Abstract:
AIMS/OBJECTIVES:To evaluate the current literature via systematic review to ascertain whether amino acids/vitamins provide any influence on musculotendinous healing and if so, by which physiological mechanisms. METHODS:EBSCO, PubMed, ScienceDirect, Embase Classic/Embase, and MEDLINE were searched using terms including "vitamins," "amino acids," "healing," "muscle," and "tendon." The primary search had 479 citations, of which 466 were excluded predominantly due to nonrandomized design. Randomized human and animal studies investigating all supplement types/forms of administration were included. Critical appraisal of internal validity was assessed using the Cochrane risk of Bias Tool or the Systematic Review Centre for Laboratory Animal Experimentation Risk of Bias Tool for human and animal studies, respectively. Two reviewers performed duel data extraction. RESULTS:Twelve studies met criteria for inclusion: eight examined tendon healing and four examined muscle healing. All studies used animal models, except two human trials using a combined integrator. Narrative synthesis was performed via content analysis of demonstrated statistically significant effects and thematic analysis of proposed physiological mechanisms of intervention. Vitamin C/taurine demonstrated indirect effects on tendon healing through antioxidant activity. Vitamin A/glycine showed direct effects on extracellular matrix tissue synthesis. Vitamin E shows an antiproliferative influence on collagen deposition. Leucine directly influences signaling pathways to promote muscle protein synthesis. DISCUSSION:Preliminary evidence exists, demonstrating that vitamins and amino acids may facilitate multilevel changes in musculotendinous healing; however, recommendations on clinical utility should be made with caution. All animal studies and one human study showed high risk of bias with moderate interobserver agreement (k = 0.46). Currently, there is limited evidence to support the use of vitamins and amino acids for musculotendinous injury. Both high-quality animal experimentation of the proposed mechanisms confirming the physiological influence of supplementation and human studies evaluating effects on tissue morphology and biochemistry are required before practical application.
journal_name
Int J Sport Nutr Exerc Metabauthors
Tack C,Shorthouse F,Kass Ldoi
10.1123/ijsnem.2017-0267subject
Has Abstractpub_date
2018-05-01 00:00:00pages
294-311issue
3eissn
1526-484Xissn
1543-2742journal_volume
28pub_type
杂志文章,评审abstract::We previously reported that insulin resistance in skeletal muscle of obese individuals was associated with decreases in insulin signal transduction and tyrosine kinase activity of the insulin receptor. Herein is reviewed the recently published data supporting the hypothesis that protein kinase C (PKC) phosphorylates t...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,评审
doi:10.1123/ijsnem.11.s1.s64
更新日期:2001-12-01 00:00:00
abstract::Acute resistance exercise and L-arginine have both been shown to independently elevate plasma growth hormone (GH) concentrations; however, their combined effect is controversial. The purpose was to investigate the combined effects of resistance exercise and L-arginine supplementation on plasma L-arginine, GH, GH secre...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.2013-0106
更新日期:2014-04-01 00:00:00
abstract::This article describes the development, analysis, and implementation of the menu available to athletes and patrons in the main dining hall of the Athletes Village at the Sydney 2000 Olympic Games and the significant role of sports dietitians in this process. Menu design and development was informed by focus groups, li...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.19.4.340
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To illustrate the effects of low-carbohydrate (LC) and grain-based (GB) diets on body composition, biomarkers, athletic training, and performance in an elite triathlete. METHODS:The athlete followed 2 dietary interventions for 14 d while maintaining a prescheduled training program. Pre- and postintervention me...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.17.3.296
更新日期:2007-06-01 00:00:00
abstract::Combat sport athletes typically engage in a process called making weight, characterized by rapid weight loss (RWL) and subsequent rapid weight gain (RWG) in the days preceding competition. These practices differ across each sport, but no systematic comparison of the size of the changes in body mass exists. The aim was...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2018-0165
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To investigate the effects of polysaccharide from Gynostemma pentaphyllum on antioxidant activity in skeletal muscle of mice exercised to exhaustion. METHODS:Three polysaccharide fractions were obtained from G. pentaphyllum polysaccharide (GPP) and termed GPP1-a, GPP2-b, and GPP3-a. Gas chromatography (GC) and...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.22.6.479
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To compare the effects of a 3-week supplementation between two different mixtures of antioxidants and placebo on aerobic exercise performance in acute normobaric hypoxia. SUBJECTS/METHODS:Seventeen subjects were randomly assigned in a double-blind fashion to receive a broad-based antioxidants sup...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.2013-0118
更新日期:2014-04-01 00:00:00
abstract::Food intolerance is becoming increasingly prevalent, and increasing numbers of athletes have celiac disease. This poses challenges as dietary recommendations for exercise are largely based on gluten-containing carbohydrate-rich foods. The K4 cycle race covers 384 km around the Coromandel Peninsula, New Zealand. Lack o...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.22.4.304
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Time spent in sedentary activities (such as watching television) has previously been associated with several risk factors for cardiovascular disease (CVD) such as increased low-density lipoprotein cholesterol (LDL-C). Little is known about associations with lipoprotein subfractions. Using television and comp...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2013-0117
更新日期:2014-02-01 00:00:00
abstract::The effects of adaptation to a high-fat diet on endurance performance are equivocal, and there is little data regarding the effects on high-intensity exercise performance. This study examined the effects of a high-fat/moderate protein diet on submaximal, maximal, and supramaximal performance. Twenty non-highly trained...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1123/ijsnem.13.4.466
更新日期:2003-12-01 00:00:00
abstract::The aim of this study was to evaluate the food provision and nutrition support at the London 2012 Olympic (OG) and Paralympic Games (PG) from the perspective of sports nutrition experts attending the event. Participants (n = 15) were asked to complete an online survey and rate on a Likert scale menu qualities, food sa...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2013-0218
更新日期:2014-12-01 00:00:00
abstract::We investigated the effects of calcium supplementation and physical practice on the bone ultrasound properties and trabecular microarchitecture in children. 160 children aged 8-11 were randomly allocated to active or nonactive groups and to receive either a calcium-phosphate or a placebo powder for 6 months. Skeletal ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.16.6.580
更新日期:2006-12-01 00:00:00
abstract::This study systematically examined the influence of carbohydrate (sucrose), sodium, and caffeine on the fluid retention potential of beverages under euhydrated conditions, using the beverage hydration index method. Three cohorts, each of 12 young, healthy, active men, ingested 1 L of beverages containing four differen...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2018-0047
更新日期:2018-10-15 00:00:00
abstract::Little data exists on drinking behavior, sweat loss, and exercise intensity across a competitive handball tournament in elite female athletes. Heart rate (HR), fluid balance and sweat electrolyte content were assessed on 17 international players across a 6-day tournament involving 5 games and 2 training sessions playe...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2013-0210
更新日期:2015-02-01 00:00:00
abstract::Although beetroot juice, as a nitrate carrier, is a popular ergogenic supplement among athletes, nitrate is consumed through the regular diet as well. We aimed to assess the habitual dietary nitrate intake and identify the main contributing food sources in a large group of highly trained athletes. Dutch highly trained...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2016-0239
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:Increased core temperature (T(c)), impaired cardiovascular function, and dehydration contribute to fatigue during prolonged exercise in the heat. Although many studies have examined mechanisms addressing these factors, few have investigated the effect of cold beverage temperature on thermoregulation and exercis...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,评审
doi:10.1123/ijsnem.20.2.166
更新日期:2010-04-01 00:00:00
abstract::It is the position of Sports Dietitians Australia (SDA) that adolescent athletes have unique nutritional requirements as a consequence of undertaking daily training and competition in addition to the demands of growth and development. As such, SDA established an expert multidisciplinary panel to undertake an independe...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2014-0031
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Creatine supplementation (CS) has been reported to increase body mass and improve performance in high-intensity, short-duration exercise tasks. Research on CS, most of which has come into existence since 1994, has been the focus of several qualitative reviews, but only one meta-analysis, which was conducted ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,meta分析
doi:10.1123/ijsnem.13.2.198
更新日期:2003-06-01 00:00:00
abstract::The timing of carbohydrate ingestion and how this influences net muscle glycogen utilization and fatigue has only been investigated in prolonged cycling. Past findings may not translate to running because each exercise mode is distinct both in the metabolic response to carbohydrate ingestion and in the practicalities ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2019-0291
更新日期:2020-02-28 00:00:00
abstract::This study implemented a 2-week high carbohydrate (CHO) diet intended to maximize CHO oxidation rates and examined the iron-regulatory response to a 26-km race walking effort. Twenty international-level, male race walkers were assigned to either a novel high CHO diet (MAX = 10 g/kg body mass CHO daily) inclusive of gu...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2020-0224
更新日期:2021-12-31 00:00:00
abstract::The polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) affect vascular relaxation and involve factors (e.g., nitric oxide) that contribute to exercise-induced increases in skeletal-muscle blood flow (Q). The authors investigated whether DHA and EPA supplementation augments skeletal-...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.20.6.475
更新日期:2010-12-01 00:00:00
abstract::Agouti-related protein (AGRP) is an orexigenic peptide secreted from the arcuate nucleus (ARC) of the hypothalamus. AGRP increases food intake and plays a role in energy balance, adiposity, weight gain, and growth-hormone release. The objective of the current study was to examine the effects of running exercise on res...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.19.5.473
更新日期:2009-10-01 00:00:00
abstract::Eight healthy subjects, aged 39.0 ¿ 2.4 years, consumed four 6% carbohydrate-electrolyte solutions containing either one (glucose or fructose) or two transportable carbohydrates in single (glucose + fructose) or bound (sucrose) forms. Solution osmolalities ranged from 250 to 434 mOsm/kg H2O. The test solutions were in...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 临床试验,杂志文章
doi:10.1123/ijsnem.10.4.394
更新日期:2000-12-01 00:00:00
abstract::Athletes competing in individual sports such as judo are categorized by weight. Before competitions, weight cutting is common. This cross-sectional study was designed to characterize and determine the prevalence of rapid weight loss (RWL) among adolescent judo competitors. Male athletes aged 12- to 17-years old (N = 1...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2015-0196
更新日期:2016-06-01 00:00:00
abstract::Discrepancies in energy and macronutrient intakes between tests are apparent even when a solid prepackaged diet (Sdiet) is used to standardize dietary intake for preexperimental trials. It is unknown whether a liquid prepackaged diet (Ldiet) leads to improved adherence, resulting in lower variability in energy and mac...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.2018-0259
更新日期:2019-09-01 00:00:00
abstract::Research suggests that ingesting protein after resistance exercise (RE) increases muscle protein synthesis and results in greater muscle gains. The effect on energy expenditure and substrate utilization, however, is unclear. This study evaluated the effect of RE and postexercise protein on recovery energy expenditure ...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.17.6.544
更新日期:2007-12-01 00:00:00
abstract::This study aimed to assess the diet quality of Brazilian Paralympic track-and-field team sprinters and its variation between days. All sprinters (n = 28) were invited, and 20 (13 men and seven women) accepted the invitation consisting of 13 athletes with visual impairment, four with cerebral palsy, and three with limb...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2018-0361
更新日期:2019-06-05 00:00:00
abstract::Omega-3 fatty acid (n-3 FA) supplementation could promote adaptation to soccer-specific training. We examined the impact of a 4-week period of n-3 FA supplementation during training on adaptations in 1RM knee extensor strength, 20-m sprint speed, vertical jump power, and anaerobic endurance capacity (Yo-Yo test) in co...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1123/ijsnem.2016-0325
更新日期:2017-08-01 00:00:00
abstract::The Omega-3 Index is defined as erythrocyte eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and represents an individual's status in these two marine omega-3 fatty acids. A target range of 8 to 11% has been suggested, because values below predispose to cardiovascular events, especially sudden cardiac death...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 杂志文章
doi:10.1123/ijsnem.2014-0041
更新日期:2014-10-01 00:00:00
abstract::The purpose of this study was to measure the recovery kinetics of pH and lactate for the conditions of pre-exercise acidosis, alkalosis, and placebo states. Twelve trained male cyclists completed 3 exercise trials (110% workload at VO2max), ingesting either 0.3 g/kg of NH4Cl (ACD), 0.2 g/kg of Na+HCO3- and 0.2 g/kg of...
journal_title:International journal of sport nutrition and exercise metabolism
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1123/ijsnem.15.1.59
更新日期:2005-02-01 00:00:00