Abstract:
UNLABELLED:Recent reports on the prevalence of multiple sclerosis (MS) have described discrepancies between the rates in cities in the northeastern and southeastern regions of Brazil, representing a north-south gradient. European immigrants settled in southeastern and southern Brazil at the beginning of the twentieth century. In this study, we report the frequency of European ancestors among Brazilian MS patients in four cities in the southern and southeastern regions of Brazil. METHODS:A total of 652 consecutive patients with confirmed MS diagnoses seen at four centers in Belo Horizonte, Ribeirão Preto, Londrina and Santos were asked about the origin of their ancestors, going back three generations. RESULTS:287 (44%) reported Italian ancestry, 211 (32%) reported that all ancestors were born in Brazil, 49 (7.5%) had Portuguese ancestry and 70 (10%) had Spanish ancestry. The patients in Belo Horizonte and Londrina reported higher proportions of Italian ancestry than the proportions estimated for the populations of their respective States. CONCLUSION:Brazil has a north-south gradient of 0.91/100,000 per degree of latitude, which is higher than the gradient for Latin America. Since the largest immigrant group that settled in southern and southeastern Brazil was from Italy, it is possible that Italian immigration was one of the factors that have contributed toward increasing the prevalence of MS in these regions.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Comini-Frota ER,Brum DG,Kaimen-Maciel DR,Fragoso YD,Barreira AA,Donadi EAdoi
10.1016/j.clineuro.2013.02.024subject
Has Abstractpub_date
2013-09-01 00:00:00pages
1642-6issue
9eissn
0303-8467issn
1872-6968pii
S0303-8467(13)00087-5journal_volume
115pub_type
杂志文章abstract::Intraoperative bilateral cavernous sinus sampling combined with rapid ACTH measurement was performed in a pilot study in seven patients with Cushing's disease during transsphenoidal pituitary surgery before and immediately after removal of the ACTH-producing pituitary microadenoma. Before tumor removal a gradient in A...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
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abstract::The validity and reproducibility of two simple coordination-tests, the spiraltest and nailtest were examined in 113 healthy subjects, 33 patients with Parkinson's disease and 24 patients suffering from cerebellar disorders. The performances of the healthy subjects decreased significantly with age but gender had no inf...
journal_title:Clinical neurology and neurosurgery
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doi:10.1016/0303-8467(90)90084-i
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abstract::Spinal meningiomas are uncommon entities that fortunately burden only a small minority of patients. Notwithstanding their overwhelmingly benign propensity, the occurrence of extramedullary meningioma may nonetheless cause significant morbidity and possible mortality. The consideration therefore, of spinal meningioma i...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/0303-8467(92)90069-f
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abstract::A case of Von Recklinghausen neurofibromatosis (VRNF) with progression during two pregnancies and obstetrical complications is described to illustrate the effect of pregnancy on VRNF and vice versa. The interaction between VRNF and pregnancy is discussed. The obstetrical complications and progression of VRNF lesions d...
journal_title:Clinical neurology and neurosurgery
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doi:10.1016/s0303-8467(87)80052-5
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
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journal_title:Clinical neurology and neurosurgery
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更新日期:1997-12-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
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doi:10.1016/j.clineuro.2007.09.012
更新日期:2008-02-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
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doi:10.1016/j.clineuro.2012.02.045
更新日期:2012-10-01 00:00:00
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doi:10.1016/j.clineuro.2007.10.013
更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.clineuro.2012.03.017
更新日期:2012-11-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2010.01.003
更新日期:2010-05-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/0303-8467(92)90040-a
更新日期:1992-01-01 00:00:00
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doi:10.1016/s0303-8467(75)80048-5
更新日期:1975-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.clineuro.2007.09.023
更新日期:2008-02-01 00:00:00
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doi:10.1016/j.clineuro.2013.04.008
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更新日期:2000-09-01 00:00:00
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doi:10.1016/j.clineuro.2014.08.010
更新日期:2014-11-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:Activation of the inflammatory cascade is a known pathophysiologic process in severe traumatic brain injury (TBI) with yet non-standardized scientific data regarding relationship to outcome. The understanding of the time course of expression of cerebrospinal fluid (CSF) biomarker levels following severe TBI i...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2016.06.009
更新日期:2016-10-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-12-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
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doi:10.1016/j.clineuro.2018.08.002
更新日期:2018-10-01 00:00:00
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更新日期:2014-12-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
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doi:10.1016/j.clineuro.2005.05.015
更新日期:2006-10-01 00:00:00
abstract::Nineteen homocystinuric patients--13 children and 6 adults--were identified in the course of a selective screening for homocystinuria due to cystathionine synthase deficiency. Treatment with high doses (300-1200 mg/day) of pyridoxine was carried out in 17 patients, of whom 15 were completely responsive. In 10 patients...
journal_title:Clinical neurology and neurosurgery
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doi:10.1016/0303-8467(83)90046-x
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:This study aims to investigate the genetic predisposition of haptoglobin (Hp) genotype as a predictor for cerebral vasospasm (CV) after acute subarachnoid hemorrhage (aSAH) in the Egyptian population. This permits CV risk factors stratification of patients with aSAH. Hence, it will guide the treatment plan an...
journal_title:Clinical neurology and neurosurgery
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doi:10.1016/j.clineuro.2020.106296
更新日期:2020-12-01 00:00:00