl

pub_type

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