Chronic post-stroke fatigue: It may no longer be about the stroke itself.


OBJECTIVE:Post-stroke fatigue (PSF) is a debilitating complication of stroke recovery. Contributing risk factors, whether they are modifiable, and if they change over time remain understudied. We determine factors associated with PSF and how they evolve from the subacute through chronic phases of recovery. PATIENTS AND METHODS:A consecutive series of patients presenting to our comprehensive stroke center with acute stroke were seen in follow-up within 6 months of infarct and administered the Functional Assessment of Chronic Illness Therapy (FACIT) fatigue scale to evaluate for PSF. It was re-administered >6 months post-infarct. Demographics, stroke characteristics (NIH Stroke Scale [NIHSS], infarct size and location), medical comorbidities, and outcomes (modified Rankin Scale [mRS]) were also recorded. Regression analyses were used to determine factors associated with FACIT scores and PSF at each time point. RESULTS:203 patients were administered the FACIT a mean 1.6 months post-stroke; 128 underwent re-administration (mean 13.9 months post-event). In adjusted models, stroke severity (follow-up NIHSS [p < 0.001], mRS [p = 0.005]) and posterior circulation localization (p = 0.012) were associated with lower FACIT scores (increased fatigue) in the subacute setting, while medical comorbidities (hypertension [p = 0.024], obstructive sleep apnea [p = 0.020]) and medication use (anticonvulsants [p = 0.021]) were associated with lower scores chronically. Baseline depression (p < 0.001, p = 0.029) was associated with lower scores at both time points. CONCLUSION:Early PSF appears to be largely attributable to stroke severity, while chronic fatigue occurs in the setting of medical comorbidities and medication use. This has significant clinical implications when considering management strategies at different stages of recovery.


Clin Neurol Neurosurg


Chen K,Marsh EB




Has Abstract


2018-11-01 00:00:00












  • Radiotherapy in brain-stem gliomas in children.

    abstract::Twenty-one children with brain-stem glioma are discussed. Sixteen received radiotherapy and five were too sick to be irradiated. The mean survival was 3.4 weeks for the non-irradiated group and 8.7 months for the treated group, two of the latter being still alive five and ten months after diagnosis. From the literatur...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Ataç MS,Blaauw G

    更新日期:1979-01-01 00:00:00

  • Difference of the hippocampal and white matter microalterations in MCI patients according to the severity of subcortical vascular changes: neuropsychological correlates of diffusion tensor imaging.

    abstract:OBJECTIVES:Most imaging studies of mild cognitive impairment (MCI) have focused on gray matter alterations, although many MCI patients demonstrate subcortical vascular changes. We investigated the changes of the hippocampal area and various white matter areas in MCI patients with using diffusion tensor imaging (DTI), a...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Shim YS,Yoon B,Shon YM,Ahn KJ,Yang DW

    更新日期:2008-06-01 00:00:00

  • Cluster headache patients are not affected by restless legs syndrome: an observational study.

    abstract:OBJECTIVE:To investigate the presence of Restless Legs Syndrome (RLS) in Cluster Headache (CH) patients compared to headache-free controls. DESIGN AND SETTING:Cross-sectional case-control study of CH patients presenting at tertiary headache centers over the period January-December 2008. PATIENTS AND PARTICIPANTS:Fift...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Florindo D,Daniela C,Giulio C,Vittorio P,Gabriella M,Vincenzo T,Eliana M,Gerardo C,Gennaro B

    更新日期:2011-05-01 00:00:00

  • Molecular and clinical prognostic factors for favorable outcome following surgical resection of adult intramedullary spinal cord astrocytomas.

    abstract:OBJECTIVE:Intramedullary spinal cord astrocytomas are uncommon but important entities. Aggressive surgical resection is believed to be critical to prevent subsequent neurological deterioration; however, the prognostic significance of numerous patient and molecular variables remains unclear. We sought to investigate the...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Xiao R,Abdullah KG,Miller JA,Lubelski D,Steinmetz MP,Shin JH,Krishnaney AA,Mroz TE,Benzel EC

    更新日期:2016-05-01 00:00:00

  • Intraspinal juxta-facet cysts: a case of bilateral ganglion cysts.

    abstract::Juxta-facet cysts are relatively uncommon intraspinal lesions, causing radiculopathy, neurogenic claudication or myelopathy. To the best of our knowledge, only 4 cases of bilateral synovial or ganglioncysts were described. We report the 5th case of bilateral ganglioncysts of the lumbar spine. Generally, juxta-facet cy...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


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    更新日期:1992-01-01 00:00:00

  • One-stage coiling versus clipping of multiple intracranial aneurysms in elderly patients.

    abstract:OBJECTIVES:Although multiple intracranial aneurysms (MIAs) are frequent and disastrous, determining treatment strategy for them is often complicated, especially in elderly patients (≥60 years old). We evaluated the safety and effectiveness of one-stage coiling versus surgical clipping for MIAs in elderly patients. MET...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Xie Q,Gu Y,Song Y,Leng B,Zheng Y,Xu F

    更新日期:2020-12-05 00:00:00

  • Long-time microdialysis in a patient with meningoencephalitis.

    abstract::As part of invasive neuromonitoring, long-time microdialysis was performed in a 32-year-old patient suffering from meningoencephalitis. Cerebral magnetic resonance imaging (MRI) revealed marked global brain oedema. An intracranial pressure (ICP) probe, brain tissue oxygen pressure measurement (pTiO(2)), and intraparen...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Gliemroth J,Bahlmann L,Klaus S,Klöhn A,Arnold H

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  • Can a rare form of myasthenia gravis shed additional light on disease mechanisms?

    abstract::A healthy 43-year-old physician developed gradually progressive and fluctuating fatigable muscle weakness involving ocular, limb, bulbar and respiratory muscles, with episodic acute respiratory failure, eventually necessitating intermittent non-invasive respiratory support (NIV). A mild short episode occurred 15 years...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Haran M,Schattner A,Mate A,Starobin D,Haran G,Shtalrid M

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    abstract::Coincidence of pulmonal sarcoidosis and progressive multifocal leukoencephalopathy (PML) rarely occurs. So far an entire course has been recorded in only very few cases. We demonstrate the case of a 49-year-old male developing an infratentorial localized PML in the setting of advanced pulmonal sarcoidosis. PML was not...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Völker HU,Kraft K,Arnold E,Steinhoff S,Kolios G,Sommer S

    更新日期:2007-09-01 00:00:00

  • The interleukin-10 levels as a potential indicator of positive response to interferon beta treatment of multiple sclerosis patients.

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Bartosik-Psujek H,Stelmasiak Z

    更新日期:2006-10-01 00:00:00

  • Optic nerve MRI enhancement in posterior ischaemic optic neuropathy due to internal carotid artery dissection.

    abstract::Posterior ischaemic neuropathy (PION) is characterized by infarction in the retrobulbar optic nerve. A 73-year-old man suddenly experienced blurred vision in his left eye and intermittent weakness in his right hand. He had visual defects of superior lateral quarter and inferior medial quarter areas in the left eye. Ga...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Kawabe K,Nagaoka T,Iguchi H,Ikeda K,Iwasaki Y

    更新日期:2010-05-01 00:00:00

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    abstract::While intervention for ruptured arteriovenous malformations (AVMs) of the brain is typically warranted, the management of unruptured AVMs remains controversial. Despite numerous retrospective studies, only one randomized controlled trial has been conducted, comparing the role of medical management alone to medical man...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章,评审


    authors: Hong CS,Peterson EC,Ding D,Sur S,Hasan D,Dumont AS,Chalouhi N,Jabbour P,Starke RM

    更新日期:2016-11-01 00:00:00

  • Pitfalls, fallacies and false positive rates.

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: van Dijk JG

    更新日期:1992-01-01 00:00:00

  • Demographic, radiographic, molecular and clinical characteristics of primary gliosarcoma and differences to glioblastoma.

    abstract:OBJECTIVE:Gliosarcoma (GSC) is a rare histological variant of glioblastoma (GBM). Due to limited evidence regarding clinical, genetic and radiographic characteristics of GSC, this study aimed to analyze independent outcome predictors of GSC, and to address the differences between GSC and GBM concerning the baseline cha...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Pierscianek D,Ahmadipour Y,Michel A,Rauschenbach L,Darkwah Oppong M,Deuschl C,Kebir S,Wrede KH,Glas M,Stuschke M,Sure U,Jabbarli R

    更新日期:2021-01-01 00:00:00

  • Endermology: a treatment for injection-induced lipoatrophy in multiple sclerosis patients treated with sub cutaneous glatiramer acetate.

    abstract:OBJECTIVE:To evaluate sessions of endermology (LPG) on patients with lipoatrophy, due to GA injections in an open-labelled study. BACKGROUND:Glatiramer acetate (GA) is an immunomodulatory drug, with an excellent safety profile, that is currently used for treatment of multiple sclerosis and is administered as daily sub...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Lebrun C,Mondot L,Bertagna M,Calleja A,Cohen M

    更新日期:2011-11-01 00:00:00

  • Influencing factors of hemorrhagic transformation in non-thrombolysis patients with cerebral infarction.

    abstract:OBJECTIVES:Hemorrhagic transformation (HT) is a serious complication of acute cerebral infarction. The aim of study is to investigate the influencing factors of HT in non-thrombolysis patients with acute cerebral infarction, and to explore its clinical significance. PATIENTS AND METHODS:From June 2016 to March 2017, a...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Jiao Y,Li G,Xing Y,Nie D,Liu X

    更新日期:2019-06-01 00:00:00

  • Spinal intramedullary tuberculosis: a series of 15 cases.

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Ramdurg SR,Gupta DK,Suri A,Sharma BS,Mahapatra AK

    更新日期:2009-02-01 00:00:00

  • Transradial access for thrombectomy in acute stroke: A systematic review and meta-analysis.

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Peterson C,Waldau B

    更新日期:2020-11-01 00:00:00

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Bruyn GW,Klawans HL

    更新日期:1975-01-01 00:00:00

  • Angiographic features, surgical management and outcomes of proximal middle cerebral artery aneurysms.

    abstract:OBJECTIVE:Understanding the microanatomy of the proximal middle cerebral artery (M1) and its early branches is very important for aneurysm surgery in this region. However, few articles provide detailed descriptions of such aneurysms. We report the angiographic characteristics of a series of M1 aneurysms and our experie...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Park DH,Kang SH,Lee JB,Lim DJ,Kwon TH,Chung YG,Lee HK

    更新日期:2008-06-01 00:00:00

  • The impact of deep brain stimulation on health related quality of life and disease-specific disability in Meige Syndrome (MS).

    abstract::Meige Syndrome (MS) is a disabling movement disorder which impairs daily routines such as eating and speaking and, when not responsive to best medical treatment, deep brain stimulation (DBS) of the globus pallidus interna (GPi) has been considered. Previous evidence has shown a significant improvement in motor dysfunc...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章,评审


    authors: Aires A,Gomes T,Linhares P,Cunha F,Rosas MJ,Vaz R

    更新日期:2018-08-01 00:00:00

  • Persistent posterior fossa ependymomas. Two case reports with unusual long survival.

    abstract::Two patients are described who survived respectively 33 and 21 years after partial surgical excision of a posterior fossa ependymoma and who at the time of autopsy were proven to harbor persistent tumour tissue in the same location. ...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Slooff JL

    更新日期:1975-01-01 00:00:00

  • Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy.

    abstract::Pure red cell aplasia (PRCA) is well known to be concomitant with myasthenia gravis (MG), but it is difficult to predict the development of PRCA in patients with MG. Of 135 patients with MG, four (2.9%) had PRCA. All patients developed PRCA after thymectomy during a period when MG was in remission. The frequencies of ...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Suzuki S,Nogawa S,Tanaka K,Koto A,Fukuuchi Y,Kuwana M

    更新日期:2003-12-01 00:00:00

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Neyazi B,Siblini A,Frantsev R,Özkan N,Sandalcioglu IE,Sure U,Maslehaty H

    更新日期:2020-02-01 00:00:00

  • Abducens palsy after lumbar puncture.

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Niedermüller U,Trinka E,Bauer G

    更新日期:2002-01-01 00:00:00

  • Occipitocervical fusion: fix to C2 or C3?

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Pan J,Huang D,Hao D,Zhao Y,He B,Wu Q,Li H,Ge C

    更新日期:2014-12-01 00:00:00

  • Successful treatment for giant pituitary adenomas through diverse transcranial approaches in a series of 15 consecutive patients.

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Guo F,Song L,Bai J,Zhao P,Sun H,Liu X,Yang B,Wang S

    更新日期:2012-09-01 00:00:00

  • Clinical characteristics of headache or facial pain prior to the development of acute herpes zoster of the head.

    abstract:OBJECTIVES:When physicians encounter patients with headache or facial pain (preeruptive pain) associated with acute herpes zoster of the head, especially before the appearance of characteristic skin eruptions (preeruptive phase), they typically find it difficult to make clinical impressions and apply appropriate diagno...

    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Lee HL,Yeo M,Choi GH,Lee JY,Kim JS,Shin DI,Lee SS,Lee SH

    更新日期:2017-01-01 00:00:00

  • Sellar abnormalities in female first-degree relatives.

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Gabeau-Lacet D,Grant E,Stemmer-Rachamimov A,Yock T,Tarbell NJ

    更新日期:2008-02-01 00:00:00

  • A follow-up study on outcomes of endoscopic transsphenoidal approach for acromegaly.

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    journal_title:Clinical neurology and neurosurgery

    pub_type: 杂志文章


    authors: Aydin S,Ozoner B,Sahin S,Alizada O,Comunoglu N,Oz B,Gazioglu N,Kadioglu P,Tanriover N

    更新日期:2020-11-01 00:00:00