Familial spastic paraplegia: evidence for a fourth locus.

Abstract:

:Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetically heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) to chromosome 15q. We now report a large Dutch family with AD-FSP without linkage to any of these chromosomes, providing evidence for a fourth locus (FSP4).

journal_name

Clin Neurol Neurosurg

authors

Bruyn RP,van Veen MM,Kremer H,Scheltens PH,Padberg GW

doi

10.1016/s0303-8467(97)00602-1

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

87-90

issue

2

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(97)80002-9

journal_volume

99

pub_type

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