Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung.

Abstract:

:Paraneoplastic cerebellar degeneration (PCD) is the most frequent paraneoplastic syndrome affecting the brain. Until now, anti-Tr associated PCD was only seen in patients with Hodgkin's disease. We report a male patient who presented with a progressive ataxia, affecting predominantly the lower limbs and a cerebellar dysarthria. Extensive diagnostic approach initially showed no evidence of tumor. The patient was found to have anti-Tr antibodies in his serum. Fourteen months after onset of symptoms a whole body PET-scan showed a pathological focus at the right hilus of the lungs. A mediastinoscopy was performed and peribronchial node sampling was done. The anatomopathological analysis revealed a non-well differentiated squamous cell carcinoma. This is the first report about the association between an anti-Tr associated PCD and squamous cell carcinoma.

journal_name

Clin Neurol Neurosurg

authors

Bruylant K,Crols R,Humbel RL,Appel B,De Deyn PP

doi

10.1016/j.clineuro.2005.01.008

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

415-7

issue

4

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(05)00019-3

journal_volume

108

pub_type

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