Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir.

Abstract:

:Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the JC virus; the mortality rate is high and it is usually refractory to treatment. In non-HIV patients, PML occurs as a late consequence of hematologic malignancies or during prolonged immunosuppression for transplantation or autoimmune disease. We describe a 34-year-old PML patient with incomplete Heerfordt syndrome, a rare type of sarcoidosis, who had not received any immunosuppressants, including steroids, at the onset and who was clinically and radiologically responsive to the antiviral drug cidofovir.

journal_name

Clin Neurol Neurosurg

authors

Yagi T,Hattori H,Ohira M,Nakamichi K,Takayama-Ito M,Saijo M,Shimizu T,Ito D,Takahashi K,Suzuki N

doi

10.1016/j.clineuro.2009.10.005

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

153-6

issue

2

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(09)00267-4

journal_volume

112

pub_type

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