Abstract：
OBJECTIVE:Early brain injury after aneurysmal subarachnoid hemorrhage (aSAH) comprises a pronounced neuroinflammatory reaction. Nevertheless, its relevance for functional outcome and its role as outcome predictor remains uncertain. We evaluated the relationship of various early inflammatory parameters regarding functional outcome according to the modified Rankin Scale score (mRS) at discharge (primary objective) and six months after aSAH. PATIENTS:A total of 81 patients (63% female) with a mean age of 53.8 ± 13.2 years were included. METHODS:At admission clinical data and various inflammatory parameters in serum and - wherever applicable - cerebrospinal fluid (CSF) of patients after aSAH were assessed. Outcome was evaluated according to dichotomized mRS at discharge and six months after aSAH (unfavorable outcome: mRS 3-6). Univariate and thereafter multivariate logistic regression analyses were performed using SAS 9.2. RESULTS:Elevated levels of interleukin 6 (IL-6) and leukemia inhibitory factor (LIF) in serum and CSF were related to unfavorable outcome at discharge (p<0.05; univariate analyses). IL-6 remains the only parameter relevant for outcome applying a multivariate model including the relevant baseline characteristics. Six months after aSAH no significant correlation was found regarding the outcome, most likely due to the high drop-out rate (27%). A pronounced rise of LIF serum and CSF levels after aSAH was observed. CONCLUSION:Higher early IL-6 serum levels after aSAH are associated with poor outcome at discharge. In addition, involvement of LIF in the early inflammatory reaction after aSAH has been demonstrated.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Höllig A,Remmel D,Stoffel-Wagner B,Schubert GA,Coburn M,Clusmann Hdoi
10.1016/j.clineuro.2015.08.030subject
Has Abstractpub_date
2015-11-01 00:00:00pages
177-83eissn
0303-8467issn
1872-6968pii
S0303-8467(15)00312-1journal_volume
138pub_type
杂志文章abstract：OBJECTIVES:There is clinical and experimental evidence involving the insula in the control of the autonomic system and cardiac function, with differential participation of right and left brain hemispheres, and these differences could influence mortality in the acute phase of brain hemisphere ischemic infarcts. METHODS...
journal_title：Clinical neurology and neurosurgery
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journal_title：Clinical neurology and neurosurgery
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更新日期：2007-09-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
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journal_title：Clinical neurology and neurosurgery
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journal_title：Clinical neurology and neurosurgery
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journal_title：Clinical neurology and neurosurgery
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更新日期：2017-12-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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doi：10.1016/j.clineuro.2018.07.020
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pub_type： 杂志文章
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
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更新日期：2016-11-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
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pub_type： 杂志文章
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